Recombinant Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Hcn1), partial

1. results implicate presynaptic NMDA receptor inhibition followed by reduced activity of presynaptic HCN1 channels, which would result in an increase in glutamate release and postsynaptic glutamate receptor activity, as a mechanism of ketamine action. PMID: 27965425
2. HCN channels play a critical role in the separation of overlapping movement responses and allow for successful reaching behaviours. These data provide a novel mechanism for the encoding of multiple movement responses within shared networks of motor cortex. This mechanism supports a viewpoint of primary motor cortex as a site of dynamic integration for behavioural output PMID: 27568501
3. Hyperpolarization-activated cyclic nucleotide-gated (HCN) 1 protein expression levels were increased in the thalamus under chronic pain condition. Results suggest, increased HCN channel activity in the thalamus of the ascending nociceptive pathway contributes to both chronic neuropathic and inflammatory pain conditions. PMID: 27542339
4. Here the Investigators overexpressed rat HCN1 in human embryonic kidney cells (HEK293) and recorded pharmacologically isolated cationic currents (Ih) in cell-attached or whole-cell mode of the patch-clamp technique. Recurring activation of HCN1 reduced and slowed Ih in intact HEK293 cells (cell-attached mode). PMID: 27184742
5. This study demonstrated that the aberrant changes of SST and NPY in several TRM brain regions(hcn1 mutation), suggesting that the peptidergic system might be involved in TRM epileptiform activity. PMID: 27685769
6. During the senescent process, the HCN2 and HCN4 protein levels declined. PMID: 26341471
7. Spatial learning and memory deficits in the chronic cerebral hypoperfusion model are associated with disturbed HCN1 and HCN2 surface expression in hippocampal CA1. PMID: 26021557
8. Hcn1 is a tremorgenic genetic component in a rat model of essential tremor. PMID: 25970616
9. Results suggest that HCN1 and HCN2 are expressed mainly by both the soma of mechanosensitive neurons in the trigeminal ganglion and peripheral axons of nociceptive neurons in the sensory root PMID: 25659346
10. Activation of GABAB receptors ameliorates cognitive impairment via restoring the balance of HCN1/HCN2 surface expression in the hippocampal CA1 area PMID: 24838625
11. these findings identify HCN1 channels as a novel neural target for type I interferons providing the possibility to tune neural responses PMID: 23042740
12. acute abrogation of HCN1-FLNa interaction in neurons, with the use of decoy peptides that mimic the FLNa-binding domain of HCN1, abolishes the punctate distribution of HCN1 channels in neuronal cell bodies PMID: 24403084
13. HCN1 contributes substantially to hyperpolarization-activated current properties in individual cortical plate neurons PMID: 23821600
14. High HCN1 expression induced by status epilepticus is responsible for epileptogenesis. PMID: 23187002
15. Data indicate that HCN1 and HCN2 form alternate ternary protein complexes with hair-cell stereociliary proteins. PMID: 22948144
16. This study demonistrated that Hi channel expression in area postrema neurons in the induction mechanism of nausea and vomiting. PMID: 22722099
17. knockdown of HCN1 channels in the hippocampus increased cellular excitability and resulted in physiological changes PMID: 22884333
18. TRIP8b isoforms are important regulators of HCN1 trafficking in entorhinal neurons. PMID: 22363812
19. Hyperpolarization current expression was high in corticospinal neurons and low in corticostriatal and corticocortical neurons, a pattern mirrored by mRNA levels for HCN1 and Trip8b subunits. PMID: 21795621
20. HCN1 band density in trigeminal ganglion neurons increased with postnatal age P1-P35. PMID: 21753027
21. This study demonistrated that the majority of LHb neurons projecting to the monoaminergic brainstem nuclei express a similar pattern of HCN transcripts, with high levels of HCN2 to HCN4 mRNAs and low levels of HCN1 mRNA PMID: 21798320
22. HCN1 channelopathy begins rapidly and persists after status epilepticus, involves both transcriptional and nontranscriptional mechanisms, and may be an early contributor to epileptogenesis. PMID: 21976514
23. I(h) modulates information processing in the hippocampus, and I(h)-mediated depolarization enhances the temporal precision of neuronal integration. PMID: 21326231
24. increasing cAMP levels in cells antagonized the up-regulation of HCN1 channels mediated by a TRIP8b construct binding the CNBD exclusively. PMID: 21504900
