Recombinant Mouse POU domain, class 4, transcription factor 1 (Pou4f1)

1. This study showed that three genes were found to be consistently regulated by Brn3a throughout postnatal retina development - Mapk10, Tusc5 and Cdh4. PMID: 29958540
2. Double morphant embryos targeted with morpholino oligonucleotides to both TFs develop significant cardiac defects (looping abnormalities and valve defects) suggesting essential roles for Brn-3a and Brn-3b in developing hearts. PMID: 28594399
3. Pou4f1 and pou4f2 are dispensable for the long-term survival of adult retinal ganglion cells in mice. PMID: 24736625
4. The deficiency of Pou4f1 who perform poorly in motivation-based locomotor behaviors, such as voluntary wheel running and the accelerating rotarod, but show only minor abnormalities in gait and balance and exhibit normal levels of basal locomotion. PMID: 25143617
5. Data indicate that Brn3 transcription factors Brn3b affects Brn3a and Brn3c positive Retinal Ganglion Cells (RGCs) in cell autonomous and non-cell autonomous fashion. PMID: 24116103
6. The results demonstrated a critical role for Brn3a in generating dorsal root ganglia sensory neuron diversity and regulating sensory afferent projections to the central targets. PMID: 22326227
7. neither Brn3a nor Brn3c are expressed in intrinsically photosensitive retinal ganglion cells PMID: 21935940
8. Brn3 gene expression patterns in the retina and inner ear, these experiments suggest a deep functional similarity among primary somatosensory neurons, spiral and vestibular ganglion neurons, and retinal ganglion cells PMID: 22262898
9. Progressive increase in IOP and loss of Brn3a signals in D2 animals were consistent with glaucoma progression starting after 6 months of age. PMID: 21757588
10. data define AR as a direct Brn-3a interactor and verify a simple interacting protein prediction methodology that is likely to be useful for many other proteins PMID: 20228055
11. Data show that Brn3a acts upstream of the Runx factors, which then repress TrkB expression to allow establishment of the non-overlapping Trk receptor profiles and correct terminally differentiated phenotypes. PMID: 20096094
12. Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion. PMID: 19877281
13. Deficiency of Brn-3a may cause the increase and decrease of Cgrp-immunoreactive expression in small dorsal root ganglion (DRG) neurons projecting to the dorsal column and large DRG neurons projecting to the deep dorsal horn, respectively. PMID: 11930150
14. Nociceptors and low-threshold mechanoreceptors with medium-sized to large cell bodies in the trigeminal ganglion may be sensitive to the loss of Brn-3a. PMID: 12225879
15. Brn3a locus functions as a self-regulating unit to maintain a constant expression level of this key regulator of neural development.Sensory expression of Brn3a is regulated by a specific enhancer, Brn3a binds to conserved sites within this enhancer PMID: 12441296
16. Axon growth is markedly disturbed in Brn3a knockout mice; it is unlikely that Brn3a targets Bcl-2 or mediates the defects in axon guidance and neuronal survival observed in the sensory ganglia of Brn3a knockout mice. PMID: 12598723
17. in Brn-3a gene two functions are separately controlled with an N-terminal domain being essential for neuronal survival, whereas the POU domain is essential for neurite outgrowth. PMID: 15194866
18. Regulatory role in trigeminal ganglion growth conserved in more posterior sensory ganglia but not in CNS neurons. PMID: 15253936
19. Hsp27 expression and cell survival are regulated by the POU transcription factor Brn3a PMID: 15272315
20. HIPK2, through regulation of Brn3a-dependent gene expression, is a critical component in the transcriptional machinery that controls sensory neuron survival PMID: 15492043
21. Interaction with Brn-3a in sensory neurons may be critical for modulating p53-mediated gene expression and hence cell fate. PMID: 15532030
22. a crucial role for Brn-3a in determining the pathway taken by p53 when co-expressed during development and thus in controlling the fate of these cells. PMID: 15598651
23. The present study suggests that Brn-3a may normally suppress TH expression in many small DRG neurons but activate TH expression in large DRG neurons. PMID: 15725417
24. Brn-3a is required for the generation of proprioceptors in the mesencephalic trigeminal tract nucleus. PMID: 16040009
25. Brn3a is expressed in retinal ganglion cells innervating the principal retinothalamic/retinocollicular pathway mediating cortical vision. PMID: 16354917
26. expression of the developmental regulator FGF10 is approximately 35-fold increased in the developing trigeminal ganglia of Brn3a-null mice PMID: 16838370
27. Site occupancy by Brn3a can be correlated with evolutionary conservation of the genomic regions containing the recognition sites and also with histone modifications. PMID: 17196582
28. Brn3a represses differences in gene expression between sensory neurons generated at different axial levels, and regulates developmental gene expression; functionally similar populations of neurons are generated from different embryological substrates. PMID: 17239249
29. Data suggest that Brn-3a and b POU factors may play an important role in the development and maintenance of critical cell types and structures within the heart, in part via developmental regulation of myocardial Hsp27 expression. PMID: 18368538
30. results suggest that co-factors binding to p73 C terminus facilitate activation on Bax but not p21 CIP1/Waf1 promoter and that Brn-3a modulates this interaction PMID: 18421303
31. Data show that Pou4f1 is regionally enriched in the Brainstem (Pons and Medulla) of mouse brain. PMID: 18625066
32. Brn-3a deficiency affects the number and cell size of CGRP- and calcium-binding protein-containing neurons. PMID: 19288186
33. Loss of Brn3a leads to an increase in the ratio of bistratified to monostratified RGCs, with only modest RGC loss and little effect on central projections. PMID: 19323995

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KEGG: mmu:18996

STRING: 10090.ENSMUSP00000060798

UniGene: Mm.246550