Recombinant Mouse Potassium voltage-gated channel subfamily H member 1 (Kcnh1), partial

1. n this report, we present two independent screening campaigns in which we wanted to identify small molecules that bind to either the intracellular cytoplasmic amino terminal Per-Arnt-Sim (PAS) domain from the human EAG-related gene (ERG) channel or the amino or carboxy terminal globular domains from the mouse EAG1 channel, affecting their interaction. PMID: 26975997
2. KV10.1 localizes to the centrosome and the primary cilium and promotes ciliary disassembly. Interference with KV10.1 ciliary localization abolishes not only the effects on ciliary disassembly, but also KV10.1-induced tumor progression in vivo Conversely. PMID: 27113750
3. Expression of Kv10.1 driven by phosphorylated Rb/E2F1 contributes to G2/M progression of cancer and non-transformed cells. PMID: 27029528
4. KV 10.1 opposes activity-dependent increase in calcium influx into the presynaptic terminal of the parallel fibre-Purkinje cell synapse PMID: 25556795
5. deletion of Kv10.1 does not show a marked phenotype is a prerequisite for utilizing Kv10.1 blocking and/or reduction techniques, such as siRNA, to treat cancer. PMID: 23424202
6. The flavonoids identified here potentiated EAG1 channels by binding to the CNBHD. PMID: 23440277
7. 2 A resolution crystal structure of the eag domain-CNBHD complex of the mouse EAG1 (also known as KCNH1) channel PMID: 23975098
8. Biochemical evidence was provided that suggests that there is also an unliganded conformation where the C-terminus of the domain peels away from its bound position. A role was shown for the cyclic nucleotide-homology domain in channel gating. PMID: 22732247
9. X-ray diffraction of EAG channel data were collected to 2.2 A resolution and the crystal belonged to the hexagonal space group P3(1)21 PMID: 22442238
10. K(V)10.1 channels at the nuclear envelope might participate in the homeostasis of nuclear K(+), or indirectly interact with heterochromatin, both factors known to affect gene expression PMID: 21559285
11. Single crystal of EAG PAS from Mus musculus belonging to space group P3221 PMID: 20823525
12. Ether-a-go-go-related gene K channels in interstitial cells of Cajal contribute to membrane potential and play role in regulation of pacemaker activity of small intestine. PMID: 12958021
13. Eag1 interferes with the cellular mechanism for maintaining oxygen homeostasis, increasing HIF-1 activity, and thereby VEGF secretion and tumor vascularization PMID: 18927085
14. Results indicate that cyclic nucleotides do not directly modulate mEAG1 and hERG1 channels. PMID: 19671703
15. Both M-eag and its C. elegans homolog egl-2 are inhibited by the tricyclic antidepressant imipramine. PMID: 10559392

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KEGG: mmu:16510

STRING: 10090.ENSMUSP00000077563

UniGene: Mm.4489