Recombinant Mouse Estrogen-related receptor gamma (Esrrg)

1. Estrogen-related receptor gamma (ERRgamma) overexpression in chondrocytes directly upregulates matrix metalloproteinase (MMP)-3 and MMP13, which are known to play crucial roles in cartilage destruction in osteoarthritis (OA). PMID: 29247173
2. MiR-204-5p inhibits myoblast differentiation by targeting MEF2C and ERRgamma. PMID: 29505923
3. Loss of ERRgamma in renal epithelial cells Results in Kidney Disease with Cysts. PMID: 29735694
4. Muscle ERRgamma over-expression successfully triggered glycolytic-to-oxidative myofiber switch, increased functional mitochondrial content and boosted vascular supply in the db/db mice. PMID: 27220353
5. The research findings suggest that estrogen-related receptor gamma (ERRgamma) regulates testicular steroidogenesis, both directly controlling and indirectly fine-tuning the expression of steroidogenic genes. PMID: 28479375
6. These findings strongly support a role for ERRgamma in the metabolic alterations that underlie the development of diabetic cardiomyopathy. PMID: 27062900
7. our results reveal that ERRgamma, induced via activation of the hepatic CB1 receptor, is a regulator of hepatic FGF21 gene expression and secretion. PMID: 27455076
8. Study conclude that O-GlcNAcylation of ERRgamma serves as a major signal to promote hepatic gluconeogenesis. PMID: 27335230
9. Mice deficient in beta cell-specific ERRgamma expression are glucose intolerant and fail to secrete insulin in response to a glucose challenge. PMID: 27076077
10. mediates metabolic transition, which is required for induced pluripotency PMID: 25865501
11. ERRgamma plays a key role in vascular calcification by upregulating the BMP2 signaling pathway. PMID: 26404484
12. Mice lacking neuronal ERRgamma in cerebral cortex and hippocampus exhibit defects in spatial learning and memory. PMID: 25863252
13. These results suggest that ERRgamma is a major contributor to insulin action in maintaining hepatic glucose homeostasis. PMID: 25205222
14. ERRgamma is a sexdependent and RUNX2-dependent negative regulator of osteoblast differentiation, and that its regulatory activity may also be differentiation stage-dependent. PMID: 25313644
15. Orphan nuclear receptor Errgamma induces C-reactive protein gene expression through induction of ER-bound Bzip transmembrane transcription factor CREBH. PMID: 24466039
16. Cartilage-specific overexpression of ERRgamma results in chondrodysplasia and reduced chondrocyte proliferation. PMID: 24349082
17. These findings demonstrate a novel ERRgamma/GATA4 signal cascade in the development of cardiac hypertrophy. PMID: 24083978
18. Esrrg modulates the intramacrophage proliferation of S. typhimurium by altering host iron homeostasis. PMID: 24658075
19. ERRgamma was preferentially expressed in brown compared to white fat depots, and ERRgamma was induced during cold-induced browning of subcutaneous white adipose tissue and brown adipogenesis PMID: 23404793
20. This study showed that the ERRgamma-dependent metabolic and angiogenic gene program is defective in Duchenne muscular dystrophy, and its restoration is a potential strategy for treating muscular dystrophy. PMID: 23781095
21. plays a role in maintenance of hearing in both humans and mice. PMID: 23540940
22. Estrogen-related receptor gamma controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol. PMID: 23023167
23. Type I muscle fiber proportion is increased via the stimulatory actions of ERRG on the expression of miR-499 and miR-208b. PMID: 23676496
24. results suggest that loss of ERRgamma causes metabolic defects and oxidative stress that impair myotube formation through activation of skeletal muscle atrophy pathways PMID: 23038752
25. Orphan nuclear receptor estrogen-related receptor gamma (ERRgamma) is key regulator of hepatic gluconeogenesis PMID: 22549789
26. Esrrg is a novel lupus susceptibility gene that regulates the function and activation of CD4+ T cells through their mitochondrial metabolism. PMID: 22711888
27. ERRgamma is a hypoxia-independent inducer of neoangiogenesis that can promote reparative revascularization in ischemic skeletal muscle. PMID: 22415017
28. Estrogen-related receptor gamma (ERRgamma) is a novel transcriptional regulator of phosphatidic acid phosphatase, LIPIN1, and inhibits hepatic insulin signaling PMID: 21911493
29. ERR gamma genetically activates the energy sensor AMPK in mediating the metabovascular changes in ERRGO mice. PMID: 21356518
30. Esrrg is required for early branching events of the ureteric duct that occur prior to the onset of nephrogenesis. PMID: 21138943
31. ERRgamma plays an important role in causing a shift toward slow twitch muscle type and, concomitantly, a greater capacity for endurance exercise. PMID: 20418374
32. Renal, gastric, and cardiac tissues subjected to genomic expression analysis in perinatal ERRgamma null mice reveal dysregulation of genes involved in ion transport processes. PMID: 19965931
33. Transcriptional activation by ERR3 can be ligand-independent. PMID: 11864604
34. Domains of ERRgamma that mediate homodimerization and interaction with factors stimulating DNA binding were characterized. PMID: 12180985
35. results provide detailed molecular insight into the conformational changes occurring upon binding of synthetic antagonists to the constitutive orphan receptor estrogen-related receptor (ERR) gamma PMID: 15161930
36. work reveals a novel mechanism that negatively regulates the transcriptional function of ERRgamma by GNL3L through coactivator competition PMID: 17623774
37. The results suggest that ERRgamma positively regulate the adipocyte differentiation with modulating the expression of various adipogenesis-related genes. PMID: 18809516
38. ERRgamma is a novel negative regulator of osteoblast differentiation and bone formation via its regulation of Runx2 transactivity. PMID: 19324883
39. Err3 is expressed at high levels in gamma but not alpha motor neurons, whereas the neuronal DNA binding protein NeuN marks alpha but not gamma motor neurons. PMID: 19651609

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KEGG: mmu:26381

STRING: 10090.ENSMUSP00000027906

UniGene: Mm.388156