FET3 Antibody

1. Presence of crowding agents does not affect Fet3p structural content but increases thermal resistance. The observations are compatible with ordering of a non-optimal substrate-binding site and restricted internal dynamics. PMID: 19932772
2. The D94 residue appears to activate a proton of the type 2 Cu(+)-bound water for participation in the transition state. PMID: 15835897
3. Substitution of Asp320 with asparagine essentially abolished the Fet3-dependent iron transport activity. All other mutants (D278Q, D279N, D312N and D315I) behaved essentially as the wild-type protein. PMID: 16032772
4. results are consistent with a (minimal) heterodimer model of the Fet3p.Ftr1p complex that supports the trafficking of iron from Fet3p to Ftr1p for iron permeation across the yeast plasma membrane PMID: 16522632
5. D283, E185, and D409 in Fet3p provide a Fe(II) binding site that actually favors ferric iron. PMID: 17042492
6. Structure-function analysis of the cuprous oxidase activity in Fet3p from Saccharomyces cerevisiae PMID: 17220296
7. We find that unfolding reactions of apo and different holo forms of Fet3p are irreversible reactions that depend on the scan rate and there is a metal-induced tradeoff between overall protein stability and metal coordination PMID: 19033465

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KEGG: sce:YMR058W

STRING: 4932.YMR058W