Recombinant Mouse Trimeric intracellular cation channel type B(Tmem38b)

Code CSB-CF872037MO
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names Tmem38b
Uniprot No. Q9DAV9
Alternative Names Tmem38b; D4Ertd89e; Mg33b; Trimeric intracellular cation channel type B; TRIC-B; TRICB; Mitsugumin-33B; Transmembrane protein 38B
Species Mus musculus (Mouse)
Expression Region 1-292
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.
Gene References into Functions
  1. TRIC-B function is essential to support the production and release of large amounts of collagen by osteoblasts, which is necessary for bone mineralization PMID: 27188440
  2. This mini-review focuses on the essential role of TRIC-B channels in bone ossification. PMID: 27803445
  3. Study found that a simplified, linear, six-state gating model best encompasses the complexity of the subconductance gating behavior of TRIC-B channels PMID: 26200862
  4. Rapid transitions between TRIC-B sub-conductance states prevented development of reliable gating models. PMID: 23467973
  5. TRIC-A and TRIC-B seem to have differential functions in Ca(2+) signaling in excitable and nonexcitable cells. PMID: 24526676
  6. TRIC channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores PMID: 17611541
  7. TRIC-B-knockout neonates were cyanotic owing to respiratory failure and died shortly after birth. In mutant neonates, the deflated lungs exhibited severe histological defects, and alveolar type II epithelial cells displayed ultrastructural abnormalities. PMID: 19515693

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Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein Families TMEM38 family
Tissue Specificity Widely expressed.
Database Links

KEGG: mmu:52076

STRING: 10090.ENSMUSP00000030127

UniGene: Mm.27184

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