Recombinant Mouse Mitochondria-eating protein(Spata18)

Code CSB-YP603906MO
Size Pls inquire other sizes
Source Yeast
Code CSB-EP603906MO
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Source E.coli
Code CSB-EP603906MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
Code CSB-BP603906MO
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Source Baculovirus
Code CSB-MP603906MO
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Source Mammalian cell

Product Details

Purity >85% (SDS-PAGE)
Target Names Spata18
Uniprot No. Q0P557
Species Mus musculus (Mouse)
Expression Region 1-537
Target Protein Sequence MAESLKKLAK SESLQALQDK VTYWVNDYNS NSCDQNLNYC IELIEQVAKV QAQLFGILTV TAQEGGNNEG VETIKCRLLP LLQTSFSSVN MGKTAESEMC ATQDFQLRSK NRDNSPDQDQ HQSDNESFSE TQPTQVQDDL AESGKSLEGA KNGSTISLLA AEEEINQLKK QLKSLQAQED ARHKTSENRR SEALKSDHRS TKRTQDQRPQ DVVSNYEKHL QNLKEEIAVL SAEKSGLQGR SARSPSPSTG TRSHRRGRSR SHSRSRSHSR SNSPCTTVAK IRSPSPNRAK MSSVARKAAL LSRFSDAYSQ ARLDAQCLLR RCIDRAETVQ RIIYIATVEA FHVAKMAFRH FKIRVRKMLT PSNVGSNTDF ETAVSEYIVC HLDLYDSQSS VNDVIRAMNV NPKISFPPEV DFCLLTDFIQ EICCIAFAMQ SLEPPLDIAF GADGEIFNDC KYRRSYDSDF TAPLVFYHVW PALMENDCVI MKGEAVTKRG AFWSSVRPVM RCRSRSLSPI CPRNHFGIST VSRSRSPSPI RCTFARY
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.
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Target Data

Function Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. May have a role in spermatogenesis, especially in cell differentiation from late elongate spermatids to mature spermatozoa (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity).
Subcellular Location Cytoplasm, Mitochondrion outer membrane
Protein Families MIEAP family
Tissue Specificity In testis, expressed primarily in spermatids.
Database Links

KEGG: mmu:73472

STRING: 10090.ENSMUSP00000064308

UniGene: Mm.87067

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