Recombinant Mouse Delta-sarcoglycan (Sgcd)

Code CSB-CF021184MO
MSDS
Size Pls inquire
Source in vitro E.coli expression system
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Target Names
Sgcd
Uniprot No.
Alternative Names
Sgcd; Delta-sarcoglycan; Delta-SG; 35 kDa dystrophin-associated glycoprotein; 35DAG
Species
Mus musculus (Mouse)
Expression Region
1-289
Target Protein Sequence
MPQEQYSHHRSTMPSSEGPHIYKVGIYGWRKRCLYFFVLLLMILILVNLAMTIWILKVMNFTIDGMGNLRITEKGLKLEGDSEFLQPLYAKEIKSRPGNALYFKSARNVTVNILNDQTKVLTQLVTGPKAVEAYGKRFEVKTVSGKLLFSADDSEVVVGAERLRVLGAEGTVFPKSIETPNVRADPFKELRLESPTRSLVMEAPKGVEINAEAGNMEAICRSELRLESKDGEIKLDAAKIKLPRLPRGSYTPTGTRQKVFEVCVCANGRLFLSQAGTGSTCQINTSVCL
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Gene References into Functions
  1. Collectively, these results confirm and extend understanding of a functional role for the dystrophin-glycoprotein complex in the contractile properties of airway smooth muscle and demonstrate that this results in altered lung function in vivo. PMID: 25692961
  2. Myocardial expression of p.S151A cDNA, similar to intact Sgcd cDNA, restores cardiac function, although not being able to prevent myocardial histopathology in Sgcd-null mice completely. PMID: 23695275
  3. Despite SGC rescue, and contrary to previous observations obtained with WT/mdx chimeras low levels of ESC incorporation were insufficient to produce histological corrections in SGdelta-KO skeletal muscle or heart. PMID: 22328522
  4. This study supports a model where dystrophin, but not the sarcoglycans, protects the cardiac myocyte against mechanical damage. PMID: 21665956
  5. dystrophic phenotype observed in delta-sarcoglycan-null (Sgcd(-/-)) mice and dystrophin mutant mdx mice is dramatically improved by skeletal muscle-specific overexpression of sarcoplasmic reticulum Ca(2+) ATPase 1 (SERCA1) PMID: 21285509
  6. This study demonstrated that the severe cardiac dysfunction in Scgd(-/-) mice at 8 months. PMID: 20934875
  7. delta-SG isoforms may stabilize gamma-SG and microSPN in transverse tubules and sarcoplasmic reticulum membranes and this possible complex may play a role in maintenance of stable level of resting cytosolic calcium concentration in skeletal muscle. PMID: 20638123
  8. Abscence of sarcoglycan delta may be related to pathogenesis of muscular dystrophy. PMID: 19931597
  9. delta- and gamma-sarcoglycan prevent vascular spasm in coronary arteries and in vascular smooth muscle PMID: 14991064
  10. a delta-sarcoglycan isoform is localized at the sarcoplasmic reticulum of mouse skeletal muscle PMID: 16403451
  11. We propose that MDPCs may be the promising progenitor cells in skeletal muscle to treat delta-sarcoglycan complex mutant cardiomyopathy. PMID: 17150187
  12. The S151A delta-sarcoglycan gene mutation acts in a dominant negative manner to produce trafficking defects that disrupt nuclear localization of lamin A/C and emerin, thus linking together two common mechanisms of inherited cardiomyopathy. PMID: 17164264
  13. mdx and sgcd-/- arteries had decreased distensibilities in pressure-diameter tests, mdx arteries exhibiting elevated circumferential stresses, and mdx and sgcd-/- arteries generated elevated axial loads and stresses in axial force-length tests. PMID: 17525297
  14. Steroid treatment causes deterioration of myocardial function in the delta-sarcoglycan-deficient mouse model for dilated cardiomyopathy. PMID: 18495669
  15. These results indicate that mechanical stress is not a primary cause for the loss of other sarcoglycans (SG) when the delta-SG gene is deficient. PMID: 19083155
  16. Sub-physiological sarcoglycan expression plays a critical role in ameliorating muscle disease in mdx mice. PMID: 19131360

Show More

Hide All

Subcellular Location
Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasm, cytoskeleton.
Protein Families
Sarcoglycan beta/delta/gamma/zeta family
Tissue Specificity
Most strongly expressed in skeletal and heart muscle. Also detected in proliferating myoblasts.
Database Links
icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1