Recombinant Mouse Lactoylglutathione lyase (Glo1)

1. Transgenic mice overexpressing Glo1 on both FVB/NJ (FVB) or C57BL/6J (B6) backgrounds showed increased voluntary EtOH consumption compared to their wild-type littermates. Transgenic Glo1 knockdown mice on a B6 background showed decreased voluntary EtOH consumption. Genetic manipulations of Glo1 had no effect on sucrose, saccharin or water consumption. PMID: 26691867
2. the Glo1-methylglyoxal pathway integrates maternal and neural precursor cell metabolism to regulate neural development. PMID: 27760310
3. These data indicate that Glo1 knockout reduces anxiety-like behavior, but increases depression-like behavior. PMID: 28623132
4. Alternative detoxification of methylglyoxal in GLO1(-/-) is achieved by increased catalytic efficiency of aldose reductase toward hemithioacetal (product of glutathione and methylglyoxal ), which is most likely caused by S-nitrosylation of aldose reductase. PMID: 27956549
5. Glo1 knockdown does not have major short term effects on the energy expenditure or the formation of atherosclerotic plaques. PMID: 26788517
6. Crystal structure of the mouse Glo1-inhibitor complex was determined at 2.3 A resolution. PMID: 26279158
7. Study demonstrates that GLO1 is a novel metabolic oncogene of the 6p21 amplicon, which promotes tumor growth and aberrant transcriptional signals via regulating cellular metabolic activities for energy production. PMID: 24662817
8. Glyoxalase expression prevents against ischemic neuronal cell damage and ameliorates ischemic injury. PMID: 24252591
9. the balance between methylglyoxal and age-dependent GLO1 downregulation contributes to delayed wound healing in old mice PMID: 23797271
10. The difference in glyoxalase-1 mRNA was observed with Fkbp5-/- mice expressing 2-fold more glyoxylase-1 protein. PMID: 23733890
11. pharmacological inhibition of GLO1 reduced anxiety, suggesting that GLO1 is a possible target for the treatment of anxiety disorders. PMID: 22585572
12. These results suggest that GLO-1 plays a role in high glucose-mediated signaling by reducing mesangial cells accumulation and oxidative stress in diabetes mellitus. PMID: 22036650
13. Findings reveal that the abundance of GLO1 varies between different murine strains and within different sensory neuron populations. PMID: 21633909
14. Data show that reducing RGS2 expression by antisense treatment prevented the increase in GLO1 and GSR1 mRNA and protein expression. PMID: 21510939
15. Data demonstrate GLO1 expression and glycation damage to be induced by alpha-synuclein ablation leading to the suggestion that wild-type alpha-synuclein modulates brain glucose metabolism. PMID: 20711648
16. Glo-I is a novel molecular target for treatment of Bcr-Abl(+) leukemias, and Abl TKI-resistant quiescent Bcr-Abl(+) leukemic cells that have acquired stem-like characteristics in the process of adapting to a hypoxic environment. PMID: 20139893
17. Tumor necrosis factor-induced modulation of glyoxalase I activities through phosphorylation by PKA results in cell death and is accompanied by the formation of a specific methylglyoxal-derived AGE. PMID: 11792832
18. Local overexpression in the mouse brain resulted in increased anxiety-like behaviour; Glo1 is involved in oxidative stress metabolism, linking this pathway with anxiety-related behaviour PMID: 16244648
19. In diabetes there is an upregulation of glyoxalase I, but this upregulation is inadequate to normalize MGO levels, which could lead to MGO retention and chemical modification of proteins. PMID: 16583141
20. Glo1 expression was upregulated in liver and hypothalamus of congenic mice when compared with B6 mice PMID: 16946080
21. Expression of 40 proteins, including the antioxidative enzymes peroxiredoxin 1 and 3, glutathione peroxidase 1, and SOD-1, was increased with diabetes, suggesting an adaptive response to oxidative stress associated with this diabetic model. PMID: 17609286
22. methyl-gerfelin targets GLO1, resulting in the inhibition of osteoclastogenesis PMID: 18695250
23. findings provide a molecular basis for differential expression of Glo1 and further implicate Glo1 in anxiety-like behavior PMID: 19266052

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KEGG: mmu:109801

STRING: 10090.ENSMUSP00000024823

UniGene: Mm.261984