Recombinant Mouse Multidrug resistance protein 1B (Abcb1b), partial

1. this study shows that MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation PMID: 28401939
2. A panel of 18 P-gp substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp can affect the pulmonary kinetics of a subset of P-gp substrates. PMID: 28702798
3. Data suggest that the overexpression of P-gp in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl. PMID: 28671633
4. We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary. PMID: 28216407
5. Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp, multi-drug resistance protein, MDR1).Drugs with ER < 1 almost do not bind the main binding cavity (MBC) of P-gp. PMID: 27984797
6. conclusion, MDR1 and BCRP are expressed on apical membranes of the rodent placental SynT-II layer. PMID: 27616577
7. Mdr1 enforces T Cell homeostasis in the presence of intestinal bile acids. PMID: 29262351
8. Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia. PMID: 28025333
9. the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity PMID: 28283574
10. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp. PMID: 27531061
11. Chrysosplenetin inhibited P-gp activity and reverse the up-regulated P-gp and MDR1 levels induced by artemisinin. PMID: 27931149
12. Tamsulosin and tolterodine with P-gp gene expression and activity in an enantiomer-specific way. PMID: 27678410
13. Pgp-coupled ATPase activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil. PMID: 26823559
14. Data show that human transgenic mutant huntingtin (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1) which suggests that MDR1 might be a potential therapeutic target for Huntington's disease. PMID: 26586297
15. In vitro and in vivo downregulation of the ATP binding cassette transporter B1 by the HMG-CoA reductase inhibitor simvastatin PMID: 26319048
16. Efficient chemoprotection of CDD and MDR1 transduced hematopoietic 32D as well as primary lin(-) cells was proven in the context of Ara-C and anthracycline application PMID: 26651614
17. Mdr1b participates in the elimination of paraquat from the kidneys and protects against subsequent toxicity. PMID: 25015657
18. These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1-1Delta mutant mice following exposure to various P-gp substrates. PMID: 25419811
19. Data indicate that the brain penetration of ABT-888 in both Abcb1a/1b-/- and Abcb1a/1b-/-;Abcg2-/- mice was significantly higher than in wild-type mice. PMID: 24647572
20. Directed evolution of P-glycoprotein cysteines reveals site-specific, non-conservative substitutions that preserve multidrug resistance. PMID: 24825346
21. Expression of Abcb1 at the blood-brain and blood-spinal barriers is upregulated by Nrf2. PMID: 24948812
22. The improved structures of Pgp reveal important implications for polyspecific drug recognition in the form of a high concentration of aromatic residues in the drug translocation pathway that is most conserved among mammalian orthologs. PMID: 24155053
23. Real-time polymerase chain reaction for ABC transporters demonstrated that Abcb1a, Abcb1b and Abcg2, regarded as stem cell markers, were characteristically expressed in TtT/GF cells but not in Tpit/F1 and LbetaT2 cells. PMID: 23881407
24. In addition to ABCB1-mediated transport. PMID: 23616082
25. In single Bcrp1(-/-) mice, brain accumulation of CYT387 was more substantially increased than in Mdr1a/1b(-/-) mice, suggesting that CYT387 is a slightly better substrate of Bcrp1 than of Mdr1a at the blood-brain barrier. PMID: 23827160
26. In Bcrp1;Mrp2;Mrp3(-/-), but not Bcrp1;Mdr1a/b;Mrp(-/-) mice. PMID: 24334255
27. Data suggest that neither Mdr1a nor Mdr1b are involved in transepithelial transport of herbicide paraquat; brain-to-plasma partitioning ratios and total brain accumulation of paraquat were same across doses between wildtype Mdr1a/Mdr1b knockout mice. PMID: 24297779
28. These results indicate that radixin plays an important role in regulating P-glycoprotein localization and P-glycoprotein functional activity at the intestinal membrane. PMID: 23754525
29. Data indicate that Abcc4 limits the brain penetration of camptothecin analogues and teams up with Abcb1a/b and Abcg2 to form a robust cooperative drug efflux system. PMID: 23461902
30. Transintestinal cholesterol excretion is regulated by PCSK9/ABCB1/statins. PMID: 23559630
31. P-glycoprotein (Mdr1a/1b) and breast cancer resistance protein (Bcrp) decrease the uptake of hydrophobic alkyl triphenylphosphonium cations by the brain. PMID: 23454352
32. Results indicate that the potency and specificity of sildenafil as an inhibitor of ABCB1 and ABCG2 is not sufficient to warrant further clinical testing of this agent in combination with anticancer drugs. PMID: 23422148
33. Functional regulation of P-glycoprotein at the blood-brain barrier in proton-coupled folate transporter (PCFT) mutant mice. PMID: 23212123
34. the functioning of ABCB1 as an efflux pump does not depend on actin, which is due to its distribution in both cell surface-localized non-raft membrane areas and lipid raft domains PMID: 23085402
35. Absence of P-glycoprotein (Pgp) transport of antiepileptic drug mephobarbital at the blood-brain barrier is confirmed in vitro by concentration equilibrium transport assay in cell lines transfected with MDR1. PMID: 22342565
36. Sodium nitroprusside pretreatment functionally impairs P-gp in the in vitro blood-brain barrier model. PMID: 22864744
37. Hyperglycemia induced reactive oxygen species and activated PKC in MDCK-II cells, leading to the decrease in P-glycoprotein expression PMID: 22721613
38. The intracellular accumulation of vemurafenib is significantly restricted because of active efflux by P-gp(ABCB1)and BCRP. PMID: 22454535
39. Pharmacokinetics of quinacrine efflux from mouse brain via the P-glycoprotein efflux transporter. PMID: 22768295
40. the effects of P-gp on intestinal injury and repair PMID: 22780103
41. Both P-gp and Bcrp1 reduce the brain penetration of erlotinib. PMID: 20963470
42. Data indicate that mdr1ab(-/-) P-glycoprotein (Pgp)-deficient mice showed excess weight, hypertrophy of adipose mass, high insulin and glucose levels in plasma. PMID: 21949682
43. Data show that NSC73306 demonstrated MDR1-selectivity against all P-gp-expressing cell lines examined. PMID: 21721528
44. ABCB1 identifies a subpopulation of uveal melanoma cells with high metastatic propensity PMID: 21575142
45. results give evidence for a functional role of transport mechanisms at the blood-brain barrier, specifically of P-gp, and its subregional distribution. PMID: 21304228
46. Results suggest that Mdr1a/b plays a role in irinotecan and SN-38 elimination. PMID: 20583968
47. P-gp affected oral absorption and brain penetration of tandutinib to a greater extent than Bcrp, but Bcrp contribution to systemic clearance of tandutinib was greater than P-gp. PMID: 20670210
48. The average brain-to-plasma concentration ratio and blood-brain barrier partitioning of levosulpiride were 2.3- and 2.0-fold higher in Abcb1a/1b(-/-) mice than in wild-type mice, respectively. PMID: 20438811
49. Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation PMID: 20103600
50. A single application of mdr1b/1a siRNA followed by treatment with conventionally used cytostatics resulted in more than threefold decrease in lymphosarcoma tumor size as compared with the control animals. PMID: 20470373

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KEGG: mmu:18669

STRING: 10090.ENSMUSP00000009058

UniGene: Mm.146649