Recombinant Mouse T-box transcription factor TBX1 (Tbx1)

1. differences in gene expression profile within the secondary palate of wild type and mutant embryos is consistent with a primary role for Tbx1 during palatogenesis PMID: 29866044
2. the testis-expressed transcription factor, Tbx1, and the piRNA regulator of gamete development, Piwil1, were both found to be targeted for translational repression by MSI2. PMID: 28884822
3. A mutation in T-box of TBX1 was identified in an animal model of DiGeorge Syndrome; it's the DNA binding domain for transcription activity. PMID: 28105375
4. Data show that beta-catenin was increased in expression when Tbx1 was inactivated, suggesting that there may be a negative feedback loop between canonical Wnt and Tbx1. PMID: 28346476
5. Results show that loss of Tbx1 disrupts corticogenesis in mice by promoting premature neuronal differentiation in the medio-lateral embryonic cortex, which gives rise to the somatosensory cortex; altered polarity in both radially migrating excitatory neurons and tangentially migrating inhibitory interneurons; mesoderm-specific inactivation of Tbx1 is sufficient to recapitulate the brain phenotype PMID: 27005988
6. Tbx1 is required for the patterning but not timing of CA stem development and a Tbx1 reporter allele is expressed in myocardium adjacent to the left but not right CA stem. PMID: 26708418
7. Cell orientation is biased towards the shelf distal edge in the mid-palate of wild-type embryos but is essentially random in the Tbx1(-/-) mutant shelves PMID: 26689739
8. These results suggest that TBX1 plays a role in maintaining a progenitor state in VEGFR2+ cells. PMID: 26382615
9. Tbx1 is required upstream of key myogenic genes needed for core mesoderm cell survival and fate, between E9.5 and E10.5, resulting in formation of the branchiomeric muscles. PMID: 24705356
10. Tbx1 binds to the miR-96 promoter and represses miR-96 expression. PMID: 25556186
11. Loss of Tbx1 in mouse (Tbx1(-/-)) results in skeletal abnormalities similar to those of cleidocranial dysplasia in humans. PMID: 25209980
12. these data suggest that the molecular pathogenesis of ventricular septal defectss in Moz germline mutant mice is due to loss of MOZ-dependant activation of mesodermal Tbx1 and Tbx5 expression. PMID: 25912687
13. the present studies establish new insights into molecular aspects of TBX1 binding to DNA. PMID: 24797903
14. Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo. PMID: 24821700
15. Tbx1 deletion from the pharyngeal endoderm is sufficient to cause caudal pharyngeal arch segmentation defects by FGF-independent effectors that remain to be identified. PMID: 24812002
16. The Tbx1 level is an important determinant of endodermal and mesodermal lineage differentiation during embryonic development. PMID: 24564535
17. TBX1 regulates epithelial polarity and dynamic basal filopodia in the second heart field. PMID: 25371366
18. Tbx1 is required for inflow as well as outflow tract morphogenesis by regulating the segregation and deployment of progenitor cells in the posterior second heart field. PMID: 25190705
19. Tbx1 gene modulates pharyngeal and cardiac development. PMID: 24356861
20. Tbx1 negatively regulates thymic epithelial cell growth and differentiation, and extinction of Tbx1 expression in 3rd pharyngeal pouch endoderm is a prerequisite for thymus organogenesis PMID: 25053428
21. Results show that TBX1 regulates brain angiogenesis through the DLL4/Notch1-VEGFR3 regulatory axis. PMID: 23945394
22. A possible neurogenic cause underlying velopharyngeal dysfunction in Tbx1 heterozygous mice was explored by determining the size of the nucleus ambiguus in Tbx1 heterozygous and wild type mice. No difference in organ volume of the nucleus was found. PMID: 23642587
23. Tbx1 acts upstream of Smad7 controlling vascular smooth muscle and extracellular matrix investment of the fourth arch artery. PMID: 23011393
24. Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium PMID: 23093675
25. The data reveal a molecular mechanism for a specific chromatin modification of the Tbx1 locus intersecting with an environmental determinant, modeling variability in DiGeorge syndrome. PMID: 22921202
26. Study identified 127 genes that were potentially transrepressed by Tbx1; results showed that Tbx1 potentially transrepresses the promoter activities of 2 of these genes, Ywhae and C1qbp via palindromic sequences, including 5'-CCACAG-3' and 5'-(C/G)TGTG(C/G)-3', harbored within the promoters. PMID: 22982415
