Recombinant Mouse Myelin proteolipid protein (Plp1)

1. These results suggest that colitis promotes rapid enteric neurogenesis in adult mice and humans through differentiation of Sox2- and PLP1-expressing cells, which represent enteric glia and/or neural progenitors PMID: 28566702
2. This study demonstrated that Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2. PMID: 28836307
3. The rumpshaker missense mutation in the Plp1 gene gives rise to subcortical myoclonus PMID: 28382685
4. axonal mitochondria, smooth endoplasmic reticulum, and microtubules were characterized in rodent optic nerves where PLP is replaced by the peripheral nerve myelin protein, P0. PMID: 27872255
5. The observations collectively support the idea that GST-pi(Nuc)/DM-20 mRNA-expressing cells are the progeny of NG2-positive OPCs rather than a novel type of oligodendrocyte-lineage progenitor cells and that DM-20 mRNA expression is dynamically regulated during differentiation of OPCs into oligodendrocytes. PMID: 26921198
6. Both extracellular and intracellular epitopes of PLP contribute to the pathogenesis of MP4-induced experimental autoimmune encephalomyelitis already in the setting of intact myelin. PMID: 25959684
7. The insertion of native PLP into Olg mitochondria of animals with PLP1/Plp1 regulates extracellular pH and adenosine triphosphate. PMID: 24382809
8. This study shows for the first time that Plp-null mice exhibit severe early-onset thermal hyperalgesia that is not associated with changes in thermal allodynic behavior. PMID: 24423646
9. A novel mechanism sheds light on the immune regulation by which sulfatide-reactive type II natural killer (NK)T cells suppress inflammatory class II histocompatibility-restricted pathogenic CD4+ T cell responses in a T cell-mediated autoimmune disease. PMID: 24973441
10. that an early reactive glia response occurs following mutations in the PLP gene PMID: 24314267
11. Result suggest that plp1 plays a role either in the structural integrity of oligodendrocyte progenitor cell processes or in their response to extracellular cues that orient process outgrowth. PMID: 24453324
12. PLP contributes to the high cholesterol content of myelin by association and co-transport in the central nervous system. PMID: 23322581
13. Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum. PMID: 23492777
14. PLP1 mutants inhibit Golgi apparatus to endoplasmic reticulum trafficking and have a role in pathogenesis of Pelizaeus-Merzbacher disease PMID: 23344956
15. The results presented here suggest that the antisilencer/enhancer is largely dispensable for the developmental regulation of Plp1 gene expression in vivo. PMID: 23157328
16. Our data indicate that miR-20a, a component of the cluster that controls oligodendrocyte cell number, regulates myelin proteolipid protein gene expression PMID: 22504928
17. PLP gene expression is evident in both neuronal and oligodendroglial phenotypes in developing neostriatum. PMID: 21912090
18. The developmental increase in Plp1 gene expression that occurs during the active myelination period is governed by transcription regulatory elements present within the first intron. PMID: 21472765
19. Plp promoter activity is not restricted to the myelinating cell lineage, but rather, has widespread activity both during embryonic and early postnatal development. PMID: 21572962
20. We conclude that PLP reaches the cell surface via at least two trafficking pathways with distinct regulations PMID: 21490207
21. Central nervous system myelination is compromised by overexpression of proteolipid protein PLP/DM20 in a transgenic mouse model of Pelizaeus-Merzbacher disease. PMID: 20629189
22. restoring wild-type PLP/DM20 levels in rumpshaker improves the phenotype and the integrity of myelin, but hypomyelination persists and stress pathways remain activated; both gain- and loss-of-function mechanisms may be involved in the pathogenesis PMID: 20175203
23. the data of this study proved that PLP promoter-expressing OPCs continue to generate glutamatergic pyramidal neurons in the adult piriform cortex. PMID: 20826667
24. Plp expression in medulla neurons was restricted to neurons with specific ligand-gated channels & biosynthetic enzymes in defined areas. It was seldom found in GABA interneurons & never in AMPA receptor- or tyrosine hydroxylase-expressing neurons. PMID: 19479988
25. Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/lysosomes PMID: 11956232
