Recombinant Rat ATP-sensitive inward rectifier potassium channel 11 (Kcnj11)

1. The E23K variant of the KATP channel increased the susceptibility to ventricular arrhythmia under acute ischemia stress. PMID: 28082085
2. Data show that sarcolemmal ATP-sensitive K+ (sarcKATP) channel mutant subunit Kir6.2AAA transfection inhibited the channel activity and significantly aggravated the apoptosis of myocytes induced by lipopolysaccharides (LPS). PMID: 27430376
3. Findings suggest that Kir6.2 expression in the spinal cord is reduced in bone cancer pain and activation of Kir6.2 at the spinal level reduces pain hypersensitivity associated with bone cancer pain PMID: 24480471
4. Kir6.2 plays a central role in ischemic preconditioning and calcium and mitochondrial homeostasis during stress, and the impact of decreasing channel number is deleterious to myocyte survival. PMID: 24014680
5. The G156P mutation reduces the ability of PIP2 to stabilize the open state of Kir6.2 channels. PMID: 23700433
6. Estradiol significantly upregulates the expression of KATP channel subunits and SUR1 activity in the brain cortices of ovariectomized rats. PMID: 23032400
7. A set of the Linear Interaction Energy method parameters was defined that may enable prediction of the effects of additional Kir6.2 mutations within the ATP binding site on the affinity for ATP. PMID: 23219002
8. Channels bearing Q52E mutation in Kir6.2 and E203C in SUR1 exhibit ATP sensitivity 100-fold higher than wild-type channels. PMID: 22802363
9. Binding of HIF-2alpha to a putative hypoxia response element in Kir6.2 gene promoter is validated in adrenal glands from pups born to dams exposed to nicotine throughout gestation. PMID: 22403787
10. Activation of astrocytic mitochondrial K(ATP) channels improves gap junction function in astrocytes via regulation of gap junction-coupled spatial buffering in the hippocampus. PMID: 21474909
11. ATP activates ATP-sensitive potassium channels composed of mutant sulfonylurea receptor 1 and Kir6.2 with diminished PIP2 sensitivity. PMID: 21654216
12. Identify a critical determinant in TMD0 that controls Kir6.2 gating by controlling channel sensitivity to PIP(2). Uncover a novel mechanism of K(ATP) channel inactivation involving aberrant functional coupling between SUR1 and Kir6.2. PMID: 21321069
13. The activity of K(ATP) channels in hippocampal H19-7 neurons treated with or without short interfering RNAs (siRNAs) directed against Kir6.2 mRNA was investigated in this study. PMID: 21145327
14. The gastric responses to hyperglycemia and tolbutamide were not observed in rats with Kir6.2 small interfering RNA-treated nodose ganglia. PMID: 21193530
15. Kir6.2 was found in most rat brain neuronal populations. Both oligodendrocytes and astrocytes contain Kir6.2. It was found in the endoplasmic reticulum, Golgi apparatus and cell membranes of glia and neurons. PMID: 12007828
16. activation of KATP channels in slow-twitch muscle is necessary for activation of the NKCC and cell volume restoration in hyperosmotic conditions. PMID: 14592811
17. There is a direct interaction between Kir6.2 and a 65-amino-acid section of the cytoplasmic C-terminal region of rSUR2A between residues 1294 and 1358. PMID: 14672537
18. KATP channels play an important role in glucose sensing and insulin secretion, and ribozyme Kir6.2-gene targeting is an effective approach for selective inhibition of functional expression of KATP channels. PMID: 15166124
19. expression of Kir6.2 in the rat intestine is moderated by Isl-1 PMID: 15528203
20. Zinc activated KATP in cells co-expressing rat Kir6.2 and SUR1 subunits. PMID: 15613469
21. Kir6.2 to be widely expressed in all brain regions, suggesting that the Kir6.2 subunit forms the pore of the K-ATP channels in most neurons PMID: 15739238
22. Mutations in this gene should be taken into consideration for not only permanent neonatal diabetes but also other forms of diabetes with milder phenotypes and later onset. PMID: 15784703
23. These results suggest that 14,15-EET activates vascular K(ATP) channels through ADP-ribosylation of G(s)alpha. PMID: 16537788
24. findings show that PNDM mutations, including Q52R, V59G, V59M, R201C, R201H, and I296L, not only reduce channel ATP sensitivity but also impair channel expression at the cell surface to varying degrees PMID: 16731837
25. sulfonylureas also reverse trafficking defects caused by neonatal diabetes-associated Kir6.2 mutations in a way that is dependent on intact sulfonylurea binding sites in sulfonylurea receptor 1 further support this notion PMID: 16956886
26. changes in hypothalamic Kir6.2 expression may be associated with the development of hyperinsulinaemia and hyperglycaemia PMID: 18001323
27. HSP90 is involved in K ATP-mediated cytoprotection, possibly by promoting mitochondrial targeting of Kir6.2. PMID: 18006464
28. the importance of Kir6.2 subunit-subunit interactions in K(ATP) channel gating and function and reveal a novel gating defect underlying CHI. PMID: 18250167
29. observations are consistent with the hypothesis that testosterone modulates male sexual behavior by regulating K(+)(ATP) channels in the brain PMID: 18950632
30. Kir6.2 was found to be positively regulated by ARNT at the mRNA and protein levels. PMID: 19141293

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KEGG: rno:83535

STRING: 10116.ENSRNOP00000028685

UniGene: Rn.3985