Recombinant Mouse Interleukin-1 receptor-associated kinase 1-binding protein 1 (Irak1bp1)

Code CSB-YP863673MO
MSDS
Size Pls inquire
Source Yeast
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP863673MO
MSDS
Size Pls inquire
Source E.coli
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP863673MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-BP863673MO
MSDS
Size Pls inquire
Source Baculovirus
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-MP863673MO
MSDS
Size Pls inquire
Source Mammalian cell
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Purity
>85% (SDS-PAGE)
Target Names
Irak1bp1
Uniprot No.
Alternative Names
Irak1bp1; Aip70; Simpl; Interleukin-1 receptor-associated kinase 1-binding protein 1; IRAK1-binding protein 1; ActA-binding protein 70; PLK-interacting protein; Signaling molecule that associates with the mouse pelle-like kinase; SIMPL
Species
Mus musculus (Mouse)
Expression Region
1-259
Target Protein Sequence
MSLQPAPASR VFMELVPWAD RGRENHPISA AEAQPIGRRP HVAEAHPGAR EVHVSGAAEV SASPDRALVT VRVSSTKEVS AEAKKSVCRR LDYITQSLQQ QGFQAENVTV TKNIRRVENA YHMEAEVCIT FTEFGKMQNI CNFLVEKLDS SVVISPPEFY HTPGSVENLR RQACLVAVEN AWRKAQEVCD LVGQTLGKPL LIKEEETKDW EGQTDDHQLS RLPGTLTVQQ KIKSATIHAA SKVFITFEVK GKEKKKKHL
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity.
Gene References into Functions
  1. SIMPL functions as a TNFalpha-dependent p65 co-activator by facilitating the recruitment of MED1 to p65 containing transcriptional complexes to control the expression of a subset of TNFalpha-induced genes. PMID: 23630580
  2. IRAK1BP1 functions through its effects on NF-kappaB as a molecular switch to bias innate immune pathways toward the resolution of inflammation PMID: 20534545
  3. Signals transduced through the tumor necrosis factor-alpha-tumor necrosis factor -receptor I-SIMPL(substrate that interacts with mouse pelle-like kinase) pathway support hematopoietic progenitor cell survival, growth and differentiation PMID: 19941935
  4. TNF-alpha activation of NF-kappaB dependent-gene expression requires nuclear relocalization of p65 as well as nuclear relocalization of SIMPL, generating a TNF-alpha-specific induction of gene expression. PMID: 15485901
  5. Hsp70/Hsc70 bind the intrinsically disordered amino-terminal region of SIMPL to stabilize the protein and thereby regulate its activity. PMID: 17233114
  6. IRAK1BP1 regulates transcription of a specific subset of Toll-like receptor responsive genes, producing an overall antiinflammatory profile PMID: 18268037

Show More

Hide All

Subcellular Location
Cytoplasm. Nucleus.
Protein Families
IRAK1BP1 family
Tissue Specificity
Expressed in testis, brain, kidney, liver and heart.
Database Links
icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1