Recombinant Mouse Glycine receptor subunit alpha-1 (Glra1), partial

1. These findings suggest that spinal alpha1 GlyR is a potential target for cannabinoid analgesia in chronic inflammatory pain. PMID: 29407767
2. The results of this study suggested that the Glra1 activation can regulate receptor diffusion and cluster size at inhibitory synapses in mature stage, providing not only new insights into the postsynaptic mechanism of shifting inhibitory neurotransmission but also the inhibitory synaptic plasticity in mature nervous system PMID: 28197549
3. Glra1 receptor Beta8-Beta9 loop is an essential regulator of conformational rearrangements in ion channel opening and closing. PMID: 28724750
4. Absence of GlyRalpha1 input unmasked a serial and a direct feedforward GABAAergic modulation in PV5 RGCs, reflecting a complex interaction between glycinergic and GABAAergic inhibition. PMID: 25231618
5. Results suggest an important function of alpha1 GlyR on sedative effects of ethanol and confirms the role of KK385-386 residues in these effects PMID: 24801766
6. Meanwhile, neonatal incision significantly decreased the density of tonic GlyR-mediated current only in the presumed glutamatergic population during adulthood. PMID: 23639821
7. Histamine is an inverse agonist at strychnine sensitive glycine receptors. PMID: 23603522
8. Mutation of a zinc-binding residue in the glycine receptor alpha1 changes ethanol sensitivity in vitro and alcohol consumption in Glra1(D80A) knock-in mice. PMID: 23230213
9. TM3-4 loop subdomains are important for functional reconstitution of glycine receptors by independent domains PMID: 22995908
10. The distinct developmental regulation of GlyRalpha1 in the murine cochlea advocates a contribution of these chloride channels to efferent olivocochlear innervation. PMID: 21850450
11. Mutations in the GlyR alpha-1 subunit, M287L and Q266I, resulted in a small but general impairment of glycine action, that is most evident in the glycine-induced maximal currents. PMID: 22037201
12. Mutations in the GlyR alpha-1 subunit, M287L and Q266I, decreased specific behavioral actions of ethanol and altered other nonethanol behaviors, demonstrating the importance of GlyR function in diverse neuronal systems. PMID: 22037202
13. these data suggest most glycine receptors and glycinergic synapses in the superficial dorsal horn contain alpha1 subunits and few are composed exclusively of alpha3 subunits. PMID: 21486794
14. The values of breathing frequency, tidal volume, and minute ventilation in newborn Glra1-deficient oscillator mice decrease rapidly during postnatal development. PMID: 12380014
15. The new Glra1 mutation appears to affect glycine's inhibitory neurotransmission in the central nervous system (CNS) of the nmf11 homozygotes, which suffer from a severe startle disease-related phenotype and die by postnatal day 21. PMID: 16964444
16. Thus, the hyperekplexia phenotype of Glra1(D80A) mice is due to the loss of Zn(2+) potentiation of alpha1 subunit containing GlyRs, indicating that synaptic Zn(2+) is essential for proper in vivo functioning of glycinergic neurotransmission. PMID: 17114051
17. These results show that insulin has a novel regulatory action on the potency of glycine for ionotropic glycine receptors. PMID: 17308032
18. Our results suggest crosstalk between postsynaptic and presynaptic elements, leading to the developmental regulation of the presynaptic terminal neurotransmitter content according to the level of postsynaptic GlyR aggregation. PMID: 18445051

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KEGG: mmu:14654

STRING: 10090.ENSMUSP00000099777

UniGene: Mm.89320