JIL-1 Antibody

1. our data indicate that the conserved H3S28 residue in metazoans has a role in supporting PRC2 catalysis. PMID: 26004180
2. results strongly suggest that the action of JIL-1 depends on which telomere domain, which chromosome and which promoter is embedded in the telomere chromatin. PMID: 24244743
3. JIL-1 regulated heterochromatin in the context of the chromocenter and fourth chromosome by creating a composite H3S10phK9me2 mark together with the Su(var)3-9 methyltransferase. PMID: 24429699
4. Enrichment of JIL-1 and the H3S10ph mark are predominantly associated with active genes in Drosophila. PMID: 24598257
5. The results suggest that JIL-1 is not a histone H3S28 kinase and that it is not involved in 14-3-3 recruitment in Drosophila. PMID: 23638096
6. epigenetic H3S10 phosphorylation mark itself functions as a causative regulator of chromatin structure independently of any structural contributions from the JIL-1 protein. PMID: 23723094
7. JIL-1 and Z4 (also known as Putzig), which are necessary for establishing a fine-tuned regulation of the transcription of the major component of Drosophila telomeres, the HeT-A retrotransposon, thus guaranteeing genome stability PMID: 23271984
8. JIL-1 and phosphoacetylated H3 histone are found at enhancers genome-wide prior to activation of transcription PMID: 22508764
9. JIL-1 loss-of-function alleles can act either as an enhancer or indirectly as a suppressor of w(m4) position-effect variegation depending on the precise levels of JIL-1 kinase activity. PMID: 22634714
10. Structural contributions from the JIL-1 protein are unlikely to play a role in counteracting heterochromatic spreading and gene silencing in position-effect variegation. PMID: 22247192
11. A balance between euchromatic (JIL-1) and heterochromatic [SU(var)2-5 and SU(var)3-9] factors regulates position-effect variegation in Drosophila. PMID: 21515582
12. JIL-1 participates in a complex histone modification network that characterises active, decondensed chromatin PMID: 21423663
13. Data show that in the absence of JIL-1 kinase activity, Su(var)3-7 gets redistributed and upregulated on the chromosome arms. PMID: 20457875
14. interaction with a developmentally regulated splice variant from the complex lola locus encoding multiple different zinc finger domain proteins PMID: 12538650
15. JIL-1 may exert such effects by a general regulation of chromatin structure affecting gene expression PMID: 14668387
16. The JIL-1 kinase regulates the structure of Drosophila polytene chromosomes. PMID: 15986206
17. JIL-1 kinase is required to maintain nuclear morphology and integrity of nurse cells during oogenesis; this function may be linked to molecular interactions with lamin Dm0. PMID: 16254246
18. Proper dosage compensation of eye pigment levels in males controlled by X-linked white alleles requires normal JIL-1 function. PMID: 16307450
19. JIL-1 functions in vivo in a pathway that includes Su(var)3-9, which is a major catalyst for dimethylation of the histone H3K9 residue, HP1 recruitment, and the formation of silenced heterochromatin. PMID: 16339185
20. JIL-1 and Chromator interact in an interband-specific complex that functions to establish or maintain polytene chromosome structure in Drosophila. PMID: 16723739
21. The gain of function allele is a suppressor strongly supporting a functional role for JIL-1 in maintaining euchromatic chromatin and counteracting heterochromatic spreading and gene silencing. PMID: 17435241
22. that a reduced level of histone H4 acetylated at Lys12 by ATAC attenuates histone H3 phosphorylation at Ser10 by JIL-1 owing to reduced binding of JIL-1 to hypoacetylated chromatin. PMID: 18796537
23. the COOH-terminal domain of the JIL-1 histone H3S10 kinase interacts with histone H3 and is required for correct targeting to chromatin PMID: 18819909

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KEGG: dme:Dmel_CG6297

STRING: 7227.FBpp0304953

UniGene: Dm.3098