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Recombinant Rat Canalicular multispecific organic anion transporter 2 (Abcc3), partial

Recombinant Rat Canalicular multispecific organic anion transporter 2 (Abcc3), partial

Code	CSB-YP001062RA
MSDS	MSDS
Size	Pls inquire
Source	Yeast
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Code	CSB-EP001062RA
MSDS	MSDS
Size	Pls inquire
Source	E.coli
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Code	CSB-EP001062RA-B
MSDS	MSDS
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP001062RA
MSDS	MSDS
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP001062RA
MSDS	MSDS
Size	Pls inquire
Source	Mammalian cell
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Abcc3

Uniprot No.

O88563

Alternative Names

Abcc3; Cmoat2; Mlp2; Mrp3; Canalicular multispecific organic anion transporter 2; ATP-binding cassette sub-family C member 3; MRP-like protein 2; MLP-2; Multidrug resistance-associated protein 3

Species

Rattus norvegicus (Rat)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

ATP-dependent transporter of the ATP-binding cassette (ABC) family that bind and hydrolyze ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes.

Gene References into Functions

This report is the first to describe liver overexpression of Abcc3 during the cancer initiation, promotion, and progression periods in rat hepatocarcinogenesis model and in human hepatocellular carcinoma PMID: 26337276
Ethynylestradiol increased the expression of hepatic Mrp3 transcriptionally and independently of any cholestatic manifestation and required participation of an ER, most likely ER-alpha, through its phosphorylation. PMID: 23077105
high expression of rat MRP3 in ileum and colon PMID: 11897632
Efflux of F-MTX is mediated by Mrp3 on the basolateral membrane of IEC-6 cells. PMID: 12909565
Conjugated bilirubin induces the mRNA expression of MRP2, which is a determinant of the in vivo cisplatin resistance of rat hepatoma cells PMID: 14981926

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Subcellular Location

Basolateral cell membrane; Multi-pass membrane protein.

Protein Families

ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily

Tissue Specificity

Expressed in lung, ileum, colon and liver. Higher in liver of Eisai hyperbilirubinemic rats.

Database Links

KEGG: rno:140668

UniGene: Rn.88248

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