Rat Insulin-like growth factor binding protein 5,IGFBP-5 ELISA kit

1. Insulin growth factor binding protein 5 (IGFBP-5), insulin growth factor (IGF-1) and transforming growth factor (TGF-beta1) in the type II alveolar epithelial cells (AECs) play a key role in lung injury caused by bleomycin and pioglitazone attenuates the lung injury/fibrosis by restoring IGFBP-5 and IGF-1 and decreasing TGF-beta1 expressions in the type II AECs. PMID: 28077319
2. Silencing IGFBP5 with small interfering RNA significantly reduced apoptosis and suppressed the expression of caspase3 in neonatal rat ventricular myocytes following treatment with methamphetamine. PMID: 25230843
3. IGFBP5 expression was up-regulated in the striatum of methamphetamine exposed male Sprague-Dawley rats. PMID: 25127757
4. IGFBP5 mediates high glucose-induced cardiac fibroblast activation PMID: 23417767
5. IGFs/IGFBPs may have important roles not only in fracture healing but also in nonunion formation. PMID: 21598309
6. Insulin-like growth factor-binding protein-5-induced laminin gamma1 transcription requires filamin A. PMID: 20167606
7. Downregulation of IGFBP-5 gene expression may cause pulmonary hypoplasia in the nitrofen-induced CDH model by interfering with retinoid signaling pathway. PMID: 19844724
8. Chronic exposure to high glucose leads to impaired mesangial cell migration in response to IGFBP-5 as a result of loss of laminin beta2 protein. PMID: 19864299
9. plays an important role in the development of the anterior pituitary gland PMID: 12006713
10. findings indicate that the modulation of rat ovarian insulin-like growth factor binding protein-4 and -5 is protein kinase C as well as protein kinase A dependent PMID: 12193414
11. IGFBP-3 and -5 proteins may have potential modulatory roles in type I fiber-dominated muscles, aging, and regrowth from atrophy. PMID: 12397024
12. Specific amino acid substitutions determine the differential contribution of the N- and C-terminal domains of insulin-like growth factor (IGF)-binding protein-5 in binding IGF-I PMID: 12626499
13. Overexpression of rat IGFBP-5 in transduced murine MC3T3 osteoblasts decreases osteoblastic function possibly by binding insulin-like growth factors in the bone microenvironment. PMID: 15589207
14. IGF-I uses different and only partially overlapping intracellular signaling pathways for regulation of IGFBP-3 and -5 with opposing biological functions might be important for modulation of IGF bioactivity in cellular microenvironment. PMID: 15845624
15. Although IGFBP-5 overexpression did not have an IGF-independent effect on RCJ cell differentiation, it promoted IGF-I-enhanced differentiation of these cells. PMID: 16204335
16. Inflammatory insults decrease muscle IGFBP-5 mRNA by a TNF-dependent glucocorticoid-independent mechanism. IGF-I appears to be a dominant positive regulator of IGFBP-5 gene expression in muscle under both normal and catabolic conditions. PMID: 16339387
17. Unique function for the laminin-9 complex in mediating IGFBP-5-induced migration. PMID: 16672690

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KEGG: rno:25285

STRING: 10116.ENSRNOP00000023530

UniGene: Rn.1593