25. Heterologous expression of rat HCN1 gated ion channels suggests that cytosolic contents suppress hyperpolarization activated current I(h); such a mechanism might constitute a reserve in I(h)-channel function in vivo. PMID: 20806410
26. these results suggest that HCN channel activity can modulate the GABAergic synaptic transmission in the BLA, which in turn control the amygdala-related emotional behaviors such as anxiety. PMID: 21185265
27. These data provide additional information for the characterization of HCN1 mRNA as a new prospective target for the medication of vascular dementia. PMID: 19892002
28. in apical dendrites of hippocampal, subicular and neocortical layer-5 pyramidal cells PMID: 12389030
29. densely clustered at synaptic terminals of retinal bipolar cells and photoreceptors. PMID: 12786975
30. HCN1 and HCN2 expression were measured using in situ hybridization and immunocytochemistry in hippocampi; the expression of HCN isoforms is dynamically regulated in human as well as in experimental hippocampal epilepsy PMID: 12890777
31. HCN1 is distributed similarly to HCN2 along plasma membrane of dendritic shafts in layer I of the neocortex and stratum lacunosum moleculare of the hippocampal CA1 area, suggesting that these subunits could form heteromeric channels. PMID: 14991560
32. Strong HCN1 staining was present on octopus and bushy cells of the ventral cochlear nucleus, principal neurons of the lateral and medial superior olive, and neurons of the ventral nucleus of the lateral lemniscus. PMID: 15245481
33. These studies show that HCN1 and HCN2 channels in GABAergic GP neurons are key determinants of the regularity and rate of pacemaking as well as striatal resetting of this activity. PMID: 15525777
34. The present findings suggest that HCN1 channels may provide a significant route for modulating co-ordinated cerebellar synaptic transmission through basket cells. PMID: 15869503
35. Molecular basis for multiple actions of anesthetics on neuronal HCN channels, highlight the importance of proximal C terminus in modulation of HCN channel gating by diverse agents. PMID: 15958747
36. HCN1 subunit in the spinal cord and extend previous reports from the brainstem. PMID: 16503331
37. Data provide the first evidence that relatively mild changes in the neonatal environment have a long-term impact of absence seizures, Ih and HCN1, and suggest that an increase of Ih and HCN1 is associated with absence seizure reduction. PMID: 16820024
38. Loss of function of dendritic HCN1 channels in layer 5 pyramidal neurons provides a somato-dendritic mechanism for increasing the synchronization of cortical output, and is therefore likely to play an important role in the generation of absence seizures. PMID: 17095562
39. Expression and modulation of I(h)(via HCN1 channels) in the peripheral nervous system , including specialized sensory structures, may play a significant role in sensory processing and contribute to spontaneous pain and tactile allodynia. PMID: 17196750
40. Data show that hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channels influence the activity of globus pallidus neurons. PMID: 17439493
41. There is a role for HCN1 channel-mediated presynaptic I(h) in hippocampal maturation PMID: 17460082
42. The total number of hyperpolarization-activated cation current I (I[h]) channels, not their distribution in dendrites of pyramidal neurons, governs the degree of temporal summation of excitatory postsynaptic potentials. PMID: 17687042
43. redistributed HCN1 in CA1 pyramidal neurons. PMID: 17848552
44. Reduction in HCN1 channel expression is an accompaniment of epileptogenesis in different adult models of temporal lobe epilepsy. PMID: 18397293
45. HCN1 mRNAs were expressed in large diameter (55-80 microm) neurons of dorsal root ganalian in rat and HCN1 are present in large diameter neurons and small diameter neurons. PMID: 18450385
46. Overexpression of HCN1 channels blunts excitability of aortic baroreceptor neurons and baroreflex sensitivity in diabetic rats. PMID: 18524809
47. Aberrant h channel subunit trafficking contributes to h channelopathy in a rat model of temporal lobe epilepsy. PMID: 18657617
48. Competition may therefore exist in vivo between the two binding sites for HCN1, with binding of HCN1 to protocadherin 15 CD3 favored between 26.5 and 68 microm Ca(2+) PMID: 19008224

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KEGG: rno:84390

STRING: 10116.ENSRNOP00000016142

UniGene: Rn.21408