Recombinant Mouse Forkhead box protein E1 (Foxe1)

Code CSB-YP844440MO
MSDS
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Source Yeast
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Code CSB-EP844440MO
MSDS
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Source E.coli
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Code CSB-EP844440MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP844440MO
MSDS
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Source Baculovirus
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Code CSB-MP844440MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Foxe1
Uniprot No.
Alternative Names
Foxe1; Titf2Forkhead box protein E1; Thyroid transcription factor 2; TTF-2
Species
Mus musculus (Mouse)
Expression Region
1-371
Target Protein Sequence
MTAESAPPPP PQPETLAAVK EERGEAAAAG AGVPAEAAGR GAGGRRRKRP LQRGKPPYSY IALIAMAIAH APERRLTLGG IYKFITERFP FYRDNPKKWQ NSIRHNLTLN DCFLKIPREA GRPGKGNYWA LDPNAEDMFE SGSFLRRRKR FKRSDLSTYP AYMHDAAAAA AAAAAAIFPG AVPAARPAYP GAVYAGYAPP LAAPPPVYYP AASPGPCRVF GLVPERPLSP DLGPAPSAAG GSCAFAAAAG AAGTGSFQPA VCTGARPVNP AAYAAAYAGP DGAYPQGASS ALFAAAAGRL AGPASPPAGG GSGGVEATVD FYGRTSPGQF GAALGPCYNP GGQLGAGGGG AYHSRHATAY PGAVDRFVSA M
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression.
Gene References into Functions
  1. These results indicate that Foxe1 overexpression is not directly involved in the development of thyroid cancer and that proper Foxe1 dosage is essential for achieving normal structure and function of the thyroid. PMID: 26982637
  2. Foxe1 mRNA expression was suppressed in HR-overexpressing skin, as well as in HR-expressing keratinocytes. PMID: 21777520
  3. MSX1 and TGF-beta3 are direct targets of FOXE1. PMID: 21177256
  4. Data report a detailed expression pattern of thyroid transcription factor-2 protein during mouse embryogenesis. PMID: 12203737
  5. Foxe1 is required for hair follicle morphogenesis. PMID: 15367491

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Subcellular Location
Nucleus.
Tissue Specificity
Expressed in Rathke pouch, in thyroid, and in the epithelium of the pharyngeal wall and arches, whereas it is absent in the epithelium of the pharyngeal pouches.
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