Recombinant Mouse Gap junction beta-6 protein (Gjb6)

1. Data show that the passive compliance of the cochlear partition and active frequency tuning of the basilar membrane are enhanced in the cochleae of CD-1onnexin-30 (Cx30)(A88V/A88V) compared to CBA/J mice with sensitive high-frequency hearing. PMID: 28220769
2. Results demonstrate that Cx43, but not Cx30, is crucial for adult neurogenesis in the hippocampus. PMID: 28689039
3. connexin 30 controls astroglial polarity during development PMID: 29475972
4. In Cx30 and Cx26 knock-out animals, inner hair cells remained stuck at a prehearing stage of development. PMID: 28077706
5. Connexin 30, but not connexin 43, hemichannels close upon protein kinase C activation, illustrating that connexin hemichannels display not only isoform-specific permeability profiles but also isoform-specific regulation by protein kinase C. PMID: 26400258
6. four unique Cx30 mutants might cause disease through different mechanisms that also likely include their selective trans-dominant effects on coexpressed connexins. PMID: 24522190
7. The cortex modafinil injection increases the expression of mRNA and protein of connexin 30. PMID: 23665355
8. The Cx30A88V mutation triggers hyperproliferation in the skin and changes the cochlear homeostasis in mice. PMID: 24685692
9. Connexin30 is expressed at significantly higher levels in the buccal mucosa than the epidermis and, unlike in skin, it is rapidly down-regulated at the wound edge within 6 hours of wounding. This may underlie the rapid healing of the buccal mucosa. PMID: 23627777
10. The observations demonstrate a role for Cx30 and intercellular communication in regulating repair responses in an epithelial tissue. PMID: 23424196
11. We showed co-expression of Cx30 and p63 in developing mouse hair follicles and nail units. PMID: 23219093
12. in the Cx30 knock-out mouse model, defective Cx26 expression is the likely cause of deafness, and in contrast to current opinion, Cx30 is dispensable for cochlear functions PMID: 23303923
13. This study demonistrated that Cx30/Cx47 double-deficient mice has the functional role of both connexins for interastrocytic, interoligodendrocytic, and panglial coupling, and show that both connexins are required for maintenance of myelin. PMID: 22649229
14. Loss of Cx30 and the white matter pathology observed does not affect expression of experimental autoimmune encephalitis; astrocyte gap junctions do not regulate autoimmune inflammation. PMID: 22342190
15. This study suggested that cx30 defiency affect expression levels of glial glutamate transporters within the cerebrum. PMID: 22037505
16. Employing tracer coupling analyses in acute slices of Cx30 deficient mice demonstrate that Cx30 makes a substantial contribution to interastrocytic gap junctional communication in the mouse hippocampus. PMID: 21264956
17. These results of this study suggested that alterations of astrocyte connexins might be involved in the suicide process and provide further evidence implicating astrocytes in psychopathology. PMID: 21571253
18. loss of the ability of ENaC to respond to changes in sodium levels contributes to salt-sensitive hypertension in Cx30(-/-) mice PMID: 21075848
19. Cx30 is functionally expressed, in low abundance, in the SA node of the adult mouse heart where it participates in heart rate regulation. PMID: 19679680
20. Cx30 (Gjb6) deficient mice exhibit a severe constitutive hearing impairment.The Cx30 deficient mice may represent a valuable model to study the mechanism of the hearing loss in human patients carrying a homozygous deletion of the CX30 gene . PMID: 12490528
21. Elimination of connexin30 can alter reactivity to novel environments. Importance of gap-junctional signalling in behavioural processes. PMID: 12911759
22. Cx30 is abundant in late-pregnant and early lactating gland epithelium. PMID: 17120054
23. In the absence of the Cx30 gene, Cx26 expressed from extra alleles completely restored hearing sensitivity and prevented hair cell death in deaf Cx30-/- mice PMID: 17227867
24. Connexin30 deficiency causes instrastrial fluid-blood barrier disruption within the cochlear stria vascularis. PMID: 17400755
25. Cx30 immunoreactivity was found extensively in vestibular supporting cells and connective tissue cells. PMID: 17702002
26. Expression of Cx30 and Cx43 a is upregulated in cortical astrocytes cocultured with neurons. PMID: 18512249
27. effects of Cx30 null mutation on GJ-mediated ionic and metabolic coupling in the cochlea of mice PMID: 19116647
28. Mechanosensitive Cx30 hemichannels have an integral role in pressure natriuresis by releasing ATP into the tubular fluid, which inhibits salt and water reabsorption. PMID: 19478095

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KEGG: mmu:14623

STRING: 10090.ENSMUSP00000035630

UniGene: Mm.25652