SRSF10 Antibody

Datasheet

Code	CSB-PA525638LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA525638LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SRSF10 Polyclonal antibody

Uniprot No.

O75494

Target Names

SRSF10

Alternative Names

40 kDa SR repressor protein antibody; 40 kDa SR-repressor protein antibody; Anti TLS associated protein with SR repeats antibody; arginine/serine-rich 13A antibody; FUS interacting protein serine arginine rich 1 antibody; FUS interacting protein serine arginine rich 2 antibody; FUS interacting serine arginine rich protein 1 antibody; FUS-interacting serine-arginine-rich protein 1 antibody; FUSIP1 antibody; FUSIP2 antibody; NSSR antibody; OTTHUMP00000015774 antibody; Serine arginine repressor protein 40 kDa antibody; Serine/arginine-rich splicing factor 10 antibody; SFRS13 antibody; SFRS13A antibody; Splicing factor antibody; Splicing factor arginine serine rich 13 antibody; Splicing factor SRp38 antibody; SRp38 antibody; SRp40 antibody; SRrp40 antibody; SRS10_HUMAN antibody; Srsf10 antibody; TASR antibody; TASR1 antibody; TASR2 antibody; TLS associated protein TASR1 antibody; TLS associated protein TASR2 antibody; TLS associated protein with Ser Arg repeats antibody; TLS associated protein with SR repeats antibody; TLS associated serine arginine protein 1 antibody; TLS associated serine arginine protein 2 antibody; TLS associated serine arginine protein antibody; TLS associated SR protein antibody; TLS-associated protein with Ser-Arg repeats antibody; TLS-associated protein with SR repeats antibody; TLS-associated serine-arginine protein antibody; TLS-associated SR protein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Serine/arginine-rich splicing factor 10 protein (1-183AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SRSF10 Antibody (Product code: CSB-PA525638LA01HU) is Non-conjugated. For SRSF10 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA525638LB01HU	SRSF10 Antibody, HRP conjugated	ELISA
FITC	CSB-PA525638LC01HU	SRSF10 Antibody, FITC conjugated
Biotin	CSB-PA525638LD01HU	SRSF10 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator.

Gene References into Functions

DNA damage co-opts SRSF10 to control splicing decisions in transcripts encoding components involved in DNA repair, cell-cycle control, and apoptosis. PMID: 27851963
Results show that YTHDC1 promotes exon inclusion in targeted mRNAs through recruiting pre-mRNA splicing factor SRSF3 while blocking SRSF10 mRNA binding. PMID: 26876937
SRSF10 is a key regulator of BCLAF1 pre-mRNA splicing and the maintenance of oncogenic features in human colon cancer cells PMID: 25091051
In colorectal cancer, NSSR1 was highly expressed in the nucleus of tumor cells. PMID: 21984158
Splicing thermotolerance is acquired through maintenance of SRSF10 phosphorylation and that this is mediated at least in part by Hsp27. PMID: 21135127
Data show that SFRS13A expression was significantly associated with LDLR splicing efficiency in vivo. PMID: 20232416
found to be dephosphorylated specifically in mitotic cells; show that dephosphorylated SRp38 is required for the observed splicing repression PMID: 12419250
SRp38 plays a crucial role in cell survival under stress conditions by inhibiting the splicing machinery PMID: 14765198
SRp38 contains two arginine- and serine-rich domains (RS), one of which has a unique, second-step repression activity, while both function together as a splicing repression domain. PMID: 16135820

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Subcellular Location

Nucleus speckle. Cytoplasm.

Protein Families

Splicing factor SR family

Tissue Specificity

Widely expressed.

Database Links

HGNC: 16713

OMIM: 605221

KEGG: hsa:10772

STRING: 9606.ENSP00000420195

UniGene: Hs.3530

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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