Recombinant Rat Gamma-aminobutyric acid receptor subunit gamma-2 (Gabrg2), partial

1. RNF34 regulates postsynaptic gamma2-GABAAR clustering and GABAergic synaptic innervation by interacting with and ubiquitinating the gamma2-GABAAR subunit promoting GABAAR degradation PMID: 25193658
2. This study demonistrated that Gabrg2 receptors are located in cholinergic terminals in the nucleus pontis oralis of the rat. PMID: 24141149
3. This study provides evidence that alpha1F64, a key aromatic residue at the GABA binding site, is involved in both the binding and gating properties of alpha1beta1gamma2 receptors. PMID: 24573278
4. Switching the intracellular domains of the gamma2 and gamma1 subunits substantiated this inference. Because this region determines post-synaptic localization, we hypothesize that GABAARs containing gamma1 and gamma2 use different mechanisms for synaptic clustering. PMID: 24425869
5. These data demonstrate that altered expressions of GABA(A)R (alpha4, gamma2) and KCC2 and astrogliosis observed in TRMs hippocampus may provide us good therapeutic targets for the treatment of genetic epilepsy. PMID: 21924329
6. Significant reduction of gamma2 protein was observed in the hippocampus of the post-traumatic epilepsy group compared to control. PMID: 21439793
7. dispersal of GABA(A)R clusters and increased mobility of individual GABA(A)Rs are dependent on serine 327 within the intracellular loop of the GABA(A)R gamma2 subunit PMID: 20823221
8. The gamma2 subunit short splice variant serves dual roles, as an integral subunit of the GABA(A) receptor and as an accessory protein acting as an external modulator of GABA(A) receptor function. PMID: 20371809
9. The role of Gabrg2 in channel conductance in hippocampal neurons and the mechanism of protein interactions are reported. PMID: 19703932
10. Elevated quantities of GABA(A) receptor gamma 2 subunit mRNA in the rat are related to the highly advanced behavioral and mnemonic strategies that are under the control of the telencephalon in this mammal. PMID: 11845246
11. Prenatal DZ exposure produces functional modifications of the hippocampal GABA(A) receptor modulating NA release. DZ may affect gamma 2 subunit expression, so the receptor can be activated by muscimol but is not susceptible to allosteric modulation. PMID: 12145412
12. during synaptic maturation GABAAR gamma2 and beta3 subunits are able to associate with synaptic and extrasynaptic clusters of gephyrin; data are compatible with a role of gephyrin in GABAAR synaptic stabilization rather than in clusters formation PMID: 12812758
13. Transient kinetic techniques allow one to determine not only the channel-opening probability and rates of receptor desensitization but also the opening and closing rates of the mutated GABA(A) receptor channel PMID: 15182195
14. the postsynaptic clustering of GABA(A)Rs in pyramidal neurons is involved in the stabilization of the presynaptic GABAergic contacts PMID: 16248887
15. is suggested that during the menstrual cycle in women, plasticity of GABAA receptor subunit expression in brain regions such as the PAG. PMID: 16740643
16. GABA-A receptor subunit gamma 2-arginine-43 domain is involved in the control of receptor assembly that may be relevant to the effect of the heterozygous gamma 2(R43Q) mutation leading to childhood absence epilepsy and febrile seizure. PMID: 17148443
17. The K289M mutation of recombinant GABA(A)gamma2 receptor accelerates the decay of synaptic currents; in contrast, the R43Q mutation primarily reduces surface expression of recombinant gamma2 subunit. PMID: 18094250
18. Prostaglandin E2 attenuates preoptic expression of GABAA receptors via EP3 receptors PMID: 18292084
19. identify a gamma2-subunit-specific Yxxvarphi-type-binding motif for the clathrin adaptor protein, AP2, which is located within a site for gamma2-subunit tyrosine phosphorylation. PMID: 18305175
20. The GABAergic tonic inhibition demonstrated in this study may play a significant role in the sensory processing system of the Vc. PMID: 18585436
21. Data suggest that 3alpha,5alpha-THP's actions on dopamine type 1-like and/or GABAA receptors in the ventral tegmental area may require activity of protein kinase C. PMID: 18675324
22. a likely explanation for the generalized epilepsy with febrile seizures plus phenotype is a dominant-negative suppression of wild-type receptors by the mutant gamma2S subunit in combination with loss of mutant gamma2S subunit protein function. PMID: 19261880
23. Since the gamma2 subunit is involved with GABA(A) receptor trafficking and synaptic clustering, it appears that this subunit could be an important component of the activity-dependent response of the spinal cord after a spinal injury. PMID: 19358834
24. Collectively, our findings suggest that GABA(A) but not GABA(B) receptors in the tLH act to suppress feeding behavior. PMID: 19501070

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KEGG: rno:29709

STRING: 10116.ENSRNOP00000004619

UniGene: Rn.230132