Recombinant Rat Oxytocin-neurophysin 1 (Oxt)

1. Neuropeptide S evoked a significant somatodendritic release of oxytocin within the paraventricular nucleus. The anxiolytic effect of NPS seen after i.c.v. or intra-PVN infusion requires responsive OXT neurons of the PVN and locally released OXT. PMID: 29118105
2. Results define a novel rodent model of divergent stress effects on social affiliation and oxytocin signaling dependent on odor context. PMID: 26830961
3. Results suggest that oxytocin may be rewarding, and that this is not a result of the anxiolytic effects of oxytocin . PMID: 27529669
4. Under long term stressed conditions, the release of AVP and OXT from hypothalamus may vary depending on the content of the stressors. Central AVP appears to act oppositely to OXT by mediating CHeS-induced gastric motor maladaptation. Long term central AVP antagonism might be a pharmacological approach for the treatment of stress-related gastric motility disorders. PMID: 27829122
5. Chronic activation of oxytocin neurons restores the release of OXT from hypothalamic paraventricular nucleus fibers and prevents the hypertension that occurs with 3 wk of chronic intermittent hypoxia/hypercapnia exposure. PMID: 27016581
6. The -216- to -100-bp sequence in the 5'-flanking region of the oxytocin gene contains only an activator of transcription operating in the OXT-MCNs. PMID: 26177679
7. oxytocin expression may be modulated by dietary lipids in rats PMID: 25976631
8. a new regulatory mechanism is demonstrated for oxytocin to control the differentiation and fat accumulation in adipocytes via activation of Oxytocin receptor. PMID: 25702774
9. This study demonstrated that hypothalamic OT mRNA expression increased from the neonatal to the pre-pubertal period. PMID: 25637830
10. oxytocin has an effect on cognitive defect caused by chronic restraint stress applied to adolescent rats and on hippocampal VEGF and BDNF levels PMID: 25559382
11. Neonatal testosterone acts via ESR1 to suppress central pattern generators required for pulsatile oxytocin release. PMID: 24518793
12. Supraoptic nucleus neurons consist of two physiologically distinct populations preferentially expressing oxytocin or vasopressin. PMID: 25451978
13. These findings demonstrate an important contributory role of ANP in the OT induced protection in myocardial ischaemia reperfusion. OT also reduced lipid peroxidation with a NO-dependent mechanism. PMID: 25126708
14. Neonatal manipulation of oxytocin has developmental and sex-dependent effect on markers of brain plasticity. These results also indicate, that oxytocin may be protective against inflammation particularly in females. PMID: 25047873
15. Resistance training induces a significant reduction in the percentage of oxytocin-positive neurons, compared with sedentary controls. PMID: 23551170
16. The data suggested that behavioral despair could enhance OXT synthesis and secretion not only in the brain but also in the periphery. PMID: 24444823
17. Oxytocin activates intracellular calcium signaling in cultured rat primary sensory neurons in a dose- and PKC-dependent mechanism. PMID: 23912682
18. Endogenous GLP-1 targets PVN to restrict feeding behavior, in which the projection from NTS GLP-1 neurons and activation of CRH and nesfatin-1 neurons might be implicated. PMID: 25089000
19. The endocannabinoid anandamide decreases basal oxytocin and vasopressin secretion from rat neurohypophysis. PMID: 24342802
20. Data suggest Oxt is secreted by specific cells/neurons in supraoptic nucleus in lactation; such oxytocin cells appear to receive excitatory synaptic input mainly from contralateral supraoptic nucleus and paraventricular nucleus during milk ejection. PMID: 24042175
21. During repeated exposure to shorter stressors, an adaptation in oxytocin responses may occur. PMID: 23888412
22. Oxytocin in the medial preoptic area facilitates mating in both sexually naive and experienced males. Some of its effects are mediated by the oxytocin receptor. Sexual experience increased OTR expression in the MPOA. PMID: 23474276
23. Increased oxytocin activity is distributed in the periventricular nucleus of the hypothalamus in an animal model of sepsis. PMID: 23680380
24. results indicate that brain OXT is a critical mediator of social memory in male rodents and that, depending on the biological relevance of the social stimulus, distinct brain regions are recruited to mediate its effects PMID: 23102690
25. Oxytocin stimulates cardiomyogenesis by targeting cardiac side population cells. PMID: 24403294
26. Obesity is associated with reduced plasma oxytocin due to increased peptide degradation by liver and adipose tissue. PMID: 24389591
