Recombinant Mouse Nuclear receptor subfamily 4 group A member 3 (Nr4a3)

1. NOR1 deletion induced differential inflammatory gene transcription in macrophages but did not influence abdominal aortic aneurysm formation. PMID: 29047330
2. Nor-1 expression drives multiple physiological changes/pathways that are critical to the beneficial responses of muscle to exercise. PMID: 27144290
3. these results show that NR4A3 is involved in TLR-mediated activation and gene expression of dendritic cells PMID: 28893954
4. Study shows that NOR-1 can transduce survival signals in neuronal cells responsible for hypoxiainduced apoptotic insults through activation of a CREB/cIAP2-dependent mechanism PMID: 26613168
5. Nuclear receptors of the NR4a family are not required for the development and function of follicular T helper cells PMID: 25899083
6. Promoting Liver X receptor-alpha expression inhibits lipopolysaccharide induced inflammation in Kupffer cells through elevating NOR-1 expression. PMID: 26239564
7. Identified Nur77/Nor1 as novel regulators of thrombomodulin expression and function in vascular endothelial cells. PMID: 26634653
8. Nr4a3 factor plays crucial role regulatory T cells, mediating the two defining characteristics of regulatory T cells: stability of cell lineage and immunosuppressive functions. PMID: 26304965
9. Studies demonstrate that NOR1 deletion in hematopoietic stem cells accelerates atherosclerosis formation by promoting myelopoiesis in the stem cell compartment and by inducing local proatherogenic activities in the macrophage. PMID: 24806827
10. Our data support a role for NOR-1 as a negative modulator of the acute response elicited by pro-inflammatory stimuli in the vasculature. PMID: 25536180
11. Results indicate that DNA hypomethylation of the CpG island at Nr4a3 exon 3 is associated with low Nr4a3 expression, and correlates with poor prognosis of neuroblastoma. PMID: 24626568
12. Skeletal muscle-specific Nor-1 expression regulates genes and pathways that regulate adiposity, muscle fiber type metabolic capacity, and endurance. PMID: 24065705
13. NR4A nuclear receptors are involved in negative selection of thymocytes, Treg differentiation and the development of Ly6C monocytes. Nur77 and Nurr1 attenuate atherosclerosis in mice whereas NOR-1 aggravates vascular lesion formation. PMID: 24005216
14. Results indicate mutual antagonism between neuron-derived orphan receptor 1 (NOR1) and glucocorticoid receptor (GR) to be a key rheostat for peripheral metabolic signals to centrally control energy balance. PMID: 23897430
15. Over-expression of neuron-derived orphan receptor-1 (NOR-1) exacerbates neointimal hyperplasia after vascular injury PMID: 23390133
16. Insulin-mediated AKT phosphorylation was increased by NR4A3 hyperexpression and decreased following shRNA NR4A3 suppression. PMID: 23104421
17. In mice, the orphan nuclear receptor Nor-1 activates proliferation of quiescent hepatocytes and is required for hepatocyte proliferation after partial hepatectomy. PMID: 23462179
18. results suggest that Nr4a receptors have key roles in determining CD4(+) T cell fates in the thymus and thus contribute to immune homeostasis PMID: 23334790
19. Nor-1 expression in skeletal muscle significantly improved glucose tolerance, oxygen consumption, and endurance/fatigue resistance, consistent with the acquisition of a more oxidative muscle phenotype. PMID: 22282471
20. Promoting the expression of LXR alpha in Kupffer cells can elevate NOR-1 expression and inhibit the inflammatory reaction. PMID: 22152248
21. NOR1 transactivates the Skp2 promoter through a nerve growth factor-induced clone B response element (NBRE). PMID: 21868379
22. In response to purified LPS, strong upregulation of Nr4a3, but not of Nr4a1 or Nr4a2 was seen in mast cells PMID: 21621845
23. Brain region-specific changes in glucocorticoid expression are strain dependent and contribute to depressive behavior in a Bax-deficient mouse model. PMID: 20851110
24. Data show that NOR1 and LXRalpha were highly induced at mRNA and protein levels in dendritic cells upon infection with Newcastle Disease virus (NDV) or murine cytomegalovirus (MCMV). PMID: 21492741
25. Reduced gene dosage of NR4A1 and NR4A3 in hypoallelic (NR4A1(+/-)NR4A3(-/-) or NR4A1(-/-)NR4A3(+/-)) mice below a critical threshold leads to a chronic myeloid malignancy. PMID: 21205929
26. data describe a new role for LXR to regulate NOR-1 gene expression in adipocytes and demonstrate that these two nuclear receptors have an interdependent regulatory relationship, in addition to each being involved in the control of metabolic fuel usage. PMID: 19238156
27. The orphan receptor Nor1 is involved in TCR-mediated cell death and thymocyte-negative selection. PMID: 12223510
28. the NR4A subgroup mediates the genotoxic stress response PMID: 12709428
29. Nor-1-deficient embryos fail to complete gastrulation and display abnormal expression of a number of early developmental markers and defects in growth or distribution of emerging mesoderm cells PMID: 13129926
30. Ddata indicate that nor-1 plays a critical role in neuronal survival and axonal guidance in the developing murine hippocampus and that hippocampal dysgenesis in nor-1-/- mice may be an underlying cause of seizure susceptibility. PMID: 15456880
31. a second ERK-dependent pathway, independent of MSK and CREB, was also required for the transcription of Nurr1 and Nor1 PMID: 15910281
32. The in vivo induction of the NR4A family members by PTH suggests their involvement in, at least some, PTH-induced changes in bone metabolism. PMID: 15910753
33. NR4A nuclear receptors NR4A1, NR4A2, NR4A3 are potential transcriptional mediators of inflammatory signals in activated macrophages PMID: 15964844
34. prostaglandin A2 can serve as a transactivator of NOR1 PMID: 16141523
35. Simultaneous deletion of Nr4a3 and Nr4a1 results in acute myeloid leukemia. PMID: 17515897
36. FGF-8b induces the expression of Nor1 orphan nuclear receptors that are involved in mediating the growth promoting effect of FGF-8b in osteoblasts. PMID: 18809462
37. Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1. PMID: 18945812
38. Blockade of MINOR expression dramatically decreases apoptosis in dendritic cells and enhance cancer vaccine efficacy. PMID: 19164597
39. The significant induction (between 1 and 4h) of the NR4A genes in multiple tissues, was identified. PMID: 19465082
40. These findings suggest that 5-HT2C receptor-independent proopiomelanocortin-derived peptides regulate the expression of hypothalamic NOR1, which is a novel modulator of feeding behavior and energy balance. PMID: 19523439

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KEGG: mmu:18124

STRING: 10090.ENSMUSP00000030025

UniGene: Mm.247261