JIL-1 Antibody

Code CSB-PA893223XA01DLU
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Product Details

Full Product Name Rabbit anti-Drosophila melanogaster (Fruit fly) JIL-1 Polyclonal antibody
Uniprot No. Q9V3I5
Target Names JIL-1
Alternative Names JIL-1 antibody; CG6297 antibody; Chromosomal serine/threonine-protein kinase JIL-1 antibody; EC antibody
Raised in Rabbit
Species Reactivity Drosophila melanogaster (Fruit fly)
Immunogen Recombinant Drosophila melanogaster (Fruit fly) JIL-1 protein
Immunogen Species Drosophila melanogaster (Fruit fly)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

(From Uniprot)
Phosphorylates 'Ser-10' of histone H3. May regulate gene expression by establishing or maintaining the structure of more open chromatin regions. Also required for normal polytene chromosome structure, for oogenesis and for viability throughout development. Regulates the structure of polytene chromosomes in salivary glands. May phosphorylate 'Ser-1' of histone H2A.
Gene References into Functions
  1. our data indicate that the conserved H3S28 residue in metazoans has a role in supporting PRC2 catalysis. PMID: 26004180
  2. results strongly suggest that the action of JIL-1 depends on which telomere domain, which chromosome and which promoter is embedded in the telomere chromatin. PMID: 24244743
  3. JIL-1 regulated heterochromatin in the context of the chromocenter and fourth chromosome by creating a composite H3S10phK9me2 mark together with the Su(var)3-9 methyltransferase. PMID: 24429699
  4. Enrichment of JIL-1 and the H3S10ph mark are predominantly associated with active genes in Drosophila. PMID: 24598257
  5. The results suggest that JIL-1 is not a histone H3S28 kinase and that it is not involved in 14-3-3 recruitment in Drosophila. PMID: 23638096
  6. epigenetic H3S10 phosphorylation mark itself functions as a causative regulator of chromatin structure independently of any structural contributions from the JIL-1 protein. PMID: 23723094
  7. JIL-1 and Z4 (also known as Putzig), which are necessary for establishing a fine-tuned regulation of the transcription of the major component of Drosophila telomeres, the HeT-A retrotransposon, thus guaranteeing genome stability PMID: 23271984
  8. JIL-1 and phosphoacetylated H3 histone are found at enhancers genome-wide prior to activation of transcription PMID: 22508764
  9. JIL-1 loss-of-function alleles can act either as an enhancer or indirectly as a suppressor of w(m4) position-effect variegation depending on the precise levels of JIL-1 kinase activity. PMID: 22634714
  10. Structural contributions from the JIL-1 protein are unlikely to play a role in counteracting heterochromatic spreading and gene silencing in position-effect variegation. PMID: 22247192
  11. A balance between euchromatic (JIL-1) and heterochromatic [SU(var)2-5 and SU(var)3-9] factors regulates position-effect variegation in Drosophila. PMID: 21515582
  12. JIL-1 participates in a complex histone modification network that characterises active, decondensed chromatin PMID: 21423663
  13. Data show that in the absence of JIL-1 kinase activity, Su(var)3-7 gets redistributed and upregulated on the chromosome arms. PMID: 20457875
  14. interaction with a developmentally regulated splice variant from the complex lola locus encoding multiple different zinc finger domain proteins PMID: 12538650
  15. JIL-1 may exert such effects by a general regulation of chromatin structure affecting gene expression PMID: 14668387
  16. The JIL-1 kinase regulates the structure of Drosophila polytene chromosomes. PMID: 15986206
  17. JIL-1 kinase is required to maintain nuclear morphology and integrity of nurse cells during oogenesis; this function may be linked to molecular interactions with lamin Dm0. PMID: 16254246
  18. Proper dosage compensation of eye pigment levels in males controlled by X-linked white alleles requires normal JIL-1 function. PMID: 16307450
  19. JIL-1 functions in vivo in a pathway that includes Su(var)3-9, which is a major catalyst for dimethylation of the histone H3K9 residue, HP1 recruitment, and the formation of silenced heterochromatin. PMID: 16339185
  20. JIL-1 and Chromator interact in an interband-specific complex that functions to establish or maintain polytene chromosome structure in Drosophila. PMID: 16723739
  21. The gain of function allele is a suppressor strongly supporting a functional role for JIL-1 in maintaining euchromatic chromatin and counteracting heterochromatic spreading and gene silencing. PMID: 17435241
  22. that a reduced level of histone H4 acetylated at Lys12 by ATAC attenuates histone H3 phosphorylation at Ser10 by JIL-1 owing to reduced binding of JIL-1 to hypoacetylated chromatin. PMID: 18796537
  23. the COOH-terminal domain of the JIL-1 histone H3S10 kinase interacts with histone H3 and is required for correct targeting to chromatin PMID: 18819909

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Subcellular Location Nucleus. Chromosome. Note=Associates with chromosomes throughout the cell cycle. Localizes to interband regions along the polytene chromosomes and is enriched almost two-fold on the male X chromosome compared to the autosome.
Protein Families Protein kinase superfamily, Ser/Thr protein kinase family
Database Links

KEGG: dme:Dmel_CG6297

STRING: 7227.FBpp0304953

UniGene: Dm.3098

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