Recombinant Mouse Ras-specific guanine nucleotide-releasing factor 2(Rasgrf2) ,partial

Code CSB-YP019361MO
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Source Yeast
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Code CSB-EP019361MO
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Source E.coli
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Code CSB-EP019361MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP019361MO
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Source Baculovirus
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Code CSB-MP019361MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Rasgrf2
Uniprot No. P70392
Alternative Names Rasgrf2; Grf2; Ras-specific guanine nucleotide-releasing factor 2; Ras-GRF2; Ras guanine nucleotide exchange factor 2
Species Mus musculus (Mouse)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation.
Gene References into Functions
  1. Nuclear migration in retinal cone photoreceptors is altered in GRF2 knockout mice. PMID: 26743081
  2. adaptations in the noradrenergic system contribute to the Rasgrf2 enhanced risk of alcoholism. PMID: 24737505
  3. Findings indicate that GRF2 regulates both the basal level and environmentally induced increase of newborn neuron survival, as well as in the induction of a distinct form of synaptic plasticity of newborn neurons that contributes to learning and memory PMID: 24894950
  4. These data suggest that Rasgrf2 controls dopaminergic signalling and adaptations to alcohol also in other brain regions, beyond the nucleus accumbens. PMID: 25454123
  5. these results suggest that betaarrestin1 regulates rasgrf2 gene expression and Rac activation to affect membrane protrusion and cell migration and invasion. PMID: 24692549
  6. RASGRF2 has a role in the regulation of mesolimbic dopamine neuron activity, reward response, and alcohol use and abuse PMID: 23223532
  7. Study demonstrates that NR2A-, but not NR2B, containing NMDA receptors induce LTP in pyramidal neurons of the CA1 hippocampus from 1 month old mice through Ras-GRF2 and Erk. PMID: 20661302
  8. These data reveal unexpected negative roles for Vav1 and RasGRF2 in different stages of T-cell lymphoma progression. PMID: 20011522
  9. Mediates forms of synaptic plasticity by coupling different classes of NMDA receptors to distinct MAP kinase pathways PMID: 16467520
  10. These results identify RasGRF2 as an additional component of the signaling machinery involved in T-cell receptor- and NF-AT-mediated immune responses. PMID: 17923690

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Subcellular Location Cytoplasm, Cell membrane, Peripheral membrane protein, Endoplasmic reticulum membrane, Peripheral membrane protein
Tissue Specificity Expressed in brain in the nucleus of the solitary tract. Not observed in the hippocampus (at protein level).
Database Links

KEGG: mmu:19418

UniGene: Mm.248630

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