Recombinant Mouse Diacylglycerol O-acyltransferase 2 (Dgat2)

1. DGAT1 does not contribute to this pathway, but uses exogenous FA and glycerol to synthesize a functionally distinct pool of TAG to which DGAT2 also contributes...in b3-agonist activated brown adipocytes, DGAT2 specifically enables channelling of de novo synthesized FA into a rapidly mobilized pool of TAG, which is simultaneously hydrolyzed to provide substrates for mitochondrial fatty acid oxidation. PMID: 27836993
2. these results support a model where Dgat1 and Dgat2 function coordinately to regulate the process of dietary fat absorption by preferentially synthesizing TAG for incorporation into distinct subcellular TAG pools in enterocytes. PMID: 28249764
3. when intestinal DGAT2 is present in excess, mRNA levels of genes involved in fatty acid oxidation were reduced. This result suggests that reduced fatty acid oxidation may contribute to increased TG secretion by overexpression of DGAT2 in intestine PMID: 23643496
4. role of Mtp and DGAT2 in hepatic steatosis PMID: 22355095
5. DGAT2 is capable of catalyzing TG synthesis and promote its storage in cytosolic lipid droplets independent of its localization in the ER. PMID: 21680734
6. DAG-induced PKCepsilon activation plays a major role in nonalcoholic fatty liver disease (NAFLD)-associated hepatic insulin resistance. PMID: 21436037
7. Findings show that DGAT1 and DGAT2 account for the vast majority of TG synthesis in mice, and DGAT function is required for LDs in adipocytes, but not in all cell types. PMID: 21317108
8. upregulation of DGAT2 plays an important role in the pathogenesis of alcoholic fatty liver disease PMID: 20739640
9. the increased rate of hepatic TAG secretion and intracellular accumulation in ob/ob mice is accompanied by parallel increases in the activities of both DGAT I and DGAT II PMID: 12032764
10. role in assembly of de novo synthesized fatty acids into VLDL particles in the liver PMID: 12413942
11. DGAT2 expression is increased in diabetic mice. PMID: 14521909
12. plays a fundamental role in mammalian triglyceride synthesis and is required for survival PMID: 14668353
13. leptin regulates adipocyte size by altering expression patterns of DGAT via central nervous system to determine the levels of triglyceride synthesis. PMID: 15550388
14. DGAT1 but not DGAT2 has a role in VLDL synthesis; increased plasma VLDL concentrations may promote obesity, whereas increased DGAT2 activity has a role in steatosis PMID: 15797871
15. Hepatic DGAT2 overexpression resulted in 2.4-fold increases in the triglyceride content of liver PMID: 16877777
16. diacylglycerol acyltransferase 2 expression is regulated by CAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPalpha during adipogenesis PMID: 17504763
17. These findings indicate that the majority of triglyceride destined for secretion by liver is synthesized by DGAT2. PMID: 18252207
18. Consistent with pathways of hepatic triglyceride synthesis, expression of diacylglycerol acyltransferase-1 and -2 was increased, as were delta-5- and delta-6- fatty acid desaturase mRNA levels. PMID: 18280001
19. DGAT2, an ER-resident transmembrane domain-containing enzyme, is also found in mitochondria-associated membranes, where its N terminus may promote its association with mitochondria. PMID: 19049983

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KEGG: mmu:67800

STRING: 10090.ENSMUSP00000033001

UniGene: Mm.180189