Product Details

Purity

>85% (SDS-PAGE)

Target Names

Nrcam

Uniprot No.

Q810U4

Alternative Names

Nrcam; Kiaa0343; Neuronal cell adhesion molecule; Nr-CAM; Neuronal surface protein Bravo; mBravo; NgCAM-related cell adhesion molecule; Ng-CAM-related

Species

Mus musculus (Mouse)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.

Gene References into Functions

NrCAM is expressed by several neural and sensory epithelial subtypes within the developing cochlea, and the loss of Nrcam confers numerous, but nonpermanent, developmental defects in innervation and sensory domain patterning. PMID: 29536590
This study demonistrated that Neural cell adhesion molecule NrCAM regulates Semaphorin 3F-induced dendritic spine remodeling in mice. PMID: 25143608
The results demonstrate that NrCAM contributes to mediolateral retinocollicular axon targeting by regulating RGC branch orientation through a likely mechanism in which ephrinB/EphB phosphorylates NrCAM to modulate linkage to the actin cytoskeleton. PMID: 24023801
NrCAM is required for normal maturation of cortical visual acuity. The aberrant projection of thalamic motor and somatosensory axons to the visual cortex in NrCAM-null mutant mice impairs cortical functions. PMID: 21273439
These results provide evidence that NRCAM mediates domains of function relevant to symptoms observed in autism. PMID: 19540269
Expression of Nr-CAM becomes strictly confined to Purkinje and Golgi cells in postnatal cerebellum, suggesting a possible role for the maturation or stabilization of synaptic contacts between climbing fibers and Purkinje cells. PMID: 12182881
induction of Nr-CAM transcription plays a role in melanoma and colon cancer tumorigenesis PMID: 12183361
these observations support NrCAM as a positionally cloned and drug-regulated gene whose variants are likely to change expression and alter substance abuse vulnerabilities PMID: 16123759
Over-expression of the Nr-CAM ectodomain is associated with cell transformation and tumorigenesis in mice PMID: 16357171
Nrcam affects axonal guidance and the anatomy of the ventricular system and the cerebellar vermis but act differently on these processes. PMID: 18588951
Two point mutations are responsible for the severe peripheral neuropathy phenotype: a partial loss-of-function mutation in the gene for phosphatidate phosphatase Lpin1 and a truncation mutation in the gene that encodes NrCAM. PMID: 19793967

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Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Secreted.

Protein Families

Immunoglobulin superfamily, L1/neurofascin/NgCAM family

Tissue Specificity

Detected in sciatic nerve. Detected in brain, especially in the cerebellum Purkinje cell layer, inner granule cell layer and molecular layer (at protein level). Detected in neurons and Schwann cells.

Database Links

KEGG: mmu:319504

STRING: 10090.ENSMUSP00000020939

UniGene: Mm.208439

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Recombinant Mouse Neuronal cell adhesion molecule (Nrcam), partial

Product Details

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Target Background

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