Recombinant Mouse Gamma-aminobutyric acid receptor subunit alpha-2 (Gabra2), partial

1. Gabra2-1 mice display spontaneous seizures during development, accompanied by early mortality PMID: 30087324
2. At a lower concentration of fluoxetine and its active metabolite norfluoxetine (that is in the therapeutic range), study observed anxiogenic- and depressive-like actions in alpha2 knock-out mice, but not in alpha2+/+ mice, suggesting that in 129x1/SvJ mice a decrease in alpha2-containing GABAARs promotes an increased sensitivity to the prodepressant-like effects of chronic fluoxetine treatment. PMID: 28587819
3. Findings suggest that ovarian cycle-related progesterone and neurosteroids regulate alpha2-GABA-A receptor expression in the hippocampus via a non-progesterone receptor pathway, which may be relevant to menstrual-cycle related brain conditions. PMID: 28137424
4. Results show that the expression levels of Gabra2, as well as of GABA receptor-mediated inhibitory neurotransmission, are reduced in Shank2 e6-7, but not in e7 KO mice compared with their own wild type littermates. Shank2 e6-7 KO mice treated with allosteric modulator for the GABAA receptor reverses spatial memory deficits, indicating that reduced inhibitory neurotransmission may cause memory deficits in Shank2. PMID: 27544825
5. role for: (i) H101 in species-typical binge-like drinking, (ii) Q241 in escalated chronic drinking, and (iii) S270 and/or L277 in the development of forced abstinence-associated social deficits PMID: 27717041
6. Pharmological manipulation by clobazam, a common anticonvulsant with preferential affinity for the GABRA2 receptor, revealed dose-dependent protection against hyperthermia-induced seizures in Scn1a+/- mice. These findings support Gabra2 as a genetic modifier of the Scn1a+/- mouse model of Dravet syndrome. PMID: 27768696
7. Results indicate that 174 proteins were associated with gamma-aminobutyric acid receptor subunit alpha 2 (pHalpha2). PMID: 27044742
8. whilst not directly involved in reward perception, the alpha2- subunit may be involved in modulating the "energising" aspect of cocaine's effects on reward-seeking. PMID: 24481569
9. Wild-type and mutant mice have similar baseline nociceptive sensitivities and develop similar hyperalgesia specifically targeting alpha2-GABAA receptors which exert their antihyperalgesic effect through enhanced spinal nociceptive control. PMID: 24045508
10. GABRA2 subunit expression in hippocampus modulates neurogenesis through nuclear factor of activated T cell (NFATc)4 activity. PMID: 24948817
11. Disrupting the clustering of GABAA receptor alpha2 subunits in the frontal cortex leads to reduced gamma-power and cognitive deficits. PMID: 24043839
12. Recovery of function following alcoholic intoxication is regulated by Gabra2 and Gabra3 receptor subunits. PMID: 23147414
13. These findings suggest that alpha2-containing GABA(A) receptors expressed in the CA3 region provide the inhibition that controls hippocampal rhythm during cholinergically induced oscillations PMID: 23109109
14. The findings of this study implicated alpha2 and alpha3 subunit containing GABA(A) receptors as key mediators of the reward-related effects of benzodiazepines PMID: 22763624
15. The results of this study emphasize the critical role of GABAergic synaptic signaling for structural maturation of adult-born GCs and formation of glutamatergic synapses. PMID: 22745509
16. Data suggest that the availability of distinct GABA(A) R subtypes (Gabra2, -4, and Gabrd) provides a molecular mechanism endowing spatiotemporal specificity to GABAergic control of neuronal maturation in adult brain. PMID: 21722213
17. Data show that L. rhamnosus (JB-1) reduced GABA(Aalpha2) mRNA expression in the prefrontal cortex and amygdala, but increased GABA(Aalpha2) in the hippocampus. PMID: 21876150
18. presynaptic GABAA receptors residing on the axons or terminals of primary nociceptors play a significant role in spinal pain control. PMID: 21632935
19. Arc and Fos, increased about 250% in the alpha2 mutants, Behavioral effects (loss of righting reflex, rotarod) of flurazepam and pentobarbital were not different between alpha2 mutants and wild-type, but they were enhanced for alpha1 knock-in mice. PMID: 21056629
20. results show that alpha 2-containing GABAA receptors represent a specific molecular substrate that can regulate depressive-like states. PMID: 20965216
21. alpha2-containing GABA(A) receptors are important for specific behavioral effects of ethanol that may be relevant to the genetic linkage of this subunit to alcoholism. PMID: 20876231
22. activation of alpha2-GABA(A) receptors is both necessary and sufficient for behavioral sensitization. PMID: 20133874
23. Hybridization signals for the alpha2 mRNAs first appeared in the differentiating zone at embryonic day 13 (E13). And was detected in the migrating and differentiating granule cells and cerebellar nucleus neurons until postnatal day 14 (P14). PMID: 14766194
24. Prenatal exposure to diazepam alters both normal breathing and respiratory response to hypoxia by affecting gene expression of Gabra2. PMID: 18085262
25. Prostaglandin E2 attenuates preoptic expression of GABAA receptors via EP3 receptors PMID: 18292084
26. Dimensional anxiety mediates linkage of GABRA2 haplotypes with alcoholism.The GABAAalpha2 receptor gene (GABRA2) modulates anxiety and stress response. PMID: 16874763

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KEGG: mmu:14395

STRING: 10090.ENSMUSP00000000572

UniGene: Mm.5304