Recombinant Mouse Podocin (Nphs2), partial

1. While R140Q podocin mRNA expression was elevated, protein abundance was reduced by more than 50% within one week following induction PMID: 29049388
2. ATP evokes activation of TRPC6 channels in podocytes through P2Y receptors, podocin, and generation of reactive oxygen species. PMID: 24553432
3. the carboxyl terminus of podocin/MEC-2 has to be placed at the inner leaflet of the plasma membrane to mediate cholesterol binding and contribute to ion channel activity. PMID: 24596097
4. Podocin is necessary for assembly of the NOX2-TRPC6 complex in lipid rafts. PMID: 23948707
5. study shows a variety of mechanical stimuli cause activation of endogenously expressed TRPC6 channels of podocytes; also that podocin reduces sensitivity of TRPC6 channels to mechanical stimuli, so that a loss of podocin function would result in hyperactivation of TRPC6 channels in foot processes PMID: 23657570
6. These data descrived the importance of concomitant decreases in podocin, CD2AP and tensin2 during septic acute renal failure-associated proteinuria. PMID: 21799297
7. we are for the first time able to prove the expression of a novel podocin isoform (isoform 2), exclusively and constitutively expressed in human podocytes, and reveal singular extrarenal podocin expression in human and murine testis PMID: 21499232
8. Data show that the main slit diaphragm proteins, nephrin and podocin, are affected from the earlier stages of lupus nephritis and their expression correlates with disease histology. PMID: 21478284
9. Coexpression of CIN85/Ruk(L) with CD2AP led to a decreased binding of CIN85/Ruk(L) to nephrin and podocin, which indicates a functional competition between CD2AP and CIN85/Ruk(L). PMID: 20457601
10. Nphs2-/- mice developed proteinuria during the antenatal period and died a few days after birth from renal failure caused by massive mesangial sclerosis. PMID: 14701729
11. The abnormality of a single podocyte molecule, caused by a single gene mutation in podocin can lead to hereditary nephrotic syndromes. PMID: 16501493
12. Results suggest that nephrin Y1193 serves as a molecular switch that determines the integrity of the slit diaphragm by functional competition between beta-arrestin2 and podocin. PMID: 16968782
13. MEC-2, Podocin, and probably many other PHB-domain proteins by binding to themselves, cholesterol, and target proteins regulate the formation and function of large protein-cholesterol supercomplexes in the plasma membrane PMID: 17079490
14. Mutations in the NPHS2 gene, encoding podocin, are responsible for familial autosomal recessive and sporadic cases of steroid-resistant nephrotic syndrome PMID: 18288100
15. Podocin inactivation in mature kidneys causes focal segmental glomerulosclerosis and nephrotic syndrome. PMID: 19713307

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KEGG: mmu:170484

STRING: 10090.ENSMUSP00000027896

UniGene: Mm.289099