Recombinant Pig Protein S100-A12(S100A12)

Product Type Recombinant Protein
Uniprot No. P80310
Species Sus scrofa (Pig)
Gene Names S100A12
Protein Names Recommended name: Protein S100-A12 Alternative name(s): Calgranulin-C Short name= CAGC Extracellular newly identified RAGE-binding protein Short name= EN-RAGE S100 calcium-binding protein A12
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target Details This protein is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities.
Function S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites (By similarity).
Subcellular Location Secreted, Cytoplasm, Cytoplasm, cytoskeleton, Cell membrane, Peripheral membrane protein
Protein Families S-100 family
Tissue Specificity Found essentially in granulocytes with small amounts found in lymphocytes.
Database Links

KEGG: ssc:100301483

STRING: 9823.ENSSSCP00000007024

UniGene: Ssc.9117

Product Details for Different Expression Systems

Product Name Recombinant Pig Protein S100-A12(S100A12),Yeast
Code CSB-YP020626PI
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence TKLEDHLEG IINIFHQYSV RLGHYDTLIK RELKQLITKE LPNTLKNTKD QGTIDKIFQN LDANQDEQVS FKEFVVLVTD VLITAHDNIH KE
Expression Region 2-92
Protein Description Full Length of Mature Protein
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
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Product Name Recombinant Pig Protein S100-A12(S100A12),E.coli
Code CSB-EP020626PI
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence TKLEDHLEG IINIFHQYSV RLGHYDTLIK RELKQLITKE LPNTLKNTKD QGTIDKIFQN LDANQDEQVS FKEFVVLVTD VLITAHDNIH KE
Expression Region 2-92
Protein Description Full Length of Mature Protein
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Pig Protein S100-A12(S100A12),Baculovirus
Code CSB-BP020626PI
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence TKLEDHLEG IINIFHQYSV RLGHYDTLIK RELKQLITKE LPNTLKNTKD QGTIDKIFQN LDANQDEQVS FKEFVVLVTD VLITAHDNIH KE
Expression Region 2-92
Protein Description Full Length of Mature Protein
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Pig Protein S100-A12(S100A12),Mammalian cell
Code CSB-MP020626PI
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence TKLEDHLEG IINIFHQYSV RLGHYDTLIK RELKQLITKE LPNTLKNTKD QGTIDKIFQN LDANQDEQVS FKEFVVLVTD VLITAHDNIH KE
Expression Region 2-92
Protein Description Full Length of Mature Protein
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Still Have Questions? Leave a Message or Start an on-line Chat

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