Recombinant Rat Synaptotagmin-5(Syt5)

Code CSB-CF023041RA
Size Pls inquire other sizes
Source in vitro E.coli expression system
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Product Details

Target Names Syt5
Uniprot No. P47861
Alternative Names Syt5; Synaptotagmin-5; Synaptotagmin IX; Synaptotagmin V; SytV
Species Rattus norvegicus (Rat)
Expression Region 1-386
Protein Length full length protein
Tag Info The following tags are available.
N-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface.
Gene References into Functions
  1. Syt V is a dense-core vesicle-specific Syt isoform that controls a specific type of Ca2+-regulated secretion PMID: 12006594
  2. Syt IX is involved in regulating transport from the endocytic recycling compartment to the cell surface-( Synaptotagmin IX (Syt IX) PMID: 12966166
  3. Syt V and Syt IX are directly involved in the Ca2+ -dependent stimulation of exocytosis [Synaptotagmin IX] PMID: 15190121
  4. We show that targeting of Syt IX to the ERC involves constitutive trafficking to the plasma membrane followed by internalization and transport to the ERC. PMID: 15784685
Subcellular Location Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane, Single-pass membrane protein, Recycling endosome membrane, Single-pass membrane protein
Protein Families Synaptotagmin family
Tissue Specificity Expressed in kidney, adipose tissue, lung and heart, as well as at higher levels in brain.
Database Links

KEGG: rno:54309

STRING: 10116.ENSRNOP00000024547

UniGene: Rn.11030

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