Recombinant Mouse Endothelin B receptor(Ednrb)

Code CSB-CF007404MO
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names Ednrb
Uniprot No. P48302
Alternative Names EdnrbEndothelin receptor type B; ET-B; ET-BR; Endothelin receptor non-selective type
Species Mus musculus (Mouse)
Expression Region 27-442
Target Protein Sequence EKRGFPPAQATLSLLGTKEVMTPPTKTSWTRGSNSSLMRSSAPAEVTKGGRGAGVPPRSF PPPCQRNIEISKTFKYINTIVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALG DLLHIIIDIPINTYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASW SRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDMITSDYKGKPLRVCMLNPFQKTAFM QFYKTAKDWWLFSFYFCLPLAITAVFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVF CLVLVFALCWLPLHLSRILKLTLYDQSNPHRCELLSFLLVLDYIGINMASLNSCINPIAL YLVSKRFKNCFKSCLCCWCQTFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Essential component in the normal development of two neuronal crest-derived cell lineages.
Gene References into Functions
  1. ET-1 injection into the TG promotes ETAR/ETBR-mediated facial heat hyperalgesia, and both receptors are clearly implicated in Constriction of infraorbital Nerve-induced hyperalgesia in the murine Trigeminal system. PMID: 29570803
  2. Altered LAMA1 expression in the aganglionic region may contribute to impaired ENCC migration, resulting in HD. These data could help in understanding the pathophysiologic interactions between LAMA1 and ENCC migration PMID: 28983681
  3. Taken together with the finding that ETB R was expressed in Schwann cells, study results demonstrate that endothelin (ET) enhanced neurite outgrowth of neurons mediated by Na(+) /K(+) -ATPase via ETB R in Schwann cells. This study suggests that Na(+) /K(+) -ATPase coupled to the ET-ETB R system plays a critical role in peripheral nerve regeneration via lactate signalling. PMID: 28700113
  4. ETB receptor signaling is involved in skin sclerosis and in collagen synthesis by dermal fibroblasts PMID: 27209208
  5. mmLDL increased the serum concentrations and expression of ICAM-1 and VCAM-1 by activating the ERK1/2 pathway, resulting in the expression of ETB receptors and the enhancement of contractile function in vascular smooth muscle. PMID: 28797761
  6. ETB receptors in vascular smooth muscle make a small but significant contribution to ETB-dependent regulation of BP. These ETB receptors have no effect on vascular contraction or neointimal remodeling. PMID: 28028193
  7. Wnt-dependent EdnrB signaling can rescue the defects in melanocyte regeneration caused by Mc1R loss. PMID: 27134165
  8. we show that ET-1 acts selectively through EDNRB on astrocytes-and not oligodendrocyte progenitor cells-to indirectly inhibit remyelination. PMID: 26628380
  9. EDNRB plays a key role in hypoxia tolerance PMID: 26240367
  10. results indicate that the Notch1-STAT3-ETB(R) axis connects a signaling network that promotes reactive astrocyte proliferation after brain injury PMID: 26124113
  11. Ednrb-deficient mice showed altered goblet cell differentiation and surface mucus properties characteristic of human Hirschsprung disease. PMID: 24945437
  12. pathophysiological events in the brain in sepsis mediated by ET-1/ETB receptor axis, were evaluated. PMID: 24657829
  13. PROD-rol/rol mice with classic piebald mutation have two mutant genes, Ednrb and Cacna1a. PMID: 24758835
  14. ednrb expression in the heart was restricted to the endocardium and coronary endothelium PMID: 25050930
  15. Podocyte endothelin type B receptors significantly contribute to diabetes-induced activation of the beta-catenin cascade. PMID: 24722437
  16. The -615 to -624 bp region is the key binding site of AP-1 in ETB receptor promoter and was found to be crucial for inducible ETB receptor expression. PMID: 24265756
  17. Germline mutation and subsequent promoter methylation of Ednrb may be relevant to cancer susceptibility in the JF1/Ms mice. These data indicate that Ednrb acts as a tumor suppressor. PMID: 24194353
  18. analysis of interactions between neurofibromin and endothelin receptor B in developing mice PMID: 23555837
  19. without EDNRB excessive ovulation occurs, suggesting a role of EDNRB in having the extent of ovulation confined PMID: 22406076
  20. results are consistent with ETB receptor activation playing an important role in limiting neointimal lesion formation following acute vascular injury PMID: 22467315
  21. In a mouse cancer pain model, EDNRB methylation is a novel regulatory mechanism and suggests that ETB receptor re-expression attenuates cancer-induced pain. PMID: 21782343
