Product Details

Purity

>85% (SDS-PAGE)

Target Names

Kirrel3

Uniprot No.

Q8BR86

Alternative Names

Kirrel3; Kiaa1867; Neph2Kin of IRRE-like protein 3; Kin of irregular chiasm-like protein 3; Nephrin-like protein 2; mKirre) [Cleaved into: Processed kin of IRRE-like protein 3]

Species

Mus musculus (Mouse)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells.

Gene References into Functions

Findings provide evidence that Kirrel3(-/-) mice exhibit autistic-like behaviors, including social and communicative deficits, repetitive behaviors, and sensory abnormalities, as well as hyperactivity. PMID: 29362445
This study demonstrated that selective loss of mossy fiber filopodial synapses with GABA neurons likely underlies the hippocampal activity imbalance observed in Kirrel3 knockout mice and may impact neural function in patients with Kirrel3-dependent neurodevelopmental disorders. PMID: 28670619
mouse Kirrel3 is a myobast adhesion molecule which promotes the morphological change of rounded MPC to a spindle shaped myocyte that migrates in a directed fashion and participates in the tight interactions between myocytes prior to their fusion PMID: 28621431
Kirrel3 is required for formation of hippocampal mossy fiber filopodia; the structures that give rise to dentate granule-GABA synapses and that regulate feed-forward inhibition of CA3 neurons. PMID: 26575286
Kirrel3 has a role in coalescence of vomeronasal sensory neuron axons into glomeruli and in male-male aggression in a resident-intruder assay PMID: 23637329
Here we demonstrate that Neph1, Neph2, and Neph3 are expressed differentially in various tissues during ontogenesis in mouse and chicken. PMID: 22205279
Results suggest Neph2 is involved in the nucleogenesis of the pontine nucleus through the control of neuronal migration inside the nucleus. PMID: 21241806
involved in the hematopoietic supportive capacity of OP9 mouse stromal cells PMID: 12665856
The spatiotemporal expression pattern of mKirre mRNA suggests important roles of mKirre in later developmental processes, especially the synapse formation. PMID: 15908127
In the adult brain, Neph2 is seen in the olfactory nerve layer and the glomerular layer of the olfactory bulb, in the hippocampus, and in cerebellar Purkinje cells. At the ultrastructural level, Neph2 is seen in dendritic shafts of pyramidal neurons. PMID: 16874800
These results suggest that mKirre may be involved in the establishment of the pathway from sensory organs to the brain. PMID: 18022324

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Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite.; [Processed kin of IRRE-like protein 3]: Secreted.

Protein Families

Immunoglobulin superfamily

Tissue Specificity

Expressed mainly in adult brain, bone marrow and stromal cells. Expressed in diverse regions of the brain, including the cortex, hippocampus, striatum, olfactory bulb and cerebellum. In brain, expressed in pontine nucleus neurons (at protein level). In hi

Database Links

KEGG: mmu:67703

STRING: 10090.ENSMUSP00000110801

UniGene: Mm.220710

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Recombinant Mouse Kin of IRRE-like protein 3 (Kirrel3), partial

Product Details

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Target Background

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