Recombinant Saccharomyces cerevisiae Structural maintenance of chromosomes protein 6 (SMC6), partial

1. Data suggest that aSmc5/6 likely links rDNA stability to overall mitotic growth. PMID: 29360860
2. Our findings reveal a requirement for the Smc5/6 complex, including Mms21/Nse2 mediated sumoylation, and topoisomerase-1 (Top1), for maintaining stability of a chromosome having low origin density and suggest a functional cooperation between the Smc5/6 complex and Top1 in maintenance of topologically challenged chromosomes prone to replication fork collapse or accumulation of torsional stress PMID: 28204881
3. Mph1 is a double-edged sword whose action at hybrids must be regulated by the Smc5/6 complex. This is underlined by the observation that simultaneous inactivation of RNase H2 and Smc5/6 results in Mph1-dependent synthetic lethality. PMID: 29281624
4. nse3-1/ sir4 Delta double mutants show additive defects for telomere shortening and TPE indicating the contribution of Smc5/6 to telomere homeostasis is only in partial overlap with SIR factor silencing. These findings support a role for Smc5/6 in telomere maintenance that is separate from its canonical role(s) in HR-mediated events during replication and telomere elongation. PMID: 27564449
5. The chromosomal association of the Smc5 and Smc6 complex depends on cohesion and predicts the level of sister chromatid entanglement. PMID: 25329383
6. Results show Smc5/6 essential roles and reveal that combined defects in DNA damage tolerance and pausing site-replication cause recombination-mediated DNA lesions. PMID: 26698660
7. The Smc5/6-Mms21 complex operates as a large SUMO ligase in vivo during DNA repair. PMID: 25764370
8. Smc5-Smc6 binds to a Mph1 region required for efficient fork regression, preventing assembly of Mph1 oligomers at the junction of DNA forks. PMID: 25439736
9. the Smc5/6 protein complex is directly involved in meiotic recombination and suggest that Smc6 plays a key role in resolving recombination intermediates during meiosis, especially those that form between sister chromatids. PMID: 24244180
10. Saccharomyces cerevisiae smc6 mutant survival, upon transient replication stress, can be improved by enhancing Mec1 checkpoint signaling. PMID: 23783034
11. Smc5/Smc6 complex binds single-stranded DNA and participates in DNA replication and repair. PMID: 21436624
12. Smc5/6 does not simply restrain the recombinogenic activity of Mph1 via direct binding. PMID: 21138837
13. Data suggest that the Smc5/6 complex and Esc2 prevent the accumulation of toxic recombination intermediates generated in replication-associated recombinational repair. PMID: 20444977
14. hypomorphic smc5 or smc6 alleles exhibit phenotypes similar to mms21 sumoylation-deficient mutants with regard to senescence and the accumulation of unresolved homologous recombination intermediates PMID: 20159973
15. Smc6 is involved in a pathway that requires Rad52 to function PMID: 15010319
16. The chromosome segregation is impaired in SMC6 mutant because the resolution of rDNA repeats is blocked during anaphase. PMID: 15793567
17. results further supporting the importance of Smc5-Smc6 in maintaining the integrity of the repetitive ribosomal DNA (rDNA) locus, the largest repetitive region of the budding yeast genome PMID: 15917663
18. Smc5/6-containing complexes have critical roles in both DNA repair and chromosome segregation PMID: 16452135
19. Smc5/6 complex is needed during replication to prevent the accumulation of branched chromosome structures. PMID: 16793545
20. The Smc5-Smc6 complex is essential for genome stability as it promotes repair of DSBs by error-free sister-chromatid recombination (SCR), thereby suppressing inappropriate non-sister recombination events. PMID: 16892052
21. Data show that the Smc5-Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus in Saccharomyces cerevisiae. PMID: 17643116
22. Esc2 and Smc5-6 act in concert with Sgs1 to prevent the accumulation of recombinogenic structures at damaged replication forks, likely by integrating sumoylation activities to regulate the repair pathways in response to damaged DNA PMID: 19158389
23. Structural and functional insights into the roles of the Mms21 subunit of the Smc5/6 complex. PMID: 19748359

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KEGG: sce:YLR383W

STRING: 4932.YLR383W