27. Neurophysin A was observed in the medial bank of frontal cortex, the anterior hippocampal rudiment, the rostral extension of substantia innominata, bed nucleus of stria terminalis, ventral pallidum, substantia innominata, and preoptic area. PMID: 24010161
28. kisspeptin-10 transiently excites oxytocin neurons in late pregnancy and during lactation, suggesting that a central kisspeptin excitation of oxytocin neurons emerges at the end of pregnancy PMID: 23550008
29. Angiotensin IV may act through the inhibition of the activity of insulin-regulated aminopeptidase to reduce the degradation of oxytocin at the spinal cord, thereby leading to anti-hyperalgesia in rats with inflammation. PMID: 23142109
30. Report role of peripheral chemoreceptor afferents in driving the plasticity of paraventricular oxytocinergic preautonomic neurons. PMID: 22872656
31. 5alpha-androstane-3beta,17beta-diol (3beta-diol), activates the oxytocin promoter through an estrogen receptor-beta pathway. PMID: 23515287
32. the oxytocin- and retinol-dependent increase of the PER1 expression and the subsequent change of ratio of efficiency of oxytocin and GABA at the prenatal stage of formation of the circadian clock-mechanism of the rat embryo anterior hypothalamus. PMID: 23136757
33. No difference is found in either quality or quantity of oxytocin- and vasopressin-immunoreactive neurons between individual rats of different social and reproductive ranks. PMID: 22266748
34. Data suggest that OXT expression is up-regulated in paraventricular nucleus by affiliative social behavior in response to stress; up-regulation of OXT expression may contribute to adaptation to reduce effects of stress on gastrointestinal tract. PMID: 22464293
35. In the mammalian peripartum period, the activity of both the brain oxytocin and vasopressin system is elevated as part of the physiological adaptations occurring in the mother--REVIEW PMID: 22100184
36. We review this and other work demonstrating that both vasopressin and oxytocin modulate conspecific social recognition at the level of the olfactory system--review PMID: 21920364
37. initial findings suggest that oxytocin and vasopressin systems may mediate early social environment-induced alterations in social behavior--REVIEW PMID: 22197269
38. An approximately 116 bp region upstream of the transcription start site (TSS) in the OXT gene promoter is responsible for conferring the selectivity of OXT gene expression. PMID: 22363799
39. female rat sexual behavior is modulated by the neuropeptide oxytocin through its actions in the hypothalamic ventromedial nucleus--review PMID: 22326383
40. central, but not peripheral, release of oxytocin plays an important role in response to chronic homotypic stress in rats PMID: 22245139
41. It was shown that oxytocin is necessary for the acquisition of filial preference. PMID: 21872599
42. Data suggest that estradiol may modulate secretion of oxytocin by hypothalamic neurons in response to increase in plasma osmolality induced by feeding; response involves neurons in both paraventricular hypothalamic nucleus and supraoptic nucleus. PMID: 22083216
43. Findings reveal that the positive consequences of mating in females are dependent on her ability to control sexual interactions, and that brain OT release is at least in part the underlying neurobiological correlate. PMID: 21858181
44. CRFR2 located on oxytocinergic neurons might regulate the release of this neuropeptide and might be a crucial part of potential feedback loop between the hypothalamic oxytocin system and the forebrain CRF system that impact affective and social behaviors. PMID: 21481539
45. Oxytocin in the periaqueductal gray participates in pain modulation in the rat by influencing endogenous opiate peptides. PMID: 21439337
46. oxytocin in the periaqueductal grey was involved in the antinociceptive process through the oxytocin receptor PMID: 21545817
47. central oxytocin inhibits acute restraint stress-induced CRF mRNA expression via GABA(A) receptors in the paraventricular nucleus PMID: 21382355
48. The expression of the clock gene per1, genes encoding vasopressin (AVP), vasoactive intestinal peptide (VIP) in the suprachiasmatic nucleus, and AVP and oxytocin (OXT) in the paraventricular nucleus were studied by in situ hybridization. PMID: 21061153
49. found a decrease of hypothalamic leucyl/cystinyl aminopeptidase activity and an increase in circulating levels of OXT PMID: 21207221
50. These results are indicative of a role of the NO-cGMP pathway in oxytocin/vasopressin synthesis in the SON and PVN of the hypothalamus during polymicrobial sepsis. PMID: 20621145

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KEGG: rno:25504

STRING: 10116.ENSRNOP00000028829

UniGene: Rn.48915