  22. Whole-genome scanning for quantitative trait loci (QTLs) using an intercross of (AGH-Ednrb(sl)xF344-Ednrb(sl)) F(1) with the varying severity of aganglionosis, is reported. PMID: 22132166
  23. Knock-out of endothelin B receptor increases epithelial sodium channel activity in the kidney collecting duct. PMID: 21918182
  24. ET(B) receptor expression in vascular advential fibroblasts increases the clearance of the ET-1 peptide. PMID: 21949113
  25. ET-B-receptor-mediated assembly signals drive cell nuclear migration that precedes neurogenesis. PMID: 21130129
  26. Partial requirement of endothelin receptor B in spiral ganglion neurons for postnatal development of hearing. PMID: 21715336
  27. The acid-activated pathway mediating stimulation of kidney NaDC-1 activity requires a functional ET(B) receptor in vivo and in vitro. PMID: 20703215
  28. Endothelin B receptor stimulation inhibits suicidal erythrocyte death. PMID: 20427706
  29. Rosiglitazone attenuated ET-1-induced vasoconstriction through the upregulation of endothelial ET(B)R PMID: 20516393
  30. Vascular smooth muscle cells express both ETA and ETB, which mediate a direct vasoconstrictor action of ET-1 PMID: 20516397
  31. Melanomas from RET mice exhibited decreased expression levels of endothelin receptor B (Ednrb) compared with benign tumors PMID: 20048069
  32. We here describe a novel mutant mouse with a mutation of the Ednrb gene, and propose the mouse as an animal model of Waardenburg Syndrome type 4. PMID: 11773966
  33. determination of the molecular basis of embryonic arrest from defects associated with mesoderm development PMID: 11829485
  34. Differentiation of murine melanocyte precursors induced by 1,25-dihydroxyvitamin D3 is associated with the stimulation of endothelin B receptor expression. PMID: 12230499
  35. endothelin-B receptor has an antiproliferative role in the injured artery PMID: 12370225
  36. endothelin receptor type B binds to and activates Galpha13 protein via three intracellular loops on EDNRB PMID: 12441350
  37. interaction with Ret in model of Hirschsprung disease PMID: 12574515
  38. EDNRB-mediated signaling is required for the terminal migration of melanoblasts and enteric neuron precursors. PMID: 12812796
  39. Along with the increase of ET-1 mRNA level, we observed approximately a 2-fold increase in the ET-b mRNA level in the ischemia/reperfused liver... P. 115 PMID: 14969349
  40. regulation by SOX10 in the enteric nervous system PMID: 15170213
  41. Ednrb plays a significant role during melanocyte differentiation and effects melanocyte development by both cell non-autonomous and cell-autonomous signaling mechanisms PMID: 15201217
  42. Describe the generation of mice that possess a beta-galactosidase reporter gene introduced into the endothelin-B receptor locus by homologous recombination in embryonic stem cells. PMID: 15838265
  43. Report immunolocalization of endothelin-B receptor in mouse intestinal tract. PMID: 15838312
  44. The Endothelin receptors B (Ednrb) are involved in the development of the enteric and melanocytic lineages, which originate from neural crest cells (NCCs). PMID: 15892714
  45. SOX10 does not directly activate Ednrb transcription in the melanocyte lineage. PMID: 16412618
  46. the endothelin receptor type B gene reduced expression in piebald mice is caused by insertion of a retroposon-like element in intron 1 PMID: 16500897
  47. The endothelial cell endothelin B receptor mediates a tonic vasodilator effect and nonendothelial cell endothelin B receptors are important for the regulation of blood pressure. PMID: 16801484
  48. the collecting duct ETB receptor partially mediates the antihypertensive and natriuretic effects of ET-1 PMID: 16868309
  49. We concluded that the deletion in the Ednrb gene is the causative mutation for the phenotype of WS4 mice. PMID: 17090968
  50. reactive astrocytes have a protective role in brain ischemia, and the absence of astrocyte intermediate filament proteins is linked to changes in glutamate transport, ET(B)R-mediated control of gap junctions, and PAI-1 expression PMID: 17726492

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Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 1 family, Endothelin receptor subfamily, EDNRB sub-subfamily
Database Links

KEGG: mmu:13618

STRING: 10090.ENSMUSP00000022718

UniGene: Mm.229532

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