Recombinant Mouse Cerebellin-1 (Cbln1)

1. Results show that Cbln1, Cbln2, and Cbln4 are abundantly expressed in nearly all brain regions, but exhibit strikingly different expression patterns and developmental dynamics. Using newly generated knockin reporter mice for Cbln2 and Cbln4, we find that Cbln2 and Cbln4 are not universally expressed in all neurons, but only in specific subsets of neurons. PMID: 28714144
2. results suggest that gene and seizure interactions in ventral tegmental area glutamatergic neurons impair sociability by downregulating Cbln1, a key node in the expanding protein interaction network of autism genes PMID: 28297715
3. Despites its well known role in motor coordination and motor learning, whether and how the cerebellum is involved in cognitive functions remains less clear. Cerebellin 1 (Cbln1) is highly expressed in the cerebellum and serves as an essential synaptic organizer. Although genes encoding Cbln1 and its receptor are associated with many psychiatric disorders, it remains unknown whether such cognitive impairments are caused by PMID: 27852787
4. amplitude and frequency of mIPSCs were increased in cbln1-null cerebellar slices. PMID: 24467251
5. This study provides evidence for involvement of Cbln1 in nociception and provides a platform for continued exploration of involvement of novel neuropeptides in the regulation of nociceptive transmission PMID: 24749662
6. that neurons expressing Cblns 1, 2, and 4 tend to occupy different laminar positions within the dorsal spinal cord PMID: 23853053
7. extracerebellar structures or remaining PF-PC synapses in cbln1(-/-) mice may be sufficient for the expression, maintenance, and extinction of its memory trace. PMID: 24298240
8. Cbln1 released from parallel fiber Purkinje cells induces dynamic structural changes in parallel fibers. PMID: 23141067
9. [review] The Cbln1-GluRdelta2 receptor complex is located at the cleft of parallel fiber-Purkinje cell synapses and bidirectionally regulates both presynaptic and postsynaptic differentiation. PMID: 20535596
10. GluRdelta1 stimulated inhibitory synapse formation in the presence of Cbln1 or Cbln2 PMID: 22191730
11. Data show that Cbln1 and Cbln2, but not Cbln4, specifically bind to neurexin 1alpha and -beta and induce synaptogenesis in cerebellar, hippocampal and cortical neurons in vitro. PMID: 21410790
12. These results suggest that Cbln1 and Cbln2 play a role in synapse formation of cortical neurons by interacting with NRXNs containing S4. PMID: 21356198
13. Otolin 1 interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1 in the inner ear. PMID: 20856818
14. Our observation that loss of Cbln1 leads to increased numbers of striatal medium spiny neurons' dendritic spines suggests that modulating thalamostriatal Cbln1 may be a novel means of improving symptoms or slowing progression in Parkinson's disease. PMID: 20503425
15. the flap loop (Arg321-Trp339) in the NTD of GluD2 (GluD2-NTD) was identified as a crucial region for the binding to Cbln1 and the induction of presynaptic differentiation. PMID: 20599760
16. Results suggest that GluRdelta2 mediates cerebellar synapse formation by interacting with presynaptic NRXNs through Cbln1. PMID: 20537373
17. study found that Cbln1 binds directly to the N-terminal domain of glutamate receptor delta2 (GluD2); results indicate that the Cbln1-GluD2 complex is a unique synapse organizer that acts bidirectionally on both pre- and postsynaptic components PMID: 20395510
18. the cleavages required to produce cerebellin influence the subunit stoichiometry of Cbln1 complexes PMID: 16135095
19. In the developing brain, Cbln1 mRNA appeared as early as embryonic day 10-13, and exhibited transient up-regulation during the late embryonic and neonatal periods. PMID: 16930405
20. Cbln1 is required for endoplasmic reticulum export and secretion of Cbln3. PMID: 17030622
21. During development of cbln1-lacZ mice, beta-galactosidase staining was first observed in proliferating granule cell precursors prior to synaptogenesis and thereafter in maturing and adult granule cells. PMID: 18001291
22. Cbln1 is a unique synapse organizer that is required not only for the normal development of parallel fiber-Purkinje cell synapses but also for their maintenance in the mature cerebellum both in vitro and in vivo. PMID: 18524896
23. These results indicate that Cbln1, released from granule cells as hexamers, specifically binds to a putative receptor located at the postsynaptic sites of parallel-Purkinje cell synapses. PMID: 19200061
24. immunohistochemical localization suggests the basis for anatomical convergence of the Cbln-GluRdelta2 signaling pathway in parallel fiber-Purkinje cell synapses PMID: 19250438
25. Data show that Cbln1 undergoes anterograde transport from granule cells to Purkinje cells and Bergmann glia and enters the endolysosomal trafficking system, suggesting that Cbln1 exerts its activity on or within Purkinje cells and Bergmann glia. PMID: 19344768
26. Activity-dependent downregulation of Cbln1 may serve as a new presynaptic mechanism by which parallel fibers-Purkinje cell synapses adapt to chronically elevated activity, thereby maintaining homeostasis. PMID: 19403810

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KEGG: mmu:12404

STRING: 10090.ENSMUSP00000034076

UniGene: Mm.4880