Code | CSB-E09936h |
Size | 96T,5×96T,10×96T |
Price | Request a Quote or Start an on-line Chat |
Trial Size |
24T ELISA Kit Trial Size (Only USD$150/ kit) * Sample kit cost can be deducted as a $30 credit for each 96-assay kit of the same analyte and brand you subsequently purchase in six months till depleted. Apply now |
The product CSB-E09936h is a sandwich ELISA kit developed to measure levels of human granulysin (GNLY) in the samples. This assay uses the sandwich enzyme immunoassay technique in combination with the enzyme-substrate chromogenic reaction to quantify the analyte in the sample. The color develops positively to the amount of GNLY in samples. The color intensity is measured at 450 nm via a microplate reader.
GNLY is a cytolytic and proinflammatory molecule expressed by activated human cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. NK cells release GNLY very early in immune responses, whereas CTLs release it after 3-5 days of activation. GNLY has cytolytic activity against microbes and tumors. Normal values of GNLY in the serum of healthy persons are 3.7 ±3.2 ng/ml. An increase in GNLY expression and levels in tissue and serum has been found in infections, autoimmune diseases, transplant rejection, and graft versus host reaction in patients with hematopoietic stem cell transplantation. Abnormal serum levels of GNLY in lymphomas with NK and cytotoxic phenotype have been shown to correlate with tumor progression.
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