SPIRE1 Antibody

Code	CSB-PA022588GA01HU
Size	100μl
Price	Request a Quote or Start an on-line Chat
Trial Size	24T ELISA Kit Trial Size (Only USD$150/ kit) * The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now

Product Details
Customer Reviews and Q&A
Target Background

Product Details

Alternative Names

KIAA1135 antibody; MGC150621 antibody; MGC150622 antibody; Protein spire homolog 1 antibody; Spir 1 antibody; Spir-1 antibody; Spir1 antibody; SPIR1_HUMAN antibody; SPIRE 1 antibody; Spire homolog 1 antibody; spire1 antibody

Abbreviation

SPIRE1

Uniprot No.

Q08AE8

Species

Homo sapiens (Human)

Troubleshooting
and FAQs

ELISA kit FAQs

Storage

Store at 2-8°C. Please refer to protocol.

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Target Background

Function
(From Uniprot)

Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage.

Gene References into Functions

interferes with bacterial binding in Salmonella typhimurium host cell invasion PMID: 27627128
Data suggest formin homology domain (FH2) of Fmn2 binds actin at filament barbed end as weak capper and plays a role in displacing WASP homology domain 2 (WH2) domains of Spire-1 from actin; competitive binding of Fmn2 vs Spire-1 aids actin assembly. PMID: 26668326
The authors propose Spire1C isoform cooperates with INF2 to regulate actin assembly at endoplasmic reticulum-mitochondrial contacts. PMID: 26305500
Spire recruits Fmn2 and facilitates its association with actin filaments barbed ends. PMID: 24586110
Spire-1 is specifically recruited at invadosomes and is part of a multi-molecular complex containing Src kinase, the formin mDia1 and actin. PMID: 24213528
The multifunctional character of the WH2 domains allows Spire to sequester four G-actin subunits binding cooperatively in a tight SA(4) complex and to nucleate, sever, and cap filaments at their barbed ends. PMID: 18042452

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Subcellular Location

Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.

Protein Families

Spire family

Database Links

HGNC: 30622

OMIM: 609216

KEGG: hsa:56907

STRING: 9606.ENSP00000387266

UniGene: Hs.515283

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