Recombinant Mouse Integrin alpha-X(Itgax),partial

In Stock
Code CSB-BP874106MO1
Size US$1478 How to order?
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

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Product Details

Purity Greater than 85% as determined by SDS-PAGE.
Target Names Itgax
Uniprot No. Q9QXH4
Research Area Immunology
Alternative Names Itgax; Integrin alpha-X; CD11 antigen-like family member C; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD antigen CD11c
Species Mus musculus (Mouse)
Source Baculovirus
Expression Region 20-1116aa
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 165.4 kDa
Protein Length Partial
Tag Info N-terminal MBP-tagged and C-terminal 6xHis-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time 3-7 business days
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

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Target Background

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
Gene References into Functions
  1. CD11c and its partner Itgb2 were required for DC capture of CD47-deficient cells. CD11b was not necessary for this process but could partially compensate in the absence of CD11c. Mice with DCs lacking Talin1, Itgb2, or CD11c were defective in supporting T-cell proliferation and differentiation induced by CD47-deficient cell associated antigen. PMID: 29891680
  2. alphaXbeta2 uses the alphaX alphaI domain to bind iC3b on its C3c moiety at one of two sites. PMID: 28292891
  3. Accumulation of lung CD11c+ DCs is significantly higher in both inflammatory and fibrotic phases of the disease but that percentages got reduced in the absence of TGF-beta. PMID: 28557137
  4. The findings of this study indicate that radio-resistant cells, expressing CD11c-GFP+ and located in the CNS, irrespective of their origin, which might be the yolk sac or the periphery, show a phenotype capable of antigen presentation under neuroinflammatory conditions following induction of EAE. PMID: 28421248
  5. These data demonstrated that the CD11c+ lamina propria mononuclear phagocytes from this postinfectious irritable bowel syndrome mouse model were not only able to transfer enteric inflammation to the normal mice but also caused abnormal intestinal function, characterized by epithelial barrier disruption and visceral hyperalgesia. PMID: 28440501
  6. the CD11c promoter was unexpectedly active and triggered Mgat2 deletion within multiple hematopoietic lineages, showed remarkably poor penetrance within native DC populations, and produced almost undetectable levels of green fluorescent protein signal. These findings show that the CD11c promoter is not DC-specific, and extreme care should be taken in the interpretation of data using any mouse created using the CD11c-CRE PMID: 27146521
  7. Studies indicate that the autoimmune phenotype in DEF6 and SWAP-70 knock-out (DKO) mice is characterized by the accumulation of B cell subset that expresses high levels of CD11c and T-bet (ABCs). PMID: 28780965
  8. MyD88 signaling in lysozyme M and CD11c-expressing myeloid cells, as well as in pulmonary epithelial cells, is critical to restore inflammatory cytokine and antimicrobial peptide production, leading to efficient neutrophil recruitment and enhanced bacterial clearance. PMID: 26627460
  9. Results implicate a monocytic origin of CD11c(+) cells in inflamed islets and suggest that therapeutic regulatory T cells directly or indirectly regulate their influx by altering the chemotactic milieu in the islets. PMID: 28550204
  10. Murine CD11c+ T cells analyzed by flow cytometry display markers associated with non-conventional T cell subsets, including gammadelta T cells and invariant natural killer T (iNKT) cells. PMID: 27119555
  11. Data concluded that the ablation of CD11c(hi) dendritic cells provided a subsidiary impact on blood-brain barrier (BBB) integrity and the expression of tight junction/adhesion molecules, thereby leading to exacerbated Japanese encephalitis (JE) progression. PMID: 27638116
  12. CD11c(+) monocyte/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23. PMID: 26242598
  13. data demonstrate that CD11c(hi) DCs provide a critical and unexpected role to preserve the immune-privileged CNS in lethal neuroinflammation via regulating the differentiation, function, and trafficking of CD11b(+)Ly-6C(hi) monocytes. PMID: 26626303
  14. The generation of mouse line with Flip deficiency in cells that express cre under the CD11c promoter is reported. PMID: 25963626
  15. Probucol effectively retarded atherosclerosis at least partly through lipid-lowering and inhibiting immune maturation of CD11c dendritic cells in STZ-induced diabetic LDLR mice. PMID: 25714599
  16. Dual function of PPARgamma in CD11c+ cells ensures immune tolerance in the airways. PMID: 26062999
  17. CD11c-expressing B cells are located at the T cell/B cell border in spleen and are potent antigen-presenting cells. PMID: 26034175
  18. Our findings suggest that increased numbers of CD11c(+) macrophages and elevated levels of TNF-alpha and MMP-3 in AT and ST may explain the relationship between hyperlipidaemia and OA. PMID: 25693634
  19. Selective ablation of ICOSL in CD11c+ cells, but not in B cells, dramatically ameliorates kidney and lung inflammation in lupus-prone transgenic mice. PMID: 25786178
  20. the role of the aryl hydrocarbon receptor in the function of CD11c cells during respiratory viral infection. PMID: 24519489
