Recombinant Mouse Glutamate receptor delta-2 subunit (Grid2), partial

1. Results suggest that the GluRdelta2 receptor plays an important role in the long-term organization of the granule-Purkinje cell circuit through its involvement in the regulation of parallel fiber-Purkinje cell synaptogenesis and in the normal functioning of this critical cerebellar circuit. PMID: 26607150
2. The GluD2 mutation in the ho15J mice affects stable retention of the acquired conditioned bradycardia. PMID: 27820843
3. Notably, the introduction of GLUD2 did not affect glutamate levels in mice, consistent with observations in the primates. Instead, the metabolic effects of GLUD2 center on the tricarboxylic acid cycle, suggesting that GLUD2 affects carbon flux during early brain development, possibly supporting lipid biosynthesis. PMID: 27118840
4. This study showed that spontaneous Grid2 mutations causing cerebellar pathology are impaired in motor functions during the neonatal period. PMID: 25907855
5. Established is a mouse line with an autosomal recessive gene mutation characterized by progressive ataxia and significant cerebellar atrophy. PMID: 25250835
6. GluD2 works in concert with GluD1 for the construction of cerebellar synaptic wiring through distinct neuronal and synaptic expressions. PMID: 24872547
7. Climbing fiber signals in Glu2 receptor delta2 knock-out mice propagate across multiple microzones. PMID: 23970854
8. GluD2 deletion impairs presynaptic R-type voltage-gated Ca(2+) channels, resulting in decreased release of synaptic vesicles PMID: 23564161
9. The results suggest that multiple PC death pathways are induced by the physical trauma of making organotypic slice cultures, naturally-occurring postnatal cell death, and the GluRdelta2 (Lc) mutation. PMID: 23136008
10. activity-dependent phosphorylation of serine 880 (S880) in GluA2 AMPA receptor subunit, which is an essential step for AMPA receptor endocytosis during LTD induction, was impaired in GluD2-null cerebellum PMID: 23431139
11. GluRdelta2 is part of the mGluR1 signaling complex needed for cerebellar synaptic function and motor coordination PMID: 23115168
12. [review] GluRdelta2 plays critical roles in formation, maturation, and/or maintenance of granule neuron-Purkinje neuron synapses. PMID: 20387025
13. These results indicate that glial D-Ser regulates synaptic plasticity and cerebellar functions by interacting with GluD2. PMID: 21460832
14. GluRdelta2 fuels heterosynaptic competition and gives purkinje fibers the competitive advantages over climbing fibers throughout the animal's life. PMID: 21068325
15. The mouse interferon-inducible gene Ifi204 product interacts with this protein, a component of the nuclear pore complex. PMID: 12513910
16. GluRdelta2 and AMPA or kainate receptors can assemble to form heteromeric receptors in vitro and could modify glutamate signaling in vivo. PMID: 12573530
17. deleted N-terminal regions are crucial for oligomerization of delta2 receptors and their subsequent transport to the cell surface of Purkinje cells PMID: 12752376
18. Antibody induced AMPA receptor endocytosis, attenuated synaptic transmission and abrogated long-term depression. Injection of antibody into subarachnoidal supracerebellar space caused cerebellar dysfunction, ataxic gait, and poor rotorod performance. PMID: 12833050
19. mechanism that controls iGluR subunit assembly seems to involve the extracellular N-terminal domain where the hotfoot mutation is located. PMID: 12862360
20. Glurdelta2 subunit deficiency in mice produces involuntary spontaneous eye movement with characteristic 10 Hz oscillating activity originating in Purkinje neurons by enhancing climbing fiber inputs PMID: 15014119
21. through Shank1 and Shank2, GluRdelta2 interacts with the metabotropic GluR1alpha, the AMPA-type GluR, and the inositol 1,4,5-trisphosphate receptor (IP3R) that are essential for cerebellar LTD. PMID: 15207857
22. GluRdelta2 is implicated in induction of long-term depression. Enhanced climbing fiber activity in delta2-/-mice potentiates IPSC amplitudes in Purkinje neurons through rebound potentiation in vivo, resulting in the prevention of additional RP induction. PMID: 15574740
23. a mutant GluRdelta2 transgene, as well as a wild-type GluRdelta2 transgene, rescued all abnormal phenotypes of delta2(-/-) mice PMID: 15592450
24. two new mutations, 153Gso and 154Gso, associated with reciprocal translocations with a common breakpoint in chromosome 6B3 are described; these mutations disrupt the Grid2 gene at sites located more than 100 kb apart in intron 6 and intron 4 of the gene. PMID: 15674731
25. Postsynaptic GluRdelta2 is a key regulator of the presynaptic active zone & postsynaptic density organization at parallel fiber-Purkinje-cell synapses in the adult brain. PMID: 15728855
26. the total hippocampal theta activity (4-12 Hz) of GluRdelta2 mutant mice was less than that of wild-type mice PMID: 16271355
27. These results indicate that 865-871 aa of GluRdelta2 are essential for both LTD and interaction with PICK1, and suggest that interaction between GluRdelta2 and PICK1 might be critical for the induction of LTD. PMID: 16597715
28. the E2 region of GluRdelta2 is necessary, and also sufficient, to inhibit endocytosis of the receptor from postsynaptic membranes PMID: 16636065
29. There were more interneurons in the molecular layer of the Grid2Lc/+;Bax(-/-) mice compared to Grid2Lc/+, suggesting that interneurons are subject to a BAX-dependent target-related death in the Lurcher mutants. PMID: 16739195
30. the conserved glutamine residue in the channel pore, which is crucial for all Ca2+-permeable glutamate receptors, is not essential for the function of GluRdelta2 PMID: 17255161
31. GluRdelta2 knockout mice show ataxia and impaired motor coordination, suggesting that the presence of GluRdelta2 plays an important role in controlling cerebellar functioning. PMID: 17604104
32. does not serve as a channel in the regulation of cerebellar long-term depression induction PMID: 17702810
33. GluRdelta2 ligand-binding core is capable of binding ligands and cleft closure of the ligand-binding core can induce conformational changes that alter ion permeation. PMID: 17715062
34. Long-term depression induction and motor learning are regulated by signaling via the C-terminal end of GluRdelta2. PMID: 18256267
35. Data show that mice lacking GRID2 moleculars display ataxia gaits. PMID: 18418877
36. Rora(sg) mutants with mild cerebellar granule cell degeneration were compared to Grid2(ho) mutants with more severe granule cell degeneration as well as Purkinle cell atrophy for left-right and dark-light discrimination learning tasks in a water T-maze. PMID: 18583162
37. Ser945, a major PKC phosphorylation site of of GluRdelta2, may not play a crucial role in induction of long-term depression in the cerebellum PMID: 18677091
38. The delta glutamate receptor subfamily can induce the differentiation of glutamatergic presynaptic terminals and contribute to the establishment of synaptic transmission. PMID: 19258455
39. These results support the conclusion that the Lurcher mutation in GluRdelta2 induces cell autonomous defects in differentiation and survival. PMID: 19294643
40. These results suggest that the extracellular N-terminal domain and intracellular C-terminal domainare critical domains of GluRdelta2 PMID: 19614753

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KEGG: mmu:14804

STRING: 10090.ENSMUSP00000093536

UniGene: Mm.439651