Recombinant Mouse Neuronal acetylcholine receptor subunit alpha-4 (Chrna4), partial

1. Data suggest that receptor complex assembly from Chrna4 and Chrnb2 on neuronal cell surface is up-regulated by nicotine; combined effects of increased assembly stoichiometry and preferential trafficking likely drive up-regulation of this receptor complex on neuronal cell surface upon nicotine exposure. (Chrna4 = a4 nicotinic receptor; Chrnb2 = b2 nicotinic receptor) PMID: 29074617
2. Results suggest that alpha4beta2( *) nAChRs can produce sustained regulation of inhibitory post-synaptic GABA currents, in fast-spiking layer V neurons of the mouse frontal area 2. PMID: 27793780
3. Mice lacking alpha4 subunits in ventral midbrain consumed significantly more nicotine at the highest offered nicotine concentration compared to control mice. PMID: 28759616
4. Varenicline treatment may prevent scopolamine-induced memory disturbance by a molecular mechanism that may involve increased alpha4beta2 nAChR availability. Varenicline dose-dependently increased protein expression of both the alpha4 and beta2 subunit in cell cultures and brain tissues, respectively, but had no effect on mRNA expression; lack of change in mRNA expression suggests a still unknown post-transcriptional me... PMID: 27012889
5. Results demonstrate that high-affinity alpha4beta2 nicotinic acetylcholine receptors are necessary for the effects of acute nicotine on contextual fear extinction. PMID: 26688111
6. Data show alpha4 subunit role in conferring potentiation by 17beta-estradiol (BEST) and indicate that the C-terminal region is involved in both binding of betaEST and potentiation, while the N-terminal domain seems involved in enhancing its efficacy. PMID: 26684647
7. The alpha4 nAChR subunit is regulated by protein kinase C epsilon phosphorylation. PMID: 26103136
8. neuroinflammation is sufficient to provoke the decrease of a7 and a4b2 nAChRs, Ab42 accumulation and memory impairment in mice and a7(1-208) nAChR-specific antibodies can cause inflammation of the brain with symptoms typical for Alzheimer disease. PMID: 25816313
9. Lynx2 and Ly6g6e have roles in intracellular trafficking and allosteric potentiation of alpha4beta2 nAChRs, respectively PMID: 26276394
10. cotinine alters the assembly and trafficking of alpha4beta2 nicotinic acetylcholine receptors PMID: 26269589
11. The study shows that nAChR alpha4 beta2 sensitizes a MAPK-linked toxicity pathway on prolonged exposure to ABETA (1-42). PMID: 26139609
12. This study has revealed complex effects of Chrna4 deficiency and prenatal nicotine exposure on ventilatory and metabolic interactions and responses to stress. PMID: 25596543
13. It indicated that Correlation between nAChalpha4-, 5-HT1A- and 5-HT7-containing receptors and latencies on day 16 may point to a probable link in extinction mechanisms. PMID: 24837029
14. These results question the conclusion that a dominant-negative mechanism would explain the dominance of the mutant L501fsX533 Fz4 allele in the transmission of a form of Familial exudative vitreoretinopathy. PMID: 25086772
15. Study demonstrates that chronic pre-exposure to nicotine at a dosing regimen that results in maximal alpha4 nAChR upregulation results in significantly elevated oral nicotine self-administration in a two-bottle choice paradigm in mice PMID: 25038610
16. Lynx1 has a role in shifting alpha4beta2 nicotinic receptor subunit stoichiometry by affecting assembly in the endoplasmic reticulum PMID: 25193667
17. these data indicate that a4-nAChR have an impact on motor output. PMID: 23688922
18. Cerebral cortex alpha4 nAChR subunits increased in rats given nicotine or varenicline, but subunits from rats given saline or saz-A during the phase 2 treatment were not significantly different from all-phase saline controls. PMID: 24422997
19. a new mechanism of alpha4 nAChR signaling and immune regulation in T cells, possibly accounting for the effect of smoking on the immune system. PMID: 24107512
20. In this study, alpha4 and alpha7 nicotinic acetylcholinesterase receptors all modulated dopamine-induced abnormal involuntary movements. PMID: 23831952
21. By stimulating alpha4beta2-nicotinic acetylcholine receptors in the prefrontal cortex, working memory deficits are alleviated in aged mice. PMID: 23352115
22. alpha4 nAChRs serve as sensors for ethanol-induced oxidant stress in lung fibroblasts. PMID: 23421903
23. Data indicate that functional alpha4/beta2 nicotinic acetylcholine receptors (alpha4beta2 nAChR) plays a role in proliferation and differentiation fate into a neuronal lineage in neural progenitors of developing neocortex. PMID: 23056257
24. Stimulation of alpha4-nAChR and alpha7-nAChR by nicotine may lead to a significant increase in the rate of mouse induced pluripotent stem cell proliferation. PMID: 22483693
