Recombinant Mouse Fermitin family homolog 3 (Fermt3)

1. expression is markedly suppressed in pathologically activated osteoclasts PMID: 29141864
2. Structure and lipid-binding properties of the kindlin-3 pleckstrin homology domain has been reported. PMID: 27974389
3. Mice expressing as little as 5% of kindlin-3 were viable and protected from spontaneous bleeding and infections. In vitro platelet functions, leukocyte adhesion, extravasation, and bacterial clearance were diminished. Bleeding time increased. PMID: 26438512
4. The accumulation of HSPCs in the circulation of leukocyte adhesion deficiency type III patients, who lack Kindlin-3, underlines the conserved functions of Kindlin-3 in man and the importance of our findings for human disease. PMID: 26282877
5. Optimal T cell activation and B cell antibody responses in vivo require the interaction between Integrin beta2 and kindlin-3. PMID: 25987740
6. Direct binding of kindlin-3 to integrin alphaIIbbeta3 is involved in supporting integrin alphaIIbbeta3 activation and integrin alphaIIbbeta3-dependent responses of platelets and consequently contributes significantly to arterial thrombus formation. PMID: 24969775
7. ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding. PMID: 24523237
8. the requirement of Kindlin-3 for effector T cells to induce alpha4beta1 and alphaLbeta2 integrin ligand binding and stabilization of integrin-ligand bonds is critical when integrin ligand levels are low, but of less importance when integrin ligand levels are high. PMID: 24089451
9. This is the first in vivo demonstration that Kindlin-3-stabilized integrin adhesions, although essential for lymphocyte arrest on blood vessels and interstitial motility, are not obligatory for leukocyte diapedesis. PMID: 23980064
10. the beta-2-integrin-kindlin-3 interaction is particularly important in adhesion strengthening under shear flow, and for T-cell homing to lymph nodes, but dispensable for T cell activation which occurs in a shear-free environment PMID: 23823319
11. Kindlin-3 is central to conversion of mechanical force to intracellular signaling via calcium influx. PMID: 23144497
12. Data indicate that Kindlin-3 specifically recognizes the integrin membrane-distal tail NPXY motif in both the beta(1A) and beta(1D) isoforms. PMID: 22989875
13. Both talin-1 and kindlin-3 are required for induction of the high-affinity conformation of LFA-1 with an open headpiece, which results in neutrophil arrest. PMID: 22431571
14. We investigated the role of talin-1, kindlin-3, and alpha-actinin-1 in the upregulation of alpha(4)beta(1) integrin affinity and consequent inflammatory leukocyte adhesive events PMID: 21911599
15. Osteoclasts require their entire integrin repertoire to be regulated by kindlin-3 to orchestrate bone homeostasis. PMID: 21357746
16. The genomic organization, gene expression and subcellular localization of murine Kindlins-1 to -3, is described. PMID: 16876785
17. Kindlin-3 was identified as a novel and essential element for platelet integrin activation in hemostasis and thrombosis. PMID: 18278053
18. Stable isotope labeling by amino acids in cell culture confirmed their absence and disclosed a structural defect of the red blood cell membrane skeleton in Kindlin-3-deficient erythrocytes. PMID: 18662549
19. identify a genetic disease that severely compromises the health of the affected individuals and establish an essential role of KINDLIN-3 in integrin activation in humans PMID: 19234460
20. Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects PMID: 19240021

Show More

Hide All

KEGG: mmu:108101

STRING: 10090.ENSMUSP00000037858

UniGene: Mm.157591