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24T ELISA Kit Trial Size (Only USD$150/ kit)
The human progesterone-induced blocking factor (PIBF) Elisa kit is suitable for the quantitative measurement of human PIBF in serum, plasma, or tissue homogenates. This assay employs the competitive inhibition enzyme immunoassay technique and enzyme-substrate chromogenic reaction. The color develops oppositely to the amount of human PIBF in samples. The color development is stopped and the intensity of the color is measured. This kit displays many advantages, including sensitivity and specificity.
PIBF, encoded by the PIBF1 gene, plays an important in the support of healthy pregnancies and the maintenance of progesterone-dependent immunoregulation by the mother. It induces the decidual transformation of endometrial stromal cells, which is a prerequisite for successful implantation. Levels of PIBF are decreased in women at risk of premature pregnancy termination and preterm births. PIBF regulates key effector functions, including shifting cytokine synthesis and cytotoxic cell activity towards a more immunotolerant state. PIBF is regarded as a promising therapeutic marker in lymphocyte immunotherapy for the reduction of miscarriage risk.
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