Recombinant Mouse Forkhead box protein P2 (Foxp2)

1. findings also indicate that Foxp2 helps to regulate strength and length of hind limbs and maintenance of joint cartilage and intervertebral discs, which are all anatomical features that are susceptible to adaptations for bipedal locomotion. PMID: 30104377
2. Foxp2 has a putative HuR binding sites in the 3' UTR. Phosphorylation sites on HuR act in post-transcriptional regulation of Foxp2. PMID: 27383233
3. The expression levels of Foxp2 were high in the posterior region and low in the anterior region of the thalamic primordium. PMID: 27384060
4. Here, the authors show that the telencephalic preoptic area is comprised of distinct progenitor pools complementarily marked by the transcription factors Dbx1 and Foxp2. As determined by molecular and electrophysiological criteria this embryonic parcellation predicts postnatal medial subnucleus of the amygdala inhibitory neuronal subtype identity. PMID: 28244870
5. Eesults indicate a role of FoxP2 differential expression in cell morphology control of the vertebrate telencephalon. PMID: 26163006
6. that Foxp2-Mef2C signaling is critical to corticostriatal circuit formation PMID: 27595386
7. Sumoylation of forkhead box P2 in neonatal mouse cerebellum regulates Purkinje cell development and motor functions and vocal communication, demonstrating evidence for sumoylation in regulating mammalian behaviors. PMID: 27009683
8. The Foxp2 gene is critical for normal vocal behavior in juvenile and adult mice. PMID: 26980647
9. This study demonstrated that after middle cerebral artery occlusion mice demonstrate profoundly impaired socially evoked USVs and suppression of the language-associated transcription factor, Forkhead box protein 2 (Foxp2). PMID: 26889967
10. mice with Foxp2 mutations displayed quantitative differences in ultrasonic vocalizations as compared to wild-types PMID: 26566793
11. Foxp2 was elevated early after stroke (at 6h), but significantly decreased 24h after injury in both the nucleus and the cytoplasm; neuronal Foxp2 expression increased in stroke mice compared to sham animals 4 weeks after injury PMID: 25644653
12. arkypallidal GPe neurons originate from lateral/caudal ganglionic eminences, express the transcription factor FoxP2, fire at low rates during rest, and encode movements with robust increases in firing. PMID: 25843402
13. Results suggest that Foxp2 regulates multiple aspects of neuronal development in the embryonic forebrain PMID: 24453072
14. Foxp2 in Purkinje cells may pertain to the brain network engaged in ultrasonic vocalization (USV) modification, including USV duration, but not USV production PMID: 24607928
15. results indicate that FOXP2 is critical for the function of striatal circuits. PMID: 21876543
16. These results support the idea that FoxP2 regulates the transition from neural precursors to transit-amplifying progenitors and ultimately neurons, and shed light upon the molecular changes that might contribute to evolution of the mammalian cortex. PMID: 23283338
17. Results uncover a new layer of control of Foxp2 expression that may be required for proper neuronal maturation. PMID: 22874921
18. Foxp2(R552H) knock-in mouse pups exhibit impaired ultrasonic vocalization and poor dendritic development in Purkinje cells. PMID: 21985339
19. FoxP2 is highly expressed in virtually all Purkinje cells in cerebellum at and before postnatal day 6, except for those in the flocculus and small parts of the nodulus. PMID: 21935935
20. our study of etiological Foxp2 mutations in mice has revealed novel cognitive deficits that go beyond motor functions and extend to auditory-motor association learning. PMID: 22412993
21. Results suggest that although the Foxp2 transcription factor does not target Cadm1, Cadm1 at the synapses of Purkinje cells and parallel fibers is necessary for ultrasonic vocalization (USV) function. PMID: 22272290
22. these observations suggest that Foxp2 may regulate ultrasonic vocalization by associating with CtBP in Purkinje cells PMID: 22133810
23. Foxp2 regulates putative target gene expression and neurite outgrowth in neurons in the developing brain. PMID: 21765815
24. Foxp2 is not essential for the innate production of emotional vocalizations with largely normal acoustic properties by mouse pups. PMID: 20132318
25. The Foxp2 protein is expressed in the growing distal edge of airway epithelium. When the bronchiolus elongates, Foxp2 suppresses CC10 expression PMID: 20553735
26. Foxp2 mRNA is most highly expressed in developing and mature basal ganglia and is also observed in the cerebral cortex, cerebellum (Purkinje neurons), and thalamus. PMID: 12687690
27. Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene. PMID: 15983371
28. This review describes investigations of FoxP2 in mice and humans used for discovery of the neural bases of vocal learning and language. PMID: 17035521
29. Data show that direct interaction between Foxp2 and Nkx2.1 inhibits Nkx2.1 DNA-binding and transcriptional activity and suggest a mechanism for down-regulation of SP-C during transition of AT2 cells to an AT1 cell phenotype. PMID: 18239190
30. Ultrasonic vocalization impairment in Foxp2 (R552H) knockin mice is related to speech-language disorder and abnormality of Purkinje cells. PMID: 18287060
31. R552H heterozygotes display significant deficits in species-typical motor-skill learning, accompanied by abnormal synaptic plasticity in striatal and cerebellar neural circuits. PMID: 18328704
32. mutation causes deficits in motor-skill learning and abnormal properties of neural circuits that contribute to these skills PMID: 18430631
33. FOXP2 has a role in speech and language [review] PMID: 19304338
34. the R552H mutation uncovers possible roles for Foxp2 in the development and/or function of the auditory system. PMID: 19596273
35. These findings identify roles for two differentially expressed genes, Zic4 and Foxp2, in the development of the principal auditory relay nucleus, the medial geniculate nucleus, and principal visual relay nucleus, the lateral geniculate nucleus PMID: 19864579
36. FOXP2/foxp2 is expressed in several structures in developing human/mouse brain including cortical plate, basal ganglia, thalamus, inferior olives and cerebellum. These data suggest a conserved mammalian role in development of motor-related neural circuits PMID: 12876151

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KEGG: mmu:114142

STRING: 10090.ENSMUSP00000031545

UniGene: Mm.332919