Recombinant Bovine Nuclear factor erythroid 2-related factor 1(NFE2L1)

Code CSB-CF015751BO
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. A5D7E9
Storage Buffer Tris-based buffer,50% glycerol
Species Bos taurus (Bovine)
Sequence MLSLKKYLTEGLLQFTILLSLIGVRVDVDTYLTSQLPPLREIILGPSSAYTQTQFHNLRNTLDGYGIHPKSIDLDNYFTARRLLNQVRALDRFQVPTTEVNAWLVHRDPEGSVSGSQPSSGLALESSSGLQDVTGPDNGVRESETEQGFSEDLEDLGAVAPPVSGDLTKEDIDLGAGREIFDYSHRQKEQDVDKELRDGAEQEDTWPGEGAEALARNLLVDGETGESFPAQVPGGEDQTALSLEECLRLLEATCPFGENAEFPADISSITEAVPSESEPPGLQNNLLSPLLTGTESPFDLEQQWQDLMSIMEMQAMEVNTSTSEVLYNAPPGDPLSTNYSLAPNTPINQNVSLHQASLGGCSQDFSLFSPEVESLPVASSSTLLPLVPSNSTSLNSTFGSTNLAGLFFPPQLNGTANDTAGPELPDPLGGLLDEAMLDEISLMDLAIEEGFNPVQASQLEEEFDSDSGLSLDSSHSPSSLSSSEGSSSSSSSSSSSSSSSASSSASSSFSEEGAVGYSSDSETLDLEEAEGAVGYQPEYSKFCRMSYQDPSQLSCLPYLEHVGHNHTYNMAPSALDSADLPPPSTLKKGSKEKQADFLDKQMSRDEHRARAMKIPFTNDKIINLPVEEFNELLSKYQLSEAQLSLIRDIRRRGKNKMAAQNCRKRKLDTILNLERDVEDLQRDKARLLREKVEFLRSLRQMKQKVQSLYQEVFGRLRDENGRPYSPSQYALQYAGDGSVLLIPRTLADQQARRQERKPKDRRK
Source in vitro E.coli expression system
Gene Names NFE2L1
Protein Names Recommended name: Nuclear factor erythroid 2-related factor 1 Short name= NF-E2-related factor 1 Short name= NFE2-related factor 1 Alternative name(s): Nuclear factor, erythroid derived 2, like 1
Expression Region 1-763
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Endoplasmic reticulum membrane sensor NFE2L1
Subcellular Location Endoplasmic reticulum membrane sensor NFE2L1: Endoplasmic reticulum membrane, Single-pass type II membrane protein, Endoplasmic reticulum membrane, Single-pass type III membrane protein, Note=In normal conditions, probably has a single-pass type II membrane protein topology, with the DNA-binding domain facing the endoplasmic reticulum lumen, Following cellular stress, it is rapidly and efficiently retrotranslocated to the cytosolic side of the membrane, a process dependent on p97/VCP, to have a single-pass type III membrane protein topology with the major part of the protein facing the cytosol, Retrotranslocated proteins are normally rapidly degraded by the proteasome and active species do not accumulate, However, retrotranslocated protein NFE2L1 escapes degradation and is cleaved at Leu-104 by DDI2, releasing the protein from the endoplasmic reticulum membrane and forming the transcription factor NRF1 that translocates into the nucleus, SUBCELLULAR LOCATION: Transcription factor NRF1: Nucleus
Protein Families BZIP family, CNC subfamily
Database Links

KEGG: bta:534582

STRING: 9913.ENSBTAP00000018147

UniGene: Bt.28567

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