Recombinant Rat Protein BTG2 (Btg2)

Code CSB-YP002864RA
MSDS
Size Pls inquire
Source Yeast
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP002864RA
MSDS
Size Pls inquire
Source E.coli
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP002864RA-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-BP002864RA
MSDS
Size Pls inquire
Source Baculovirus
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-MP002864RA
MSDS
Size Pls inquire
Source Mammalian cell
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Purity
>85% (SDS-PAGE)
Target Names
Btg2
Uniprot No.
Alternative Names
Btg2; Pc3Protein BTG2; BTG family member 2; NGF-inducible anti-proliferative protein PC3
Species
Rattus norvegicus (Rat)
Expression Region
1-158
Target Protein Sequence
MSHGKRTDML PEIAAAVGFL TSLLRTRGCV SEQRLKVFSR ALQDALTDHY KHHWFPEKPS KGSGYRCIRI NHKMDPIISK VASQIGLSQP QLHQLLPSEL TLWVDPYEVS YRIGEDGSIC VLYEEAPVAT SYGLLTCKNQ MMLGRSSPSK NYVMTVSS
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors. Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.
Gene References into Functions
  1. PC3/Tis21 associates with HDAC1, HDAC4, and HDAC9 in vivo, in fibroblast cells. PMID: 27333946
  2. the present study provides us with a novel molecular mechanism of BTG2-mediated induction of hepatic gluconeogenesis and suggests that BTG2 plays an important role in hepatic glucose metabolism. PMID: 23058912
  3. Math1 was expressed on postnatal days 0 - 5 in rat greater epithelial ridge cells. PMID: 16335396
  4. These results suggest that PC3 is involved in the shift from proliferation to differentiation and maturation in the ganglion neurons of the rat cochlea. PMID: 19997037
  5. PC3 potentiates the induction of neuronal markers tyrosine hydroxylase and neurofilament 160 kDa protein, enhances nerve growth factor-induced differentiation and protects neurons from apoptosis. PMID: 11930152
  6. BTG2(TIS21/PC3) expression promotes neuronal differentiation and that it is required for survival of terminally differentiated cells. PMID: 12360398
  7. The role of NO in the enteric system is discussed with respect to neuronal nitric oxide synthase expression in neurons associated with the gut and the nerve growth factor and its receptor, tyrosine kinase A expression in the lamina epithelialis. PMID: 16191397
  8. A rat PC3 gene expressed in transgenic mice may prevent medulloblastoma development by controlling cell cycle and promoting differentiation of cerebellar granule cell precursors. PMID: 17371797
  9. PC3/Tis21/BTG2 is essential for terminal differentiation of neural progenitors. Genetic ablation of PC3/Tis21/BTG2 impairs terminal differentiation and shortens G1 phase of cell cycle duration of neural progenitor cells. PMID: 20020054
  10. PC3/Tis21/BTG2 promotes differentiation of neural cells and protects neurons from apoptosis. PMID: 11930152
  11. PC3/Tis21/BTG2 is a tumor suppressor of medulloblastoma PMID: 17371797
  12. The gene PC3/Tis21/BTG2 binds the histone deacetylases HDAC4 and HDAC1 and, as detected by chromatin immunoprecipitation, associates directly to the cyclin D1 promoter where it is likely to recruit the histone deacetylases. PMID: 17371797
  13. The gene BTG2/Tis21/PC3 inhibits cyclin D1 transcription and is a G1-S cell cycle phase checkpoint PMID: 10669755
  14. A comprehensive review of the different properties of the gene BTG2/Tis21/PC3 PMID: 11267995
  15. The gene PC3/Tis21/BTG2 potentiates the NGF-induced neural differentiation in vitro PMID: 11930152
  16. The gene BTG2/Tis21/PC3 induces the differentiation in vivo of cerebellar neural progenitors, acting on the transcription of the proneural gene Math1 PMID: 15056715

Show More

Hide All

Protein Families
BTG family
Tissue Specificity
In brain at embryonic day 13.5, placenta, amnion, and spleen, which are proliferating and/or differentiating.
Database Links
icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1