Recombinant Mouse Resistin-like beta (Retnlb)

1. promotes host-bacterial mutualism by regulating the spatial segregation between the microbiota and the intestinal epithelium PMID: 28973871
2. The goblet cell-derived RELM-beta drives spontaneous colitis in Muc2-deficient mice by promoting commensal microbial dysbiosis. PMID: 26813339
3. lack of RELMbeta leads to increased colonic expression of T helper cell type-2 cytokines and IL-17, associated with a reduced ability to maintain intestinal homeostasis PMID: 27397737
4. These data suggest the contribution of increases in RELMbeta in the gut and Kupffer cells to NASH development, raising the possibility of RELMbeta being a novel therapeutic target for NASH. PMID: 26818807
5. RELMbeta protein levels were upregulated in Angiotensin II-induced Abdominal aortic aneurysm mice.Immunohistochemical staining revealed abundant expression of RELMbeta in AAA group, with scarce expression with saline treatment animals. PMID: 25479529
6. findings demonstrate that RELM-beta and goblet cells play an unexpected, yet critical role in recruiting CD4+ T cells to the colon to protect against an enteric pathogen PMID: 26285214
7. elevated RELM-beta expression in asthmatic airways contributes to airways remodelling at least partly by increasing fibroblast proliferation and differentiation with resulting deposition of extracellular matrix proteins. PMID: 25545115
8. RELMbeta is abundantly expressed in foam cells within plaques and contributes to atherosclerosis development via lipid accumulation and inflammatory facilitation. PMID: 23702657
9. a novel role for GC-C signaling in facilitating mucosal wounding and inflammation, and further suggest that this may be mediated, in part, through control of RELMbeta production PMID: 21555532
10. FIZZ2 is a T helper type (Th)2-associated multifunctional mediator with potentially important roles in the pathogenesis of fibrotic lung diseases. PMID: 21602491
11. Secretion of RELMbeta is dramatically reduced in germ-free mice. Furthermore, introduction of germ-free mice into a conventional environment results in enhanced expression and robust secretion of RELMbeta within 48 hours. PMID: 14598255
12. crystal structure reveals hexameric assemblies consisting of trimers linked to form hexamers through highly exposed disulfide bonds; structure suggests possible regulation through disulfide cleavage or by regulation during assembly PMID: 15155948
13. intestinal goblet cell-derived RELMbeta may be a novel Th2 cytokine-induced immune-effector molecule in resistance to Gastrointestinal nematode infection PMID: 15340149
14. Serum concentrations of RELMbeta and RELMgamma may be a novel intestinal-tract-mediating regulator of insulin sensitivity, possibly involved in insulin resistance induced by obesity and a high-fat diet PMID: 15834545
15. increased expression of RELMbeta may be involved in the pathogenesis of glucose intolerance and hyperlipidemia in some insulin-resistant models PMID: 16243841
16. model whereby the loss of epithelial barrier function by dextran sodium sulfate results in the activation of the innate mucosal response by RELMbeta located in the lumen PMID: 17024245
17. RELM-beta is a Th2-associated cytokine with potent inflammatory and remodeling activity PMID: 17545488
18. Insulin and TNFalpha as well as stearic acid, upregulated RELMbeta expression, while d-glucose downregulated RELMbeta PMID: 17936398
19. RELMbeta is involved in the initiation of ileitis in SAMP1/Fc mice and may act through the induction of proinflammatory cytokines from resident immune cells within the mucosa. PMID: 17982092
20. Goblet cell-macrophage cross-talk, mediated in part by RELMbeta, can promote adaptive CD4-positive T cell responses and chronic inflammation following intestinal helminth infection. PMID: 18802073
21. Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection. PMID: 19995957

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KEGG: mmu:57263

STRING: 10090.ENSMUSP00000023328

UniGene: Mm.21123