25. determined the site specificity for Mor potentiation by studying differences in modulation between alpha3beta2 and alpha4beta2 receptors PMID: 22064677
26. alpha4* nAChR subunits have a new role in regulating rapid changes in functional responsiveness of the adult somatosensory cortex. PMID: 22279206
27. In the acute MPTP model of Parkinson's disease, time-courses of altered expression for nAChR alpha7, alpha4 and beta2 subunits closely mirrored the deficits observed in animal motor activity PMID: 21406211
28. propose that in the P3 superior cervical ganglion of wild type mice, alpha3beta4 (+/-alpha5) represent about 62% of receptors, whereas 17% are alpha3beta2beta4, and 21% are alpha4beta2 (+/-alpha5) receptors PMID: 21485013
29. Nicotinic acetylcholine receptors containing the alpha4 subunit are critical for the nicotine-induced reduction of acute voluntary ethanol consumption PMID: 21239887
30. The alpha4 subunit, but not the alpha6 subunit, is necessary for ICSA and nicotine-induced bursting of VTA DAergic neurons, whereas subunits alpha4 and alpha6 together regulate the activity dependence of dopamine transmission in the nucleus accumbens. PMID: 21502501
31. This study indicated that activation of alpha4* nAChRs is necessary and sufficient for varenicline reduction of alcohol consumption. PMID: 20668200
32. Compared with Chrna4 T529 littermate controls, the Chrna4 A529 knock-in mice exhibited greater sensitivity to the hypothermic effects of nicotine, reduced oral nicotine consumption and did not develop conditioned place preference to nicotine. PMID: 20061993
33. a D(2)R-alpha4*-nAChR functional interaction regulates cholinergic interneuron activity PMID: 19720621
34. Results show that lynx1 promotes the largest of three current amplitudes elicited by ACh through alpha(4)beta(2) nAChRs and that lynx1 enhances receptor desensitization. PMID: 11906696
35. Results suggest that disruption of balanced cholinergic transmission by constitutive overexpression of acetylcholinesterase is accompanied by variable upregulation of nicotinic receptor subtypes alpha4, alpha 7, and beta 2. PMID: 12059039
36. A polymorphism in the mouse neuronal alpha4 nicotinic receptor subunit results in an alteration in receptor function. PMID: 12130686
37. functional nicotinic ACh receptors on stem and progenitor cells of fetal mouse cerebral cortex as early as embryonic day 10 PMID: 12438103
38. These studies demonstrate that intact alpha 4 nAChR subunits provide significant in vivo protection against the proconvulsant effects of GABA antagonism. PMID: 12623222
39. Alpha4 nicotinic receptor knock-in mice have increased sensitivity to agonist-induced seizures, straub tail, and hippocampal theta rhythm. PMID: 12684443
40. This study results indicate that alpha4-containing nAChRs exert a tonic control on striatal basal dopamine release, which is mediated by a heterogeneous population of nAChRs. PMID: 12713636
41. results suggest that the A/T polymorphism influences the initial sensitivity of the alpha4 nicotinic receptor to ethanol PMID: 12766617
42. The polymorphism in the mouse alpha4 subunit of Chrna4 is located in a previously unidentified functional domain of the receptor subunit that influences receptor function, including regulation of the affinity of alpha 4 beta 2 receptors. PMID: 12871652
43. In different strains of mice, polymorphisms in nAChRalpha4 did not clearly correlate with strain-related differences in cell type-specific nAChR expression. PMID: 14681929
44. data indicate that activation of a4* receptors is sufficient for nicotine-induced reward, tolerance, and sensitization PMID: 15528443
45. nAChR immunoreactivity is present in genioglossal motoneurons and suggest a role for alpha-4 subunits containing nAChRs in the regulation of upper airway patency. PMID: 15705531
46. Results suggest that that the up-regulation of alpha4-nicotinic acetylcholine receptor may make cortical neurons more sensitive to the neuroprotective action of donepezil and galanthamine. PMID: 16313899
47. Hypersensitive alpha4* nicotinic receptors in mice mediate changes in the sleep-wake cycle. PMID: 16339034
48. An inducible genetic model for degeneration of midbrain dopaminergic neurons in adults, using nAChR subunit 4 transgenic mice, is presented. PMID: 16675851
49. Together, these results show that immunolabeling is applicable to reliable, quantitative investigations of neuronal nAChRs, and that subunit-null mutants can be appropriate controls for such experiments. PMID: 17072836
50. discussion of the role of variability in the genes that encode the two major brain-expressed alpha subunits, alpha4 and alpha7, in modulating behavior, physiology and disease risk in both humans and mice [review] PMID: 17981562

Show More

Hide All

KEGG: mmu:11438

STRING: 10090.ENSMUSP00000066338

UniGene: Mm.252369