Recombinant Mouse Max dimerization protein 3 (Mxd3)

Code CSB-YP015252MO
MSDS
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Source Yeast
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Code CSB-EP015252MO
MSDS
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Source E.coli
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Code CSB-EP015252MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP015252MO
MSDS
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Source Baculovirus
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Code CSB-MP015252MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Mxd3
Uniprot No.
Alternative Names
Mxd3; Mad3Max dimerization protein 3; Max dimerizer 3; Max-associated protein 3
Species
Mus musculus (Mouse)
Expression Region
1-206
Target Protein Sequence
MEPVASNIQV LLQAAEFLER REREAEHGYA SLCPHHSPGT VCRRRKPPLQ APGALNSGRS VHNELEKRRR AQLKRCLEQL RQQMPLGVDC TRYTTLSLLR RARVHIQKLE EQEQQARRLK EKLRSKQQSL QQQLEQLQGL PGARERERLR ADSLDSSGLS SERSDSDQED LEVDVESLVF GTETELLQSF SAGREHSYSH STCAWL
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation.
Gene References into Functions
  1. Mxd3 regulates preadipocyte proliferation and early adipocyte differentiation via Cebpd downregulation in vitro and in vivo. PMID: 24254064
  2. Results demonstrate that high expression levels of Mad3 in immature B cells induce Id2 expression, which inhibits transcription of genes essential for B cell differentiation. PMID: 20375148
  3. identification as a novel target for regulation by E2F1 PMID: 12444919
  4. These studies support a novel role for Mad3 in cerebellar granule neuron precursors proliferation and possibly tumorigenesis. PMID: 17893326
  5. Adenosine signaling mediates SUMO-1 modification of IkappaBalpha during hypoxia and reoxygenation. PMID: 19297320

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Subcellular Location
Nucleus.
Tissue Specificity
Expressed only in the proliferating areas of the testis and thymus.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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