Recombinant Rat Potassium voltage-gated channel subfamily C member 1 (Kcnc1)

1. Trafficking-dependent roles of the Kv3.1b potassium channel are dependent on N229 site-specific glycosylation and N-glycan structure, and operate through a mechanism whereby specific N-glycan structures regulate cell surface expression. PMID: 28322444
2. This study demonstrated that Kv3.1b potassium channel expression in motor cortex pyramidal cells. PMID: 28213922
3. Our findings provide direct evidence that N-glycans of Kv3.1 splice variants contribute to the placement of these glycoproteins in the plasma membrane of neuronal-derived cells while those of Kv1.1 were absent. PMID: 26348848
4. Results indicate that Src kinase may play an important role in regulating membrane trafficking of Kv3.1b channels. PMID: 24291260
5. high-affinity multimeric binding between the Kv3.1 T1 domain and KIF5B requires three basic residues in the KIF5B tail. Kv3.1 T1 competes with the motor domain and microtubules, but not with kinesin light chain 1 (KLC1), for binding to the KIF5B tail. PMID: 23487040
6. The unique N-terminus of DPP6K modulates the effects of KChIP proteins, slowing recovery and producing a negative shift in the steady-state inactivation curve. PMID: 22675523
7. alternative splicing controls neuronal firing rates by regulating the polarized targeting of Kv3.1 channels. PMID: 22105078
8. These results have demonstrated that N-glycans of the Kv3.1 glycoprotein enhance outward ionic current kinetics, and neuronal migration. PMID: 21541302
9. study to elucidate the relative distribution of Kv3.1b and Kv3.3 in specific compartments of the parallel fibers in the cerebellar cortex PMID: 20857303
10. A previously unknown interaction between the KV4 channel and Kv channel interacting protein (KChIP)3 in Muller cells could exert a physiological role in the onset of diabetic retinopathy. PMID: 21147063
11. Net amounts of Kv3.1b protein can change on a time scale of minutes in response to stimulus-driven synaptic activity, permitting auditory neurons to actively adapt their complement of ion channels to changes in the acoustic environment. PMID: 20219640
12. Kv3-like currents may be important for maintaining spike width and calcium influx within acceptable limits during repetitive firing. PMID: 15240761
13. Synaptic inputs evoked by stimulation of a region lacking Kv3.1b-IR neurons were not affected, correlating the presence of Kv3.1b in the tractus solitarius with the pharmacological effects. [Kv3.1b] PMID: 15528247
14. Both fast-firing and burst-firing parvalbumin+ interneurons in the basolateral amygdala express the Kv3.1b subunit. PMID: 16413129
15. the Kv3.1b channel is regulated by both conventional and novel PKC isozymes, and novel PKC-delta contributes specifically to the maintenance of basal phosphorylation in auditory neurons PMID: 16595659
16. The axon-dendrite targeting of Kv3.1 Shaw channel is controlled by a conditional interaction of a C-terminal axonal targeting motif with the N-terminal T1 domain and adaptor protein ankyrin G. PMID: 18094255
17. Suggest that fluoxetine acts on Kv3.1 currents as an open-channel blocker. PMID: 18187934
18. The results suggest that an altered expression of Kv3 channels affects the functional properties of FS neurons, and may contribute to the deficits in inhibition observed in the sensory-deprived cortex. PMID: 18708127
19. Report effect of psoralen on the cloned Kv3.1 currents. PMID: 19387585

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KEGG: rno:25327

STRING: 10116.ENSRNOP00000015260

UniGene: Rn.33095