26. Plp gene repression is mediated through the combinatorial action of both "general" and cell type-specific negative regulatory elements PMID: 12091477
27. PLP and DM20 form a hetero-oligomeric complex within the myelin sheath, probably in association with specific lipids in an arrangement essential for the normal structure of myelin and axons. PMID: 12112373
28. Plp intron 1 DNA regulates proper developmental expression during (and following) the active myelination period of brain development. PMID: 12358743
29. The rumpshaker mutation of the proteolipid protein (Plp) gene causes dysmyelination in man and mouse; the phenotype in mouse depends critically on the genetic background in which the mutation is expressed. PMID: 12645075
30. Data show that calnexin associates with newly synthesized proteolipid protein (PLP) molecules, binding stably to misfolded PLP. PMID: 12805210
31. A family of PLP gene splice products, soma-restricted (sr) PLP/DM20 proteins, is mainly expressed in developing thymocytes in thymus and in T- and B-lymphocytes in spleen; srDM20 is the predominant isoform compared to srPLP in these tissues and cells. PMID: 14597093
32. sr-isoforms of the proteolipid protein gene have a biological role independent of myelination PMID: 15139298
33. These studies show that the level of native Proteolipid Protein modulates the amount of programmed cell death during normal development via a pH-dependent mechanism. PMID: 15375385
34. A mannosylated form of myelin proteolipid protein (amino acids 139-151) induces peptide-specific tolerance to experimental autoimmune encephalomyelitis via a mechanism of deletion or impaired migration of encephalitogenic T cells. PMID: 15710471
35. Data support the hypothesis that the myelin P0 Protein to myelin proteolipid protein shift during vertebrate evolution provided a vital neuroprotective function to myelin-forming CNS glia. PMID: 16449196
36. Using the mouse model, we show that the low steady state levels of PLP result from accelerated proteasomal degradation rather than decreased synthesis. The T(1/2) for degradation of rumpshaker PLP is 11 h compared with 23 h for wild type. PMID: 16506223
37. Direct or indirect role for PLP in maintaining myelin compaction along the external surfaces of the lamellae and to a limited extent, along the cytoplasmic surfaces as well and also in maintaining the normal alignment of the radial component. PMID: 16802387
38. These findings provide strong evidence that a primary glial damage can cause secondary immune reactions of pathological significance as it has been suggested for some forms of multiple sclerosis and other leukodystrophies. PMID: 16885234
39. increased Plp1 gene dosage affects other myelin proteins, particularly MBP PMID: 17133418
40. expression of mutated PLP protein downregulates Plp gene activity both in oligodendrocytes, which eventually die, and in Schwann cells, which are apparently unaffected in Plp(jp) mice. PMID: 17191136
41. Most expressed developmental and cell-specific subprograms accommodated within the known expression phenotype of the plp/DM20 locus, thus defining components of the combinatorial mechanism controlling its normal temporal and cell-specific program. PMID: 18596164
42. intronic splicing enhancer is necessary for the developmental increase in PLP1/DM20 ratio and full PLP1 dosage is necessary for myelin stability and brain function PMID: 18835559
43. Results suggest that the splice variants, along with those containing another alternatively spliced exon (exon 1.1) derived from intron 1 sequence, give rise to multiple Plp1 gene products in the mouse testis. PMID: 19232385
44. This study performed extensive analyses on the behavior of 2-month-old plp1tg/- mice, and found that they displayed various behavioral abnormalities indicative of cognitive dysfunction that may be interpreted as schizophrenia-like behavior. PMID: 19571127
45. This paper shows that the lipophilin family of proteolipid proteins is evolutionarily conserved from invertebrates and that the primordial gene is M6A-like. PMID: 10818135
46. This paper defines motifs in the second extracellular domain of lipophilin family proteins that divides them into M6A-like and DM-20/M6B-like subfamilies. PMID: 9418954

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KEGG: mmu:18823

STRING: 10090.ENSMUSP00000033800

UniGene: Mm.1268