Recombinant Rat Transcriptional regulator ATRX(Atrx)

Product Type Recombinant Protein
Uniprot No. P70486
Species Rattus norvegicus (Rat)
Gene Names Atrx
Protein Names Recommended name: Transcriptional regulator ATRX EC= 3.6.4.12 Alternative name(s): ATP-dependent helicase ATRX X-linked nuclear protein pABP-2
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target Details This protein contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
HGNC 886
RGD 619795
MGI 103067
Function Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX
Subcellular Location Nucleus, Chromosome, telomere, Nucleus, PML body
Protein Families SNF2/RAD54 helicase family
Database Links

STRING: 10116.ENSRNOP00000041679

UniGene: Rn.107838

Product Details for Different Expression Systems

Product Name Recombinant Rat Transcriptional regulator ATRX(Atrx),Yeast
Code CSB-YP002437RA
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence GRSVVEFGDM VCKRQQSAVS SAGSEKPSGK EENVHSPEDK RVTKSKEKSK HLRTRTGRKV KSDVTDRFRK KEQSSESSEG EKKQGRQRTG TRGKKSTDLK EEKVKREREY ESSSDGTEKL PEGEEIGLFS KGVKQNKNDT TDEAKKGKKW KDKSCEKKEE LSDSVDRLPV KGESCDSSED KKTRNRVSLR EKKQFSLPAK SSGKRPECSS SDTERSVKGE CCDSTDKRVK RIDLRERRSS NSKRSTKEVK SGSSSSDAEG SSEDAKKQKK QRMSAKKKNS NTKERKRKSL RATTTKRKQA DITSSSSDIG DDDQNSAGEE SSDEQKIKPV TENLVLPSHT GFCQSSGDEA FSKSVPATVD DDDDDNDPEN RIAKKMLLEE IKANLSSDED GSSDDEPKEG EKKRIGKQSE ETPGDDGSNQ VNSESDSDSE ESKKPRYRHR LLRHKLSLSD GESGGEKKTK PKEHKETKGR NRRKVSSEDS EDTDFQESGV SEEVSESEDE QRPRTRSAKK AELEENQRSY KQKKKRR
Expression Region 1-527
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
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Product Name Recombinant Rat Transcriptional regulator ATRX(Atrx),E.coli
Code CSB-EP002437RA
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence GRSVVEFGDM VCKRQQSAVS SAGSEKPSGK EENVHSPEDK RVTKSKEKSK HLRTRTGRKV KSDVTDRFRK KEQSSESSEG EKKQGRQRTG TRGKKSTDLK EEKVKREREY ESSSDGTEKL PEGEEIGLFS KGVKQNKNDT TDEAKKGKKW KDKSCEKKEE LSDSVDRLPV KGESCDSSED KKTRNRVSLR EKKQFSLPAK SSGKRPECSS SDTERSVKGE CCDSTDKRVK RIDLRERRSS NSKRSTKEVK SGSSSSDAEG SSEDAKKQKK QRMSAKKKNS NTKERKRKSL RATTTKRKQA DITSSSSDIG DDDQNSAGEE SSDEQKIKPV TENLVLPSHT GFCQSSGDEA FSKSVPATVD DDDDDNDPEN RIAKKMLLEE IKANLSSDED GSSDDEPKEG EKKRIGKQSE ETPGDDGSNQ VNSESDSDSE ESKKPRYRHR LLRHKLSLSD GESGGEKKTK PKEHKETKGR NRRKVSSEDS EDTDFQESGV SEEVSESEDE QRPRTRSAKK AELEENQRSY KQKKKRR
Expression Region 1-527
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
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Product Name Recombinant Rat Transcriptional regulator ATRX(Atrx),Baculovirus
Code CSB-BP002437RA
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence GRSVVEFGDM VCKRQQSAVS SAGSEKPSGK EENVHSPEDK RVTKSKEKSK HLRTRTGRKV KSDVTDRFRK KEQSSESSEG EKKQGRQRTG TRGKKSTDLK EEKVKREREY ESSSDGTEKL PEGEEIGLFS KGVKQNKNDT TDEAKKGKKW KDKSCEKKEE LSDSVDRLPV KGESCDSSED KKTRNRVSLR EKKQFSLPAK SSGKRPECSS SDTERSVKGE CCDSTDKRVK RIDLRERRSS NSKRSTKEVK SGSSSSDAEG SSEDAKKQKK QRMSAKKKNS NTKERKRKSL RATTTKRKQA DITSSSSDIG DDDQNSAGEE SSDEQKIKPV TENLVLPSHT GFCQSSGDEA FSKSVPATVD DDDDDNDPEN RIAKKMLLEE IKANLSSDED GSSDDEPKEG EKKRIGKQSE ETPGDDGSNQ VNSESDSDSE ESKKPRYRHR LLRHKLSLSD GESGGEKKTK PKEHKETKGR NRRKVSSEDS EDTDFQESGV SEEVSESEDE QRPRTRSAKK AELEENQRSY KQKKKRR
Expression Region 1-527
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Rat Transcriptional regulator ATRX(Atrx),Mammalian cell
Code CSB-MP002437RA
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence GRSVVEFGDM VCKRQQSAVS SAGSEKPSGK EENVHSPEDK RVTKSKEKSK HLRTRTGRKV KSDVTDRFRK KEQSSESSEG EKKQGRQRTG TRGKKSTDLK EEKVKREREY ESSSDGTEKL PEGEEIGLFS KGVKQNKNDT TDEAKKGKKW KDKSCEKKEE LSDSVDRLPV KGESCDSSED KKTRNRVSLR EKKQFSLPAK SSGKRPECSS SDTERSVKGE CCDSTDKRVK RIDLRERRSS NSKRSTKEVK SGSSSSDAEG SSEDAKKQKK QRMSAKKKNS NTKERKRKSL RATTTKRKQA DITSSSSDIG DDDQNSAGEE SSDEQKIKPV TENLVLPSHT GFCQSSGDEA FSKSVPATVD DDDDDNDPEN RIAKKMLLEE IKANLSSDED GSSDDEPKEG EKKRIGKQSE ETPGDDGSNQ VNSESDSDSE ESKKPRYRHR LLRHKLSLSD GESGGEKKTK PKEHKETKGR NRRKVSSEDS EDTDFQESGV SEEVSESEDE QRPRTRSAKK AELEENQRSY KQKKKRR
Expression Region 1-527
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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