  21. provide new insight into how CD11c(+) cells regulate the lymph node vascular-stromal compartment, add to the evolving understanding of functional stromal subsets PMID: 24659690
  22. Data indicate taht tumor necrosis factor receptor superfamily member 14 (TNFRSF14)participated in ovariectomy (OVX)-induced adipose tissue (AT) inflammation via upregulation of CD11c, resulting in metabolic perturbation. PMID: 24287621
  23. The findings identify CD11c macrophages in the lung are likely an important source of IL-23 during ALI, which may be helpful for better understanding of this disease. PMID: 23481504
  24. CD11c+ dendritic cells are essential for de novo induction of Foxp3 expression in naive CD4+ T cells and for airway tolerance. PMID: 23733880
  25. Approximately 26.6% of the cells in DC+ fraction co-expressed CD11c+ and F4/80 markers. PMID: 23146677
  26. Data conclude that both GM-CSF and FLT3L act through PU.1 to activate the 5.3 Kb CD11c proximal promoter in DCs and to induce differentiation of monocyte-derived DCs. PMID: 23284905
  27. down-regulated upon dendritic cell activation through Toll-like receptor triggering PMID: 22445076
  28. Data indicate the amounts of Ptpn6 (Shp1) and MyD88 protein were reduced in dendritic cells of Ptpn6fl/flMyd88fl/flItgax-cre mice. PMID: 23521885
  29. IRF7 regulates TLR2-mediated activation of splenic CD11c(hi) dendritic cells PMID: 22815909
  30. AP-1 composed with JunD and Fra2 protein plays a primary role in enhancing the transcription level of the CD11c gene in dendritic cells PMID: 22990073
  31. CD11c+ cells produce cytokines and/or chemokines required for VCAM-1 upregulation on lung endothelium, which in turn is crucial for Cd11c+ induced mast cell progenitor recruitment and an increase in mast cell numbers. PMID: 22972929
  32. This study showed that, while CD11c(high) DCs initiate helminth-specific adaptive immunity, innate type 2 cells are able to mount an autonomous response to the challenge of parasite infection. PMID: 22851746
  33. airway epithelial NF-kappaB activation is a critical modulator of the adaptive immune response to inhaled antigens via soluble mediator secretion to affect the capacity of CD11c(+) cells to undergo maturation and promote antigen-specific allergic responses PMID: 20581095
  34. Residential macrophages require integrin alphaXbeta2 to control Candida albicans invasion of the brain in vivo. PMID: 22844116
  35. A model where CD23(+) B cells act as antigen transporting cells, delivering antigen to CD11c(+) cells for presentation to T cells is consistent with available experimental data. PMID: 21765910
  36. Our studies provide for the first time evidence that CD11c expression may abrogate the ability to reduce primary virus replication in the eye and TG via higher activities of type 1 interferon and CD8(+) T cell responses. PMID: 21775452
  37. Small intestine CD11c+ CD8+ T cells suppress CD4+ T cell-induced immune colitis. PMID: 21436315
  38. Data show that telmisartan reduced the mRNA expression of CD11c and TNF-alpha, M1 macrophage markers, and significantly increased the expressions of M2 markers, such as CD163, CD209. PMID: 21427223
  39. Depletion of kidney CD11c+ F4/80+ cells impairs the recovery process in ischaemia/reperfusion-induced acute kidney injury. PMID: 20388633
  40. Pulmonary CD11c+ cells are critical for NO2-promoted allergic sensitization via antigenspecifici CD4+ T-cell polarization. PMID: 20659336
  41. findings point to role for CR4 on dendritic cells in triggering B cells during humoral immunity PMID: 20465572
  42. CD11c-positive dendritic cells make a critical downstream contribution to anti-death receptor (DR)5 antitumor activity. PMID: 20505139
  43. CD11c-positive M1-like ATMs can exhibit phenotypic plasticity and that the polarization of these cells between inflammatory and non-inflammatory states is well correlated to the presence of absence of insulin resistance PMID: 20308074
  44. Dendritic cells expressing CD11c and class II major histocompatibility antigens promote high endothelial cell quiescence in vitro and, in vivo, mediate quiescence in expanded lymph nodes. PMID: 20231692
  45. These data demonstrate that CD11c(+) cells play a critical role in protecting the organs from systemic injury caused by a pulmonary endotoxin challenge. PMID: 19948830
  46. Diet-induced obesity increased CD11c in both adipose tissue and blood. PMID: 19910635
  47. CD11c is a useful marker for detection and isolation of pulmonary antiviral cytotoxic T cells following RSV infection. PMID: 16011799
  48. 4-1BB stimulation enhanced both primary and memory anti-herpesvirus-1 CD8+ T cell responses, which was mediated by a massive expansion of antigen-specific CD11c+CD8+ T cells PMID: 16524567
  49. CD11c+ dendritic cells-derived osteoclasts are capable of inducing bone loss after adoptive transfer in vivo PMID: 16920972
  50. Results indicate that expression of p150/95 is critical on both T cells as well as other leukocytes for the development of demyelinating disease and may represent a novel therapeutic target for multiple sclerosis. PMID: 17525267

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Subcellular Location Membrane; Single-pass type I membrane protein.
Protein Families Integrin alpha chain family
Database Links

KEGG: mmu:16411

STRING: 10090.ENSMUSP00000033053

UniGene: Mm.22378

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