Recombinant Mouse Low affinity cationic amino acid transporter 2 (Slc7a2), partial

1. In the absence of CAT2, Myeloid-derived suppressor cells display diminished capacity for controlling T cell immunity in prostate inflammation and cancer models, where the loss of CAT2 results in enhanced antitumor activity. PMID: 26491198
2. demonstration of how most nuclear-retained CTN-RNAs stabilize at the periphery of paraspeckles, how CTN-RNA regulates its protein-coding partner, and how the mCAT2 gene can maintain a stable expression PMID: 25619276
3. cationic transporter CAT2 plays an important role in controlling inflammation and IL-17 activation in an injury model of colitis PMID: 23703655
4. These results demonstrate that the availability of arginine, mediated by Slc7a2, controls critical aspects of macrophage activation and reveal a factor for susceptibility to Leishmania infection. PMID: 23460752
5. CAT-2A and CAT-1 L-arginine transporters are increased in cardiomyocytes from Duchenne muscular dystrophy mice. PMID: 23009292
6. CAT2 is an important regulator of the immune response during H. pylori infection. PMID: 22194986
7. Uptake of L-Arg, and its metabolism by Arg1 to L-Orn and conversion to L-Pro by OAT is essential for colonic epithelial wound repair. PMID: 22361732
8. Results identify CAT2 as a regulator of fibrotic responses in the lung. PMID: 20576117
9. IL-10 attenuated the LPS-induced upregulation of CAT-2 mRNA in macrophage cells. Results suggest that transcriptional control of CAT-2 by IL-10 regulates iNOS activity. PMID: 11829538
10. The cationic amino acid transporter 2B may regulate supply of L-arginine to iNOS. PMID: 15631944
11. We conclude that BMM present mainly y(+)L activity and that, in response to GM-CSF, l-arginine transport augments through CAT2, thereby increasing the availability of this amino acid to the cell. PMID: 16371438
12. Increased L-arginine transport mediated by both T helper cell (Th)1-type and Th2-type endogenous activators is strongly regulated by Slc7a2/CAT2 expression, which could limit the function of macrophages. PMID: 16670299
13. SLC7A2 mediates the increase in arginine transport in mouse macrophages during activition but not during proliferation. PMID: 16703566
14. These data suggest that CAT2 regulates anti-inflammatory processes in the lungs via regulation of dendritic cell activation and subsequent T cell responses. PMID: 17003120
15. CAT-2 exerts control over airway smooth muscle force development through a spermine-dependent pathway that directly correlates with the expression level of PIP-5K-gamma in the lung. PMID: 17644755
16. By controlling NOS2 and arginase activity, CAT2 functions as a potent regulator of immunity. PMID: 18369473

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KEGG: mmu:11988

STRING: 10090.ENSMUSP00000096414

UniGene: Mm.4676