27. Findings suggest that TBX1 functions as an essential component of a mechanism that protects the embryo against perturbations in RTK signaling that may lead to developmental defects characteristic of 22q11DS. PMID: 22674535
28. Tbx1 interferes with the Gata4--> Mef2c regulatory pathway. PMID: 22367967
29. Tbx1 regulates the balance between proliferation and differentiation of keratinocytes and is essential for palatal fusion and oral mucosal differentiation PMID: 22371266
30. Tbx1, a transcription factor of the T-box family, regulates Wnt5a expression. We found that Tbx1 targets the BAF chromatin remodeling complex to the Wnt5a gene and interacts with a histone monomethyltransferase PMID: 22438823
31. MicroRNA-182 regulates otocyst-derived cell differentiation and targets T-box1 gene PMID: 22381690
32. Loss of two of the Tbx1/Tbx2/Tbx3 genes results in severe pharyngeal hypoplasia and heart tube extension defects. PMID: 22116936
33. Endothelial neuropilin disruption in mice causes DiGeorge syndrome-like malformations via mechanisms distinct to those caused by loss of Tbx1 PMID: 22396765
34. this study provides a series of newly identified RA effector genes for inner ear development downstream of mesenchymal Tbx1 that may contribute to the inner ear phenotype observed in Tbx1 loss of function mouse models. PMID: 22275070
35. Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity PMID: 22164283
36. TBX1 acts as an intrinsic rheostat of BMP signalling: it is a gatekeeper that governs the transition between stem cell quiescence and proliferation in hair follicles PMID: 22495305
37. Tbx1 is a gene responsible for the phenotypes of 22q11.2 hemizygosity-associated autism spectrum disorder. PMID: 21908517
38. data show that ectopic expression of Tbx1 restored contact inhibition to the skin tumor cells, suggesting that this developmentally important transcription factor may have a novel dual role as a negative regulator of tumor growth PMID: 21438027
39. A conditional gene inactivation approach was applied to test the hypothesis that Bmp4 expressed from the Tbx1 expression domain plays a critical role for normal development of outflow tract and pharyngeal arch arteries. PMID: 21123999
40. Pharyngeal endoderm expression is regulated by an enhancer within the fragment TEBIn1, expression in the head mesoderm is regulated by the FG fragment, and TB11 enhancer activity is negatively regulated by a suppressor element in the intron 2/3 region. PMID: 21107579
41. Prolonged response to Retinoic Acid by posterior otic tissue correlates with Tbx1 transcription and formation of mostly nonsensory inner ear structures during development. PMID: 21173260
42. Ripply3 expression is observed in the pharyngeal ectoderm and endoderm and overlaps with strong expression of Tbx1 in the caudal pharyngeal endoderm. Ripply3 suppresses transcriptional activation by Tbx1 in luciferase assays in vitro. PMID: 21177346
43. Forced Fgf8 expression modifies and partially rescues the outflow tract septation defects of Tbx1 mutants but only if there is some residual expression of Tbx1. PMID: 20807544
44. Interferon-gamm deficient mice develop lower TH17 response, suggesting that IFN-gamma is not required for Tbx1-dependent activity. PMID: 20807701
45. Tbx1(-/+)/Pitx2(-/+) double heterozygous mice present with an extra premolar-like tooth revealing a genetic interaction between these factors. The ability of Tbx1 to repress PITX2 activation of p21 may promote cell proliferation. PMID: 20816801
46. Mesodermal Tbx1 is required for patterning the proximal mandible in mice. PMID: 20501333
47. Tbx1 is a critical transcription factor that guides palatal elongation and elevation and that Fgf8 expression in the palate is Tbx1-dependent. PMID: 20214979
48. Tbx1 and Ash2l have overlapping mRNA and protein expression patterns during development. PMID: 20463296
49. Pitx2-dependent occupancy by histone deacetylases is associated with T-box gene regulation in mammalian abdominal tissue PMID: 20129917
50. Results identify Wnt-beta-catenin signaling as a crucial upstream regulator of a Tbx1-Fgf8 signaling pathway and suggest that factors that affect Wnt-beta-catenin signaling could modify the incidence and severity of DGS. PMID: 20215350

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KEGG: mmu:21380

STRING: 10090.ENSMUSP00000009241

UniGene